Výsledky vyhledávání - "Patrycja J. Lech"

Akademický článek

Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies.

Autor: Patrycja J Lech, Gregory J Tobin, Ruth Bushnell, Emily Gutschenritter, Linh D Pham, Rebecca Nace, Els Verhoeyen, François-Loïc Cosset, Claude P Muller, Stephen J Russell, Peter L Nara

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e52306 (2013)

The measles virus (MV) is serologically monotypic. Life-long immunity is conferred by a single attack of measles or following vaccination with the MV vaccine. This is contrary to viruses such as influenza, which readily develop resistance to the immu

Externí odkaz: https://doaj.org/article/eba3e96446de4ab3bea86ce87ae92051

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Development and validation of IMMUNO-COV™: a high-throughput clinical assay for detecting antibodies that neutralize SARS-CoV-2

Publikováno v: mSphere
bioRxiv

Neutralizing antibodies are key determinants of protection from future infection, yet well-validated high-throughput assays for measuring titers of SARS-CoV-2-neutralizing antibodies are not generally available. Here, we describe the development and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68833cf8dc4c45f4629b6f7098f4f52f
https://doi.org/10.1101/2020.05.26.117549

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Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS)

Autor: Hristina R. Zhekova, Stephen J. Russell, Toshie Sakuma, Susanna C. Concilio, Mirna Damergi, Igor Zdravkovic, Patrycja J. Lech, Ryan Johnson, Kah-Whye Peng, Sergei Y. Noskov, Lukkana Suksanpaisan

Publikováno v: J Chem Inf Model

The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c1e83293268488795b25915e0b0104
https://europepmc.org/articles/PMC7249729/

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Use of attenuated paramyxoviruses for cancer therapy

Autor: Stephen J. Russell, Patrycja J. Lech

Publikováno v: Expert Review of Vaccines. 9:1275-1302

Paramyxoviruses, measles virus (MV), mumps virus (MuV) and Newcastle disease virus (NDV), are well known for causing measles and mumps in humans and Newcastle disease in birds. These viruses have been tamed (attenuated) and successfully used as vacci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e47db6a599fae17006ba98bbfaca1c
https://doi.org/10.1586/erv.10.124

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Antibody neutralization of retargeted measles viruses

Autor: Patrycja J. Lech, Peter L. Nara, Gregory J. Tobin, Roland Pappoe, Takafumi Nakamura, Stephen J. Russell

The measles virus (MV) vaccine lineage is a promising oncolytic but prior exposure to the measles vaccine or wild-type MV strains limits treatment utility due to the presence of anti-measles antibodies. MV entry can be redirected by displaying a poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79357ba68b84a4b9355c89e049235e87
https://europepmc.org/articles/PMC4123749/

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Epitope Dampening Monotypic Measles Virus Hemagglutinin Glycoprotein Results in Resistance to Cocktail of Monoclonal Antibodies

Autor: Gregory J. Tobin, Peter L. Nara, Patrycja J. Lech, Stephen J. Russell, François-Loïc Cosset, Ruth V. Bushnell, Linh Pham, Rebecca A. Nace, Claude P. Muller, Emily Gutschenritter, Els Verhoeyen

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (1), pp.e52306. ⟨10.1371/journal.pone.0052306⟩
PLoS ONE, 2013, 8 (1), pp.e52306. ⟨10.1371/journal.pone.0052306⟩
PLoS ONE, Vol 8, Iss 1, p e52306 (2013)

International audience; The measles virus (MV) is serologically monotypic. Life-long immunity is conferred by a single attack of measles or following vaccination with the MV vaccine. This is contrary to viruses such as influenza, which readily develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99afc8d26b25b42dd2fb37ee401fee27
http://europepmc.org/articles/PMC3536790

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416. Enhanced Oncolytic Effect of Tumor Necrosis Factor Alpha Armed Engineered Oncolytic Measles Virus Therapy for Ovarian Carcinoma Cell Line

Autor: Patrycja J. Lech, Ahmed Majeed Al-Shammari, Stephen J. Russell

Publikováno v: Molecular Therapy. 24:S165

Introduction. Tumor necrosis factor alpha (TNFa) has been recognized having anticancer properties, and proposed as a cancer treatment early in the 1980s, But its toxicity lead to limited use. Replication competent oncolytic viruses such as live atten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02222e3b379b71cae5468162cecf9b38
https://doi.org/10.1016/s1525-0016(16)33225-7

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Characterization of the Sodium Iodide Symporter Binding Sites

Autor: Igor Zdravkovic, Patrycja J. Lech, Sergei Y. Noskov, Stephen J. Russell

Publikováno v: Biophysical Journal. (2):308a-309a

Sodium iodide symporter (NIS) is a membrane protein responsible for accumulation of iodide (I-) in the thyroid and other organs. This is accomplished through active transports in which the sodium (Na+) gradient provides the driving force. In our appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066fb475657f010b5e1863245f3ea310

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