PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia

Autor: Herriott, Ashleigh, Tudhope, Susan J., Junge, Gesa, Rodrigues, Natalie, Patterson, Miranda J., Woodhouse, Laura, Lunec, John, Hunter, Jill E., Mulligan, Evan A., Cole, Michael, Allinson, Lisa M., Wallis, Jonathan P., Marshall, Scott, Wang, Evelyn, Curtin, Nicola J., Willmore, Elaine

Publikováno v: Oncotarget

In chronic lymphocytic leukemia (CLL), mutation and loss of p53 and ATM abrogate DNA damage signalling and predict poorer response and shorter survival. We hypothesised that poly (ADP-ribose) polymerase (PARP) activity, which is crucial for repair of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c64c4c3fa48cce345d62a207a6b0cb4
http://europepmc.org/articles/PMC4791280

Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency

Autor: Kos, Iaroslava, Patterson, Miranda J, Znaidi, Sadri, Kaloriti, Despoina, da Silva Dantas, Alessandra, Herrero-de-Dios, Carmen M, D'Enfert, Christophe, Brown, Alistair J P, Quinn, Janet

Publikováno v: mBio
mBio, American Society for Microbiology, 2016, 7 (2), pp.e00331-16. ⟨10.1128/mBio.00331-16⟩
mBio, Vol 7, Iss 2 (2016)
mBio, 2016, 7 (2), pp.e00331-16. ⟨10.1128/mBio.00331-16⟩
mBio, Vol 7, Iss 2, p e00331-16 (2016)

Following phagocytosis, microbes are exposed to an array of antimicrobial weapons that include reactive oxygen species (ROS) and cationic fluxes. This is significant as combinations of oxidative and cationic stresses are much more potent than the cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b3e10f3c9d17b5391e8fea3fb7db274b
https://hal-pasteur.archives-ouvertes.fr/pasteur-01517857

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