Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

Autor: C. Fessler, S.-H. Kim, Christopher Janus, L. Yang, G. Gray, T. Riff, Nina Hoque, Cathy A. Andorfer, Richard E. Olson, P. Y. A. Wong, J. Protassio, L. B. DeCarr, V. Liu, Sethu Sankaranarayanan, F. Y. Lee, Donna M. Barten, J. E. Meredith, G. W. Cadelina, Amanda Hanna, C. Polson, G. D. Vite, H. Turner, Charles F. Albright, Kristofor H. Husted, Patrizia Fanara

Publikováno v: The Journal of Neuroscience. 32:7137-7145

Tau is a microtubule (MT)-stabilizing protein that is altered in Alzheimer's disease (AD) and other tauopathies. It is hypothesized that the hyperphosphorylated, conformationally altered, and multimeric forms of tau lead to a disruption of MT stabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48497ab202ecf661faaee61228f2327e
https://doi.org/10.1523/jneurosci.0188-12.2012

Stabilization of Hyperdynamic Microtubules Is Neuroprotective in Amyotrophic Lateral Sclerosis

Autor: Holly Turner, Macha R. Harper, Roland Brandt, Kristofor H. Husted, Mohamad Awada, Patrizia Fanara, Jayee Banerjee, Marc K. Hellerstein, Rommel V. Hueck

Publikováno v: Journal of Biological Chemistry. 282:23465-23472

Mutations in copper/zinc superoxide dismutase 1 (SOD1), a genetic cause of human amyotrophic lateral sclerosis, trigger motoneuron death through unknown toxic mechanisms. We report that transgenic SOD1G93A mice exhibit striking and progressive change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307c7d137a2ac5a11b983d1503d63ee5
https://doi.org/10.1074/jbc.m703434200

The Auto-inhibitory Function of Importin α Is Essentialin Vivo

Autor: Alec E. Hodel, Michelle T. Harreman, Patrizia Fanara, Anita H. Corbett, Mary R. Hodel

Publikováno v: Journal of Biological Chemistry. 278:5854-5863

Proteins that contain a classical nuclear localization signal (NLS) are recognized in the cytoplasm by a heterodimeric import receptor composed of importin/karyopherin alpha and beta. The importin alpha subunit recognizes classical NLS sequences, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988ca25281a4f09be33c23b3909606a1
https://doi.org/10.1074/jbc.m210951200

Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration

Autor: Timothy Riiff, Lori A. Kohlstaedt, Joan C. Protasio, Richard W. Price, Salena Killion, Lorrie Epling, Marc K. Hellerstein, Shanshan Liu, Drina Boban, Chadwick W. Christine, Patrizia Fanara, Victoria M. Liu, Po-Yin A. Wong, Julia Peterson, Roland Brandt, Elisabeth Sinclair, Maudi Killian, Robert L. Nussbaum, Deborah E. Cabin, Jörg Brühmann, Michael J. Aminoff, Kristofor H. Husted

Publikováno v: Fanara, P; Wong, PYA; Husted, KH; Liu, S; Liu, VM; Kohlstaedt, LA; et al.(2012). Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. Journal of Clinical Investigation, 122(9), 3159-3169. doi: 10.1172/JCI64575. UCSF: Retrieved from: http://www.escholarship.org/uc/item/673172sc
The Journal of clinical investigation, vol 122, iss 9

Progress in neurodegenerative disease research is hampered by the lack of biomarkers of neuronal dysfunction. We here identified a class of cerebrospinal fluid-based (CSF-based) kinetic biomarkers that reflect altered neuronal transport of protein ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f1c7cf98e49fa2fb71abefb6960e9e
http://www.escholarship.org/uc/item/673172sc

Identification of MINUS, a small polypeptide that functions as a microtubule nucleation suppressor

Autor: Roland Brandt, Alexandre V. Podtelejnikov, Björn Oback, Keith Ashman, Patrizia Fanara

Publikováno v: Fanara, P, Oback, B, Ashmann, K, Podtelejnikov, A & Brandt, R 1999, ' Identification of MINUS, a small polypeptide that functions as a microtubule nucleation suppressor ', EMBO Journal, vol. 18, pp. 565-577 .

In eukaryotic cells, tubulin polymerization must be regulated precisely during cell division and differentiation. To identify new mechanisms involved in cellular microtubule formation, we isolated an activity that suppresses microtubule nucleation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad920f9ad2a9d8c895f523920a385a33
https://pubmed.ncbi.nlm.nih.gov/9927416