Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Patrizia Sini"'
Autor:
Maria Gabriela Raso, Elizve Barrientos Toro, Kurt Evans, Yasmeen Rizvi, Rossana Lazcano, Argun Akcakanat, Patrizia Sini, Francesca Trapani, Eva Johanna Madlener, Lorenz Waldmeier, Alexander Lazar, Funda Meric-Bernstam
Publikováno v:
Cancers, Vol 16, Iss 10, p 1874 (2024)
The Wnt receptor ROR1 has generated increased interest as a cancer therapeutic target. Research on several therapeutic approaches involving this receptor is ongoing; however, ROR1 tissue expression remains understudied. We performed an immunohistoche
Externí odkaz:
https://doaj.org/article/89b8af7b92684a4ca120e10fd73c8982
Autor:
Nolt, Georgia L., Keeble, Alexander R., Wen, Yuan, Strong, Aubrey C., Thomas, Nicholas T., Valentino, Taylor R., Brightwell, Camille R., Murach, Kevin A., Patrizia, Sini, Weinstabl, Harald, Gollner, Andreas, McCarthy, John J., Fry, Christopher S., Franti, Michael, Filareto, Antonio, Peterson, Charlotte A., Dungan, Cory M.
Publikováno v:
GeroScience; Apr2024, Vol. 46 Issue 2, p2153-2176, 24p
Akademický článek
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Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
Chemical structure of BI 811283: 2,3-diamino-pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b569a67ee6db1fdbb4b9b9898d09fa
https://doi.org/10.1158/1535-7163.22503072
https://doi.org/10.1158/1535-7163.22503072
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
Supplementary Table S1: Statistics of data collection and processing of AuroraB/INCENP in complex with BI 847325; Supplementary Table S2: Statistics of data collection and processing of MEK1 in complex with BI 847325; Supplementary Table S3: Statisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a674f9a24129289384fc2594456c5203
https://doi.org/10.1158/1535-7163.22503057
https://doi.org/10.1158/1535-7163.22503057
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364401e0cf33e13f4ddf75ae3b69dd1f
https://doi.org/10.1158/1535-7163.22503066.v1
https://doi.org/10.1158/1535-7163.22503066.v1
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea465e8bb386c7526ee890a39c10857
https://doi.org/10.1158/1535-7163.22503069.v1
https://doi.org/10.1158/1535-7163.22503069.v1
Supplemental Tables 1 and 2 and Figures 1-3. Supplemental Table 1: Cell line resistance mechanisms Supplemental Table 2: Ic50 values for BI-847325 on the cell line panel Supplemental Figure 1: BI-847325 blocks the proliferation and induces apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbe5dde029972b28d89600a06c918c1
https://doi.org/10.1158/1535-7163.22500744
https://doi.org/10.1158/1535-7163.22500744
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7900c0b469b7183181eea3504d39d1
https://doi.org/10.1158/1535-7163.22503063
https://doi.org/10.1158/1535-7163.22503063
Resistance to BRAF inhibitors is a major clinical problem. Here, we evaluate BI-847325, an ATP-competitive inhibitor of MEK and Aurora kinases, in treatment-naïve and drug-resistant BRAF-mutant melanoma models. BI-847325 potently inhibited growth an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e25e06a72d86bcb8af487c9c422055
https://doi.org/10.1158/1535-7163.c.6536562.v1
https://doi.org/10.1158/1535-7163.c.6536562.v1