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Autor:
Gerald Nabozny, Zofia Paw, Laura Beck, Daniel Kuzmich, Alison Kukulka, Richard M. Nelson, John R. Proudfoot, David S. Thomson, Younes Bekkali, Mario G. Cardozo, Cheng-Kon Shih, Patty Reilly, Rodney P. DeLeon, Kirrane Thomas M, Renee Zindell
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(18)
A new series of ligands for the glucocorticoid receptor (GR) is described. SAR development was guided by docking 3 into the GR active site and optimizing an unsubstituted phenyl ring for key interactions found in the steroid A-ring binding pocket. To