Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Patsy Tomlinson"'
Autor:
Albert Kwok, Ilona Zvetkova, Sam Virtue, Ineke Luijten, Isabel Huang-Doran, Patsy Tomlinson, David A. Bulger, James West, Steven Murfitt, Julian Griffin, Rafeah Alam, Daniel Hart, Rachel Knox, Peter Voshol, Antonio Vidal-Puig, Jørgen Jensen, Stephen O'Rahilly, Robert K. Semple
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101020- (2020)
Objective: Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), surprisingly without fatty liver o
Externí odkaz:
https://doaj.org/article/82f6d95279d840059ee0a0ab5c79af2b
Autor:
Daniel Hart, Steven A. Murfitt, Albert Kwok, Patsy Tomlinson, David A Bulger, Antonio Vidal-Puig, Peter J. Voshol, Ineke Luijten, James A. West, Robert K. Semple, Julian L. Griffin, Jørgen Arendt Jensen, Samuel Virtue, Rachel G. Knox, Stephen O'Rahilly, Ilona Zvetkova, Rafeah Alam, Isabel Huang-Doran
Publikováno v:
Molecular Metabolism, Vol 40, Iss, Pp 101020-(2020)
Molecular Metabolism
Kwok, A, Zvetkova, I, Virtue, S, Luijten, I, Huang-doran, I, Tomlinson, P, Bulger, D A, West, J, Murfitt, S, Griffin, J, Alam, R, Hart, D, Knox, R, Voshol, P, Vidal-puig, A, Jensen, J, O’rahilly, S & Semple, R K 2020, ' Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidemia by increased energy expenditure ', Molecular Metabolism, pp. 101020 . https://doi.org/10.1016/j.molmet.2020.101020
Molecular Metabolism
Kwok, A, Zvetkova, I, Virtue, S, Luijten, I, Huang-doran, I, Tomlinson, P, Bulger, D A, West, J, Murfitt, S, Griffin, J, Alam, R, Hart, D, Knox, R, Voshol, P, Vidal-puig, A, Jensen, J, O’rahilly, S & Semple, R K 2020, ' Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidemia by increased energy expenditure ', Molecular Metabolism, pp. 101020 . https://doi.org/10.1016/j.molmet.2020.101020
Objective Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), surprisingly without fatty liver or
Autor:
Isabel Huang-Doran, Peter J. Voshol, Albert Kwok, Ilona Zvetkova, David A Bulger, Sam Virtue, Amanda N. Sferruzzi-Perri, Rachel G. Knox, Antonio Vidal-Puig, Daniel Hart, Jørgen Arendt Jensen, Patsy Tomlinson, Robert K. Semple, Stephen Franks, Stephen O'Rahilly
SummaryHeterodimeric class IA phosphatidylinositol-3-kinases (PI3K) transduce signals from many receptor tyrosine kinases including the insulin receptor. PI3K recruitment to phosphotyrosines is mediated by Pik3r1 gene products including the most inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984ceecac4ca71c5f36fb4416afda520
https://doi.org/10.1101/224485
https://doi.org/10.1101/224485