Výsledky vyhledávání - "Patsy G Oliver"

Akademický článek

A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.

Autor: Praveen K Vayalil, Joo-Yeun Oh, Fen Zhou, Anne R Diers, M Ryan Smith, Hafez Golzarian, Patsy G Oliver, Robin A J Smith, Michael P Murphy, Sadanandan E Velu, Aimee Landar

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120460 (2015)

Despite advances in screening and treatment over the past several years, breast cancer remains a leading cause of cancer-related death among women in the United States. A major goal in breast cancer treatment is to develop safe and clinically useful

Externí odkaz: https://doaj.org/article/12e59c8641af42228ba786a8797bd8f0

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Akademický článek

RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long‐term survival and reveals a role for ANGPTL4

Autor: Marie K. Kirby, Ryne C. Ramaker, Jason Gertz, Nicholas S. Davis, Bobbi E. Johnston, Patsy G. Oliver, Katherine C. Sexton, Edward W. Greeno, John D. Christein, Martin J. Heslin, James A. Posey, William E. Grizzle, Selwyn M. Vickers, Donald J. Buchsbaum, Sara J. Cooper, Richard M. Myers

Publikováno v: Molecular Oncology, Vol 10, Iss 8, Pp 1169-1182 (2016)

Background Pancreatic adenocarcinoma patients have low survival rates due to late‐stage diagnosis and high rates of cancer recurrence even after surgical resection. It is important to understand the molecular characteristics associated with surviva

Externí odkaz: https://doaj.org/article/18b28309935b4450822c1557f59a1f5b

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Akademický článek

Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Autor: M. Ryan Smith, Praveen K. Vayalil, Fen Zhou, Gloria A. Benavides, Reena R. Beggs, Hafez Golzarian, Bhavitavya Nijampatnam, Patsy G. Oliver, Robin A.J. Smith, Michael P. Murphy, Sadanandan E. Velu, Aimee Landar

Publikováno v: Redox Biology, Vol 8, Iss C, Pp 136-148 (2016)

Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron transport chain and am

Externí odkaz: https://doaj.org/article/28598c4d4dc14203b4dba36a2bf4aa84

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Data from Treatment of Human Colon Cancer Xenografts with TRA-8 Anti-death Receptor 5 Antibody Alone or in Combination with CPT-11

Autor: Donald J. Buchsbaum, Wenquan Wang, Tong Zhou, Li Nan, Hyunki Kim, Kurt R. Zinn, Albert F. LoBuglio, Patsy G. Oliver

Purpose: This study was designed to evaluate the in vitro cytotoxicity and in vivo efficacy of TRA-8, a mouse monoclonal antibody that binds to the DR5 death receptor for tumor necrosis factor–related apoptosis-inducing ligand (also called Apo2L),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc55ac0a366bc4004b8e8ba1dd716e0
https://doi.org/10.1158/1078-0432.c.6518289.v1

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STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer

Autor: James Turkson, Peibin Yue, Katherine E. Varley, Joy M. McDaniel, Stephanie L. Parker, Donald J. Buchsbaum, Bryan E. Welm, Katrin P. Guillen, Richard M. Myers, Patsy G. Oliver, Megan E. Conway, James M. Graham

Publikováno v: Cancer Res

Breast cancers are divided into subtypes with different prognoses and treatment responses based on global differences in gene expression. Luminal breast cancer gene expression and proliferation are driven by estrogen receptor alpha, and targeting thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7582232f9872e9152d2134df7ba0f7be
https://doi.org/10.1158/0008-5472.can-20-1379

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PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression

Autor: Donald J. Buchsbaum, Sumit Agarwal, Dafydd G. Thomas, Nirzari Gupta, Patsy G. Oliver, Isam-Eldin Eltoum, Hyung-Gyoon Kim, Sai Akshaya Hodigere Balasubramanya, Upender Manne, Kevin Hale, Sooryanarayana Varambally, Balabhadrapatruni V. S. K. Chakravarthi

Publikováno v: Translational Oncology
Translational Oncology, Vol 13, Iss 7, Pp 100776-(2020)

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor prognosis. There is an urgent need to identify new therapeutic targets and also understand the mechanism of PDAC progression that leads to aggressiveness of the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d4241b8da10e165d21b54554a0b4f5
http://europepmc.org/articles/PMC7229293

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FTY720 enhances the anti-tumor activity of carboplatin and tamoxifen in a patient-derived xenograft model of ovarian cancer

Autor: Rebecca C. Arend, Karina J. Yoon, Ronald D. Alvarez, Rebecca B. Vance, Patsy G. Oliver, Samuel C. Fehling, Charles N. Landen, Ashwini A. Katre, Kelly M. Kreitzburg, Robert C.A.M. van Waardenburg, Tracy L. Gamblin

Publikováno v: Cancer Letters. 436:75-86

Ovarian cancer is the fifth leading cause of cancer-related deaths among women in the United States. Although most patients respond to frontline therapy, virtually all patients relapse with chemoresistant disease. This study addresses the hypothesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69386e1c32b80a8a31951167718d25af
https://doi.org/10.1016/j.canlet.2018.08.015

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