Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Patrizia Stoitzner"'
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Autor:
Lucía López, Luciano Gastón Morosi, Federica La Terza, Pierre Bourdely, Giuseppe Rospo, Roberto Amadio, Giulia Maria Piperno, Valentina Russo, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Luigia Pace, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presenting cDC1 and the potential of DC-based therapies in
Externí odkaz:
https://doaj.org/article/f7c6a9ff87e544acbdd02715c577e12b
Autor:
Ian F Hermans, Christoph H Tripp, Florian Hornsteiner, Zlatko Trajanoski, Patrizia Stoitzner, Marc Schmitz, Natascha Hermann-Kleiter, Francesca Finotello, Janine Vierthaler, Helen Strandt, Antonia Resag, Zhe Fu, Markus Ausserhofer, Sophie Dieckmann, Markus Kanduth, Kathryn Farrand, Sarah Bregar, Niloofar Nemati, Athanasios Seretis, Sudhir Morla, David Mullins, Guido Wollmann, Franca Ronchese
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Tumor-targeted therapy causes impressive tumor regression, but the emergence of resistance limits long-term survival benefits in patients. Little information is available on the role of the myeloid cell network, especially dendritic cells
Externí odkaz:
https://doaj.org/article/8ba13b7814a54dc4b691708cf8293e28
Autor:
Tina Rauchenwald, Florian Handle, Catherine E. Connolly, Antonia Degen, Christof Seifarth, Martin Hermann, Christoph H. Tripp, Doris Wilflingseder, Susanne Lobenwein, Dragana Savic, Leo Pölzl, Evi M. Morandi, Dolores Wolfram, Ira-Ida Skvortsova, Patrizia Stoitzner, Johannes Haybaeck, Marko Konschake, Gerhard Pierer, Christian Ploner
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-20 (2023)
Abstract Background Chronic non-healing wounds pose a global health challenge. Under optimized conditions, skin wounds heal by the formation of scar tissue. However, deregulated cell activation leads to persistent inflammation and the formation of gr
Externí odkaz:
https://doaj.org/article/9014046b60234461bfe0de1e1d4671f7
Autor:
Sandra Grund‐Gröschke, Daniela Ortner, Antal B. Szenes‐Nagy, Nadja Zaborsky, Richard Weiss, Daniel Neureiter, Martin Wipplinger, Angela Risch, Peter Hammerl, Richard Greil, Maria Sibilia, Iris K. Gratz, Patrizia Stoitzner, Fritz Aberger
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 1930-1946 (2020)
Genetic activation of hedgehog/glioma‐associated oncogene homolog (HH/GLI) signaling causes basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an ef
Externí odkaz:
https://doaj.org/article/010906a9f19b493eb18dbcddbbcc7354
Autor:
Mareike Rentzsch, Robert Wawrzinek, Claudia Zelle-Rieser, Helen Strandt, Lydia Bellmann, Felix F. Fuchsberger, Jessica Schulze, Jil Busmann, Juliane Rademacher, Stephan Sigl, Barbara Del Frari, Patrizia Stoitzner, Christoph Rademacher
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immune modulating therapies and vaccines are in high demand, not least to the recent global spread of SARS-CoV2. To achieve efficient activation of the immune system, professional antigen presenting cells have proven to be key coordinators of such re
Externí odkaz:
https://doaj.org/article/e31a5a90189840738b7687431502dac3
Autor:
Eike-Christian Wamhoff, Jessica Schulze, Lydia Bellmann, Mareike Rentzsch, Gunnar Bachem, Felix F. Fuchsberger, Juliane Rademacher, Martin Hermann, Barbara Del Frari, Rob van Dalen, David Hartmann, Nina M. van Sorge, Oliver Seitz, Patrizia Stoitzner, Christoph Rademacher
Publikováno v:
ACS Central Science, Vol 5, Iss 5, Pp 808-820 (2019)
Externí odkaz:
https://doaj.org/article/b243f0a6863149e4926bb2729fa8b4e5
Autor:
Anastasia Prokopi, Christoph H Tripp, Bart Tummers, Florian Hornsteiner, Sarah Spoeck, Jeremy Chase Crawford, Derek R Clements, Mirjana Efremova, Katharina Hutter, Lydia Bellmann, Giuseppe Cappellano, Bruno L Cadilha, Daniela Ortner, Zlatko Trajanoski, Suzie Chen, Juliana Idoyaga, Douglas R Green, Patrizia Stoitzner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment. A lack of tumor-infiltrating T cells is a common reason for therapy failure but als
Externí odkaz:
https://doaj.org/article/66831436d29b40f3abee1e0b88929637
Autor:
Lisa Pipperger, Lydia Riepler, Janine Kimpel, Anita Siller, Patrizia Stoitzner, Zoltán Bánki, Dorothee von Laer
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Oncolytic viruses (OVs) can eradicate tumor cells and elicit antitumor immunity. VSV-GP, a chimeric vesicular stomatitis virus (VSV) with the glycoprotein (GP) of the lymphocytic choriomeningitis virus, is a promising new OV candidate. However, the i
Externí odkaz:
https://doaj.org/article/82fd02b7598445fa861025ab33611140
Autor:
Claudia Zelle-Rieser, Shanmugapriya Thangavadivel, Rainer Biedermann, Andrea Brunner, Patrizia Stoitzner, Ella Willenbacher, Richard Greil, Karin Jöhrer
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-12 (2016)
Abstract Background Multiple myeloma is an incurable plasma cell malignancy that is mostly restricted to the bone marrow. Cancer-induced dysfunction of cytotoxic T cells at the tumor site may be responsible for immune evasion and therapeutical failur
Externí odkaz:
https://doaj.org/article/7fe237966f4b4c21ae71107013132c54
Autor:
Florian Sparber, Tamas Dolowschiak, Sarah Mertens, Laura Lauener, Björn E Clausen, Nicole Joller, Patrizia Stoitzner, Roxane Tussiwand, Salomé LeibundGut-Landmann
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007069 (2018)
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 is crucial for protective immunity against
Externí odkaz:
https://doaj.org/article/a54913a11f8a4e03926a8002bb2197f5