Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Patrizia M Novello"'
Autor:
Christopher J. Burns, Ian P. Wicks, Patrizia M Novello, David J. Segal, Devi Ngo, Helene Jousset, Cynthia Louis, Louisa J. Phillipson, Jacinta Hansen, Kate E. Lawlor, Damian B D'Silva
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 71(1)
Objective The production of class-switched high-affinity autoantibodies derived from organized germinal centers (GCs) is a hallmark of many autoimmune inflammatory diseases, including rheumatoid arthritis (RA). TANK-binding kinase 1 (TBK-1) is a seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dcd3f36c74b0b0a5e46a61fe883e87
https://pubmed.ncbi.nlm.nih.gov/30009417
https://pubmed.ncbi.nlm.nih.gov/30009417
Autor:
Ian P. Street, Jonathan B. Baell, Keith G. Watson, R.C.A. Thompson, Georgina A Holloway, Tanya Armstrong, Patrizia M Novello, John P Parisot
Publikováno v:
ChemInform. 41
A benzhydryl tropinone oxime that is potently toxic to Trypanosoma cruzi has been previously identified. An SAR investigation determined that no part of the original compound was superfluous and all early SAR probes led to significant drops in activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff55d9fb8bde740f53be0834178d3668
https://doi.org/10.1002/chin.201029222
https://doi.org/10.1002/chin.201029222
Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi
Autor:
Jonathan B. Baell, Ian P. Street, John P Parisot, Georgina A Holloway, Keith G. Watson, Tanya Armstrong, Patrizia M Novello, R.C.A. Thompson
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
A benzhydryl tropinone oxime that is potently toxic to Trypanosoma cruzi has been previously identified. An SAR investigation determined that no part of the original compound was superfluous and all early SAR probes led to significant drops in activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882493ef50d5ba2ef104f54a6fb7350c
https://pubmed.ncbi.nlm.nih.gov/20185305
https://pubmed.ncbi.nlm.nih.gov/20185305
Autor:
Ian P. Street, Edmund Kostewicz, Alan H. Fairlamb, John L. Richardson, John P Parisot, Georgina A Holloway, Patrizia M Novello, Marcel Kaiser, Jonathan B. Baell, William N. Charman, Reto Brun, Keith G. Watson
Publikováno v:
Antimicrobial agents and chemotherapy. 53(7)
High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation. Hits from five of these chemical classes have been developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707074541dc05354b920912ee4e3fa61
https://pubmed.ncbi.nlm.nih.gov/19364854
https://pubmed.ncbi.nlm.nih.gov/19364854
Autor:
Ian P. Street, Alan H. Fairlamb, Jonathan B. Baell, Patrizia M Novello, Keith G. Watson, John L. Richardson, John P Parisot, Georgina A Holloway
A high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles as a novel class of trypanothione reductase inhibitors. These 2-iminobenzimidazoles display potent trypanocidal activity against Trypano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8fe8e7aec38b3fc0bbd8645f777ba7
https://europepmc.org/articles/PMC3428904/
https://europepmc.org/articles/PMC3428904/
