Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Patsy Hinson"'
Autor:
Mark D Stewart, Diana Merino Vega, Rebecca C Arend, Jonathan F Baden, Olena Barbash, Nike Beaubier, Grace Collins, Tim French, Negar Ghahramani, Patsy Hinson, Petar Jelinic, Matthew J Marton, Kimberly McGregor, Jerod Parsons, Lakshman Ramamurthy, Mark Sausen, Ethan S Sokol, Albrecht Stenzinger, Hillary Stires, Kirsten M Timms, Diana Turco, Iris Wang, J Andrew Williams, Elaine Wong-Ho, Jeff Allen
Publikováno v:
The Oncologist. 27:167-174
Background Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involv
Autor:
Panagiotis A Konstantinopoulos, Antonio Gonzalez-Martin, Felipe Melo Cruz, Michael Friedlander, Rosalind Glasspool, Domenica Lorusso, Christian Marth, Bradley J Monk, Jae-Weon Kim, Patsy Hinson, Olga Ajipa, Vincent Pretre, Yu Han, Ursula A Matulonis
Publikováno v:
Future oncology (London, England).
Patients with platinum-resistant or -refractory high-grade serous ovarian cancer (HGSOC) have a poor prognosis, and their management represents a substantial unmet medical need. Preclinical data and results from a phase Ib trial demonstrated the effi