Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Patrycja K. Thompson"'
Autor:
Patrycja K. Thompson, Edward L. Y. Chen, Renée F. de Pooter, Catherine Frelin, Walter K. Vogel, Christina R. Lee, Thomas Venables, Divya K. Shah, Norman N. Iscove, Mark Leid, Michele K. Anderson, Juan Carlos Zúñiga-Pflücker
Publikováno v:
J Immunol
The zinc-finger transcription factor GATA-3 plays a crucial role during early T cell development and also dictates later T cell differentiation outcomes. However, its role and collaboration with the Notch signaling pathway in the induction of T linea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6731af602c9d0cd8173503c1d6e959
https://doi.org/10.4049/jimmunol.2100366
https://doi.org/10.4049/jimmunol.2100366
Publikováno v:
Nature immunology
T cell specification and commitment require Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is known, it is still unclear whether the onset of T cell priming can occur in a prethymic niche and wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f841e30def58446ede8930dad87ed6a9
https://doi.org/10.1038/s41590-019-0518-7
https://doi.org/10.1038/s41590-019-0518-7
Autor:
Juan Carlos Zúñiga-Pflücker, David L. Wiest, Christina R. Lee, Patrycja K. Thompson, Michele K. Anderson, Edward L. Y. Chen
Publikováno v:
Cell reports
SUMMARY γδ T cells form an integral arm of the immune system and are critical during protective and destructive immunity. However, how γδ T cells are functionally programmed in vivo remains unclear. Here, we employ RBPJ-inducible and KN6-transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8ff56a1cee92121e3aab0541c2bedc
https://doi.org/10.1016/j.celrep.2021.109227
https://doi.org/10.1016/j.celrep.2021.109227
Autor:
Qiang Shen, Patrycja K. Thompson, Juan Carlos Zúñiga-Pflücker, Bernard Martin, Ramtin Rahbar, Hal K. Berman, Pamela S. Ohashi, Kiichi Murakami, Brenda Cohen, Sara Lamorte, Weiyue Zheng, Michael Reedijk
Publikováno v:
Cancer Discovery. 7:1320-1335
Notch activation, which is associated with basal-like breast cancer (BLBC), normally directs tissue patterning, suggesting that it may shape the tumor microenvironment. Here, we show that Notch in tumor cells regulates the expression of two powerful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e610046036e31b172f04b58799c9c3
https://doi.org/10.1158/2159-8290.cd-17-0037
https://doi.org/10.1158/2159-8290.cd-17-0037
Publikováno v:
Seminars in immunology. 23(5)
The thymus is seeded by bone marrow-derived progenitors, which undergo a series of differentiation and proliferation events in order to generate functional T lymphocytes. The Notch signaling pathway, together with multiple transcription factors, act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2353771072a2587af2649f98d7e07cf8
https://pubmed.ncbi.nlm.nih.gov/21981947
https://pubmed.ncbi.nlm.nih.gov/21981947