Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors

Autor: Jocelyn P. Wong, Jason R. Todd, Martina A. Finetti, Frank McCarthy, Malgorzata Broncel, Simon Vyse, Maciej T. Luczynski, Stephen Crosier, Karen A. Ryall, Kate Holmes, Leo S. Payne, Frances Daley, Patty Wai, Andrew Jenks, Barbara Tanos, Aik-Choon Tan, Rachael C. Natrajan, Daniel Williamson, Paul H. Huang

Publikováno v: Cell Reports, Vol 17, Iss 5, Pp 1265-1275 (2016)

Summary: Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here,

Externí odkaz: https://doaj.org/article/1ea3b596e8cc4e36bc647eff1eeb7332

3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer

Autor: Jyoti S. Choudhary, Lu Yu, Snezana Susnjar, Andrew Tutt, Patty Wai, Frances Daley, Natasa Medic Milijic, Rachael Natrajan, Daniela Kolarevic, Sophie Postel-Vinay, Barrie Peck, Ioanna Mavrommati, Hannah Cottom, Gareth Muirhead, Gillian Farnie, Gerard P. Quinn, Eleanor Knight, Rebecca Marlow, Richard Buus, Patrycja Gazinska, Simon S. McDade, Sunil Pancholi, Lesley-Ann Martin, Philip A. Bland, Naomi Guppy, Maggie C.U. Cheang, Sarah Maguire, Fredrik Wallberg, Amy Gibson, Paul H. Huang, Daniela Novo, Keith Brennan, Divya Kriplani, Farzana Noor, Giulia Falgari, Erle Holgersen, Eamonn Morrison, Syed Haider, Holly E. Barker, Kalnisha Naidoo, Ioannis Roxanis, Lukas Krasny

Publikováno v: Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res

Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e592d50d40abfd2812812de9e1d658c
https://doi.org/10.1158/0008-5472.CAN-20-1822

Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures

Autor: Andri Leonidou, Patty Wai, Gillian Farnie, Saira Khalique, Philip A. Bland, Barrie Peck, Frances Daley, Rachael Natrajan, Eamonn Morrison

Publikováno v: Morrison, E, Wai, P, Leonidou, A, Bland, P, Khalique, S, Farnie, G, Daley, F, Peck, B & Natrajan, R 2016, ' Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures ', Journal of Visualized Experiments, vol. 2016, no. 118, e54738, pp. 1-8 . https://doi.org/10.3791/54738
Journal of Visualized Experiments : JoVE

The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets. It is becoming apparent that more complex models o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15da75b20fdcaf91449042761f32eeea
https://doi.org/10.3791/54738

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

Autor: Adriana C. Flora, Richard Marais, Dominique Stoppa-Lyonnet, Roger A'Hern, Alan Mackay, Iwanka Kozarewa, Vidya Pawar, Alan Ashworth, Christopher J. Lord, Odette Mariani, Petra van der Groep, Marc-Henri Stern, Andrew R. Green, Simon J. Furney, William D. Foulkes, Rachael Natrajan, Jason S. Carroll, Simon S. McDade, Elodie Manié, Patty Wai, Maryou B. Lambros, Charles Swanton, Paul J. van Diest, Anne Vincent-Salomon, Britta Weigelt, Jorge S. Reis-Filho, Ian O. Ellis, Tatiana Popova, Samra Turajlic, Anita Grigoriadis, Olivier Delattre, Daniel Nava Rodruigues, Paul M. Wilkerson

Publikováno v: The Journal of Pathology. 227:29-41

BRCA1 encodes a tumour suppressor protein that plays pivotal roles in homologous recombination (HR) DNA repair, cell-cycle checkpoints, and transcriptional regulation. BRCA1 germline mutations confer a high risk of early-onset breast and ovarian canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07e96fc5e08782ed971813ab9d101a1
https://doi.org/10.1002/path.4003

Modelling the tumour microenvironment and employing functional genomics identifies CREBBP as a novel tumour suppressor in triple negative breast cancers

Autor: Barrie Peck, Patty Wai, Sarah Maguire, E. Morrison, Rachael Natrajan

Publikováno v: European Journal of Cancer. 61:S73-S74

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4488cc8555465286e60ea151ef67d250
https://doi.org/10.1016/s0959-8049(16)61256-x