Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Patrizia Sciancalepore"'
Autor:
Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore, Giorgia Mandili, Myriam Foglietta, Nico Mitro, Donatella Caruso, Francesco Novelli, Chiara Riganti, Massimo Massaia
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
γδT cells are activated by phosphoantigens, and ABCA1 is involved in cholesterol transport. Here the authors link these ideas to show that ABCA1, apoA-I and BTN3A1 regulate extracellular phosphoantigen release by dendritic cells, and implicate ABCA
Externí odkaz:
https://doaj.org/article/30ff31dddf594bef8c44c2fafe50d420
Autor:
Barbara Castella, Myriam Foglietta, Patrizia Sciancalepore, Micol Rigoni, Marta Coscia, Valentina Griggio, Candida Vitale, Riccardo Ferracini, Elona Saraci, Paola Omedé, Chiara Riganti, Antonio Palumbo, Mario Boccadoro, Massimo Massaia
Publikováno v:
OncoImmunology, Vol 4, Iss 11 (2015)
Vγ9Vδ2 T cells have a natural inclination to recognize malignant B cells in vitro via receptors for stress-induced self-ligands and TCR-dependent recognition of phosphoantigens (pAgs) generated in the mevalonate (Mev) pathway. This inclination is c
Externí odkaz:
https://doaj.org/article/a3fe743dd0a944269c5db8dd6d65fde3
Autor:
Marta Robino, Valentina Griggio, Barbara Castella, Marco Ladetto, Ilaria Buondonno, Daniela Drandi, Mario Boccadoro, Ivana Campia, Massimo Massaia, Candida Vitale, Chiara Riganti, Patrizia Sciancalepore, Micol Maria Rigoni, Marta Coscia, Myriam Foglietta
Publikováno v:
Oncotarget
The immunoglobulin heavy-chain variable region (IGHV) mutational status is a strong determinant of remission duration in chronic lymphocytic leukemia (CLL). The aim of this work was to compare the multidrug resistance (MDR) signature of IGHV mutated
Autor:
Francesco Novelli, Massimo Massaia, Donatella Caruso, Myriam Foglietta, Giorgia Mandili, Barbara Castella, Nico Mitro, Joanna Kopecka, Patrizia Sciancalepore, Chiara Riganti
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms. Here w
Autor:
Patrizia Sciancalepore, Massimo Massaia, Candida Vitale, Chiara Riganti, Micol Maria Rigoni, Elona Saraci, Mario Boccadoro, Riccardo Ferracini, Barbara Castella, Antonio Palumbo, Myriam Foglietta, Valentina Griggio, Paola Omedè, Marta Coscia
Publikováno v:
Oncoimmunology
Vγ9Vδ2 T cells have a natural inclination to recognize malignant B cells in vitro via receptors for stress-induced self-ligands and TCR-dependent recognition of phosphoantigens (pAgs) generated in the mevalonate (Mev) pathway. This inclination is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7b44017d03398a6e0ab271cd985f16
http://hdl.handle.net/2318/1526510
http://hdl.handle.net/2318/1526510
Autor:
Massimo Massaia, Micol Maria Rigoni, Patrizia Sciancalepore, Mario Boccadoro, Marta Robino, Myriam Foglietta, Ivana Campia, Chiara Riganti, Candida Vitale, Valentina Griggio, Barbara Castella, Marta Coscia
BACKGROUND: Treatment of fludarabine-resistant chronic lymphocytic leukemia (CLL) patients is an unmet clinical need. Fludarabine resistance in CLL depends on intrinsic molecular features of the tumor cells, and on bidirectional interactions occurrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4aa6d744f6791933df755677f6ac50
http://hdl.handle.net/2318/155960
http://hdl.handle.net/2318/155960
Autor:
Donatella Caruso, Massimo Massaia, Francesco Novelli, Joanna Kopecka, Chiara Riganti, Giorgia Mandili, Barbara Castella, Myriam Foglietta, Nico Mitro, Patrizia Sciancalepore, Mario Boccadoro, Ezio Tripoli
Publikováno v:
Blood. 128:3709-3709
Introduction Phosphorylated metabolites of mevalonate (Mev) pathway like isopentenyl-pyrophosphate (IPP) induce proliferation of Vγ9Vδ2 T cells. Endogenous IPP levels can be lowered or increased by aminobisphosphonates (NBPs) such as zoledronic aci
Autor:
Patrizia Sciancalepore, Mario Boccadoro, Ezio Tripoli, Massimo Massaia, Myriam Foglietta, Barbara Castella
Publikováno v:
Blood. 128:2059-2059
Tumor cells exploit immune checkpoints to withstand immune recognition and effector cells' onslaught. Pre-clinical findings, corroborated by initial results of clinical studies, indicate that immune checkpoint blockade is a promising strategy to harn
Autor:
Barbara Castella, Daniela Drandi, Ivana Campia, Valentina Griggio, Chiara Riganti, Candida Vitale, Maria Elisa Canepari, Marta Robino, Mario Boccadoro, Massimo Massaia, Marta Coscia, Myriam Foglietta, Amalia Bosia, Micol Maria Rigoni, Patrizia Sciancalepore, Marco Ladetto
Abstract 3881 Background: The mutational status of tumor immunoglobulin heavy chain variable region (IGHV) is a reliable prognosticator in chronic lymphocytic leukemia (CLL): patients with unmutated (UM) IGHV have a worse prognosis than patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d9249d36cc50f1b4ff849ea6f1eaaa
http://hdl.handle.net/2318/132217
http://hdl.handle.net/2318/132217
Autor:
Patrizia Sciancalepore, Marta Robino, Federica Linty, Candida Vitale, Marina Ruggeri, Myriam Foglietta, Micol Maria Rigoni, Valentina Griggio, Paola Cappello, Marco Ladetto, Giorgia Mandili, Barbara Castella, Michela Capello, Massimo Massaia, Daniela Drandi, Mario Boccadoro, Paola Omedè, Marta Coscia, Francesco Novelli
Abstract 3878 Introduction: In this study, a serological proteome analysis (SERPA) was applied for the first time to identify novel tumor-associated antigens (Ags) capable of eliciting humoral immune responses in patients with chronic lymphocytic leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d56f0d9182843e6ea7879f4d22b852
http://hdl.handle.net/2318/131643
http://hdl.handle.net/2318/131643