The DNA hypermethylation phenotype of colorectal cancer liver metastases resembles that of the primary colorectal cancers

Autor: Stephany Orjuela, Mirco Menigatti, Peter Schraml, Patryk Kambakamba, Mark D. Robinson, Giancarlo Marra

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)

Abstract Background Identifying molecular differences between primary and metastatic colorectal cancers—now possible with the aid of omics technologies—can improve our understanding of the biological mechanisms of cancer progression and facilitat

Externí odkaz: https://doaj.org/article/1250ee2714d74cb79272aa6a49e22371

The evolution of surgery for colorectal liver metastases: A persistent challenge to improve survival

Autor: Emir Hoti, Felix Braun, Michael Linecker, Sinead Cremen, Thomas E. Becker, Patryk Kambakamba

Publikováno v: Surgery. 170:1732-1740

Only a few decades ago, the opinion that colorectal liver metastases were a palliative diagnosis changed. In fact, previously, the prevailing view was strongly resistant against resecting colorectal liver metastases. Constant technical improvement of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750c333f56b77dc76a5e444cd4c20736
https://doi.org/10.1016/j.surg.2021.06.033

Outruling cholangiocarcinoma in patients with primary sclerosing cholangitis wait-listed for liver transplantation: A report on the Irish national experience

Autor: William P. Duggan, Conor Brosnan, Natasha Christodoulides, Niamh Nolan, Patryk Kambakamba, Tom K. Gallagher

Publikováno v: The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

The presence of diffuse biliary stricturing in Primary Sclerosing Cholangitis (PSC) makes the diagnosis of early Cholangiocarcinoma (CCA) in this context difficult. A finding of incidental CCA on liver explant is associated with poor oncological outc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ea83d341a2c2bd85e7ca70b0dc00b
https://pubmed.ncbi.nlm.nih.gov/35680491

First Long-term Oncologic Results of the ALPPS Procedure in a Large Cohort of Patients With Colorectal Liver Metastases

Autor: Carlos Castro-Benitez, Roberto Brusadin, Jun Li, Martin Teutsch, Luca Aldrighetti, Patryk Kambakamba, Jan Bednarsch, Arianeb Mehrabi, Mauro E Tun Abraham, Marcus N. Scherer, François-René Pruvot, Roberto Hernandez-Alejandro, Eduardo Fernandes, Christoph Kuemmerli, Emir Hoti, Onur Elvan Kirimker, Federico Tomassini, Tim Reese, Francesca Ratti, Pim B. Olthof, Stéphanie Truant, Ivan Capobianco, Roberto Troisi, Mohammad-Hossein Fard-Aghaie, Henrik Petrowsky, Victor Lopez-Lopez, Philipp Kron, Pierre-Alain Clavien, Hans J. Schlitt, Ricardo Robles-Campos, Omid Ghamarnejad, Silvio Nadalin, Thomas M. van Gulik, René Adam, Deniz Balci, Marcel Autran C. Machado, Peter Lodge, Ralph Fritsch, Dimitri A. Raptis, Sergey Voskanyan, Georg Lurje, Karl J. Oldhafer, Massimo Malagó, Michael Linecker, Eduardo de Santibañes, Victoria Ardiles

Publikováno v: Annals of surgery. 272(5)

Objectives: To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients with colorectal liver metastases (CRLM) undergoing ALPPS. Background: ALPPS is a two-stage hepatectomy variant that increases resect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b609d6766fc3183383670cdf74f254bf
https://pubmed.ncbi.nlm.nih.gov/32833765

Exercise Improves Outcomes of Surgery on Fatty Liver in Mice: A Novel Effect Mediated by the AMPK Pathway

Autor: Christoph Tschuor, Lukas Frick, Yinghua Tian, Pierre-Alain Clavien, Michael Linecker, Magda Langiewicz, Bostjan Humar, Perparim Limani, Nicolas Calo, Rolf Graf, Marcel André Schneider, Philipp Kron, Patryk Kambakamba, Jean-François Dufour, Udo Ungethüm, Michelangelo Foti, Ekaterina Kachaylo

Publikováno v: Linecker, Michael; Frick, Lukas; Kron, Philipp; Limani, Perparim; Kambakamba, Patryk; Tschuor, Christoph; Langiewicz, Magda; Kachaylo, Ekaterina; Tian, Yinghua; Schneider, Marcel A; Ungethüm, Udo; Calo, Nicolas; Foti, Michelangelo; Dufour, Jean-François; Graf, Rolf; Humar, Bostjan; Clavien, Pierre-Alain (2020). Exercise Improves Outcomes of Surgery on Fatty Liver in Mice: A Novel Effect Mediated by the AMPK Pathway. Annals of surgery, 271(2), pp. 347-355. Lippincott Williams & Wilkins 10.1097/SLA.0000000000002904
Annals of Surgery (2018)

OBJECTIVE To investigate whether exercise improves outcomes of surgery on fatty liver, and whether pharmacological approaches can substitute exercising programs. SUMMARY OF BACKGROUND DATA Steatosis is the hepatic manifestation of the metabolic syndr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ca482dc1071d3dc0e447b6ac209dcf
https://boris.unibe.ch/120167/1/00000658-900000000-95422.pdf