Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Patrycja Gralewska"'
1
Akademický článek
Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer
Autor: Patrycja Gralewska, Arkadiusz Gajek, Agnieszka Marczak, Aneta Rogalska
Publikováno v: Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-16 (2020)
Abstract Ovarian cancer is one of the most lethal gynecologic malignancies reported throughout the world. The initial, standard-of-care, adjuvant chemotherapy in epithelial ovarian cancer is usually a platinum drug, such as cisplatin or carboplatin,
Externí odkaz: https://doaj.org/article/89b35b142559423aabf3d1ac093f5154
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2
Akademický článek
The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer Cells
Autor: Patrycja Gralewska, Arkadiusz Gajek, Dorota Rybaczek, Agnieszka Marczak, Aneta Rogalska
Publikováno v: Cells, Vol 11, Iss 12, p 1889 (2022)
Olaparib is a poly (ADP-ribose) polymerase inhibitor (PARPi) that inhibits PARP1/2, leading to replication-induced DNA damage that requires homologous recombination repair. Olaparib is often insufficient to treat BRCA-mutated (BRCAMUT) and BRCA wild-
Externí odkaz: https://doaj.org/article/636c2ed57b2e4e9f866ae2502ea22d39
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3
Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer
Autor: Agnieszka Marczak, Arkadiusz Gajek, Patrycja Gralewska, Aneta Rogalska
Publikováno v: Cancers
Cancers, Vol 13, Iss 2690, p 2690 (2021)
Simple Summary Ovarian cancer is the leading cause of death from gynecological malignancies. Recent studies have focused on ovarian cancer-associated microRNAs that play strong regulatory roles in various cellular processes. While miRNAs have been sh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14611deef6659dfc41460cd3fd9ce521
https://pubmed.ncbi.nlm.nih.gov/34072593
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5
A potential role of calpains in sulfonylureas (SUs) -mediated death of human pancreatic cancer cells (1.2B4)
Autor: Patrycja Gralewska, Izabela Szymczak-Pajor, Jacek Kasznicki, Krzysztof Fleszar, Agnieszka Śliwińska
Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 73
Sulfonylureas (SUs) are suggested to accelerate the pancreatic β-cells mass loss via apoptosis. However, little is known whether calpains mediate this process. The aim of the present study is to evaluate the involvement of calpains in SUs-induced de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbb6422828eda280c97c0dbf68f28f0
https://pubmed.ncbi.nlm.nih.gov/33652124
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6
PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness
Autor: Jerzy Ostrowski, Patrycja Gralewska, Agnieszka Marczak, Michal Mikula, Aneta Rogalska, Agnieszka Śliwińska, Arkadiusz Gajek
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9715, p 9715 (2020)
Volume 21
Issue 24
Poly (ADP-ribose) polymerase inhibitor (PARPi, olaparib) impairs the repair of DNA single-strand breaks (SSBs), resulting in double-strand breaks (DSBs) that cannot be repaired efficiently in homologous recombination repair (HRR)-deficient cancers su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e929713c798244f5c6397eb92588ea82
https://pubmed.ncbi.nlm.nih.gov/33352723
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7
Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer
Autor: Agnieszka Marczak, Patrycja Gralewska, Arkadiusz Gajek, Aneta Rogalska
Publikováno v: Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-16 (2020)
Ovarian cancer is one of the most lethal gynecologic malignancies reported throughout the world. The initial, standard-of-care, adjuvant chemotherapy in epithelial ovarian cancer is usually a platinum drug, such as cisplatin or carboplatin, combined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006b5acbb78d33aa98c44884cb592e34
https://doi.org/10.1186/s13045-020-00874-6
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8
Metformin Affects Olaparib Sensitivity through Induction of Apoptosis in Epithelial Ovarian Cancer Cell Lines
Autor: Patrycja Gralewska, Aneta Rogalska, Arkadiusz Gajek, Agnieszka Marczak
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10557, p 10557 (2021)
This study examined the effect of combination treatment with the poly (ADP-ribose) polymerase inhibitor olaparib and metformin on homologous recombination (HR)-proficient epithelial ovarian cancer (EOC). Ovarian cancer cell lines (OV-90 and SKOV-3) w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59078c0db12a9e2977001d705ad2187
https://doi.org/10.3390/ijms221910557
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