Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Patrizia Borsotti"'
Autor:
Andrea Resovi, Perla Persichitti, Laura Brunelli, Lucia Minoli, Patrizia Borsotti, Giulia Garattini, Matteo Tironi, Erica Dugnani, Miriam Redegalli, Giulia De Simone, Roberta Pastorelli, Maria Rosa Bani, Lorenzo Piemonti, Deane F. Mosher, Raffaella Giavazzi, Giulia Taraboletti, Dorina Belotti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background The pancreatic microenvironment has a defensive role against cancer but it can acquire tumor-promoting properties triggered by multiple mechanisms including alterations in the equilibrium between proteases and their inhibitors. Th
Externí odkaz:
https://doaj.org/article/4bc68fabcf3a4866bfd7e59ee7c138f6
Autor:
Andrea Resovi, Patrizia Borsotti, Tommaso Ceruti, Alice Passoni, Massimo Zucchetti, Alexander Berndt, Bruce L. Riser, Giulia Taraboletti, Dorina Belotti
Publikováno v:
Cells, Vol 9, Iss 4, p 952 (2020)
The prominent desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a determinant factor in tumor progression and a major barrier to the access of chemotherapy. The PDAC microenvironment therefore appears to be a promising therapeutic tar
Externí odkaz:
https://doaj.org/article/814b2712dc644b48b6b7bb898871a43d
Autor:
Katiuscia Bonezzi, Dorina Belotti, Brian J. North, Carmen Ghilardi, Patrizia Borsotti, Andrea Resovi, Paolo Ubezio, Antonella Riva, Raffaella Giavazzi, Eric Verdin, Giulia Taraboletti
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 9, Pp 846-854 (2012)
Taxanes are potent inhibitors of cell motility, a property implicated in their antiangiogenic and antimetastatic activity and unrelated to their antiproliferative effect. The molecular mechanism of this anti-motility activity is poorly understood. In
Externí odkaz:
https://doaj.org/article/324bba01ddad45f9bda06f2d628005cb
Autor:
Giulia Taraboletti, Sandra D'Ascenzoy, Ilaria Giusti, Daniela Marchetti, Patrizia Borsotti, Danilo Millimaggi, Raffaella Giavazzi, Antonio Pavan, Vincenza Dolo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 2, Pp 96-103 (2006)
Tumor angiogenesis is regulated by a dynamic crosstalk between tumor cells and the host microenvironment. Because membrane vesicles shed by tumor cells are known to mediate several tumor—host interactions, we determined whether vesicles might also
Externí odkaz:
https://doaj.org/article/db6deeb5e84645ebad82eeab5f79fdb7
Autor:
Andrea Resovi, Patrizia Borsotti, Fabio Sangalli, Enrico Davoli, Alexander Berndt, Lorena Zentilin, Massimo Zucchetti, Raffaella Giavazzi, Alice Passoni, Dorina Belotti, Giovanni Valbusa, Denise Pinessi, Mauro Giacca, Giulia Taraboletti, Lavinia Morosi, Elena Carlessi
Publikováno v:
Matrix Biology. :22-36
The disorganized and inefficient tumor vasculature is a major obstacle to the delivery and efficacy of antineoplastic treatments. Antiangiogenic agents can normalize the tumor vessels, improving vessel function and boosting the distribution and activ
Autor:
Dorina Belotti, Massimo Zucchetti, Andrea Resovi, Patrizia Borsotti, Alexander Berndt, Bruce L Riser, Giulia Taraboletti, Alice Passoni, Tommaso Ceruti
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 952, p 952 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 952, p 952 (2020)
The prominent desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a determinant factor in tumor progression and a major barrier to the access of chemotherapy. The PDAC microenvironment therefore appears to be a promising therapeutic tar
Autor:
Maria E. Riveiro, David Gould, Keyvan Rezai, Giulia Taraboletti, Yuti Chernajovsky, Marina Meroni, Massimo Russo, Patrizia Borsotti, Roberta Frapolli, Christopher Schultz
Publikováno v:
Cancer Research. 81:916-916
Background. Recombinant IL-2 (rIL-2; aldesleukin) has consistently shown single agent responses and survival benefits in metastatic melanoma and renal cell carcinoma. However, severe toxic side effects associated with high doses, as well as the poor
Autor:
Antonella Bugatti, Denise Pinessi, Giorgio Colombo, Giulia Paiardi, Giulia Taraboletti, Deane F. Mosher, Paola Chiodelli, Douglas S. Annis, Alessandro Gori, Elisabetta Moroni, Dorina Belotti, Patrizia Borsotti, Laura Carminati, Chiara Foglieni, Marco Rusnati, Renato Longhi
Publikováno v:
Angiogenesis (Dordr., Online) 22 (2019): 133–144. doi:10.1007/s10456-018-9644-3
info:cnr-pdr/source/autori:Rusnati M.; Borsotti P.; Moroni E.; Foglieni C.; Chiodelli P.; Carminati L.; Pinessi D.; Annis D.S.; Paiardi G.; Bugatti A.; Gori A.; Longhi R.; Belotti D.; Mosher D.F.; Colombo G.; Taraboletti G./titolo:The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2)/doi:10.1007%2Fs10456-018-9644-3/rivista:Angiogenesis (Dordr., Online)/anno:2019/pagina_da:133/pagina_a:144/intervallo_pagine:133–144/volume:22
info:cnr-pdr/source/autori:Rusnati M.; Borsotti P.; Moroni E.; Foglieni C.; Chiodelli P.; Carminati L.; Pinessi D.; Annis D.S.; Paiardi G.; Bugatti A.; Gori A.; Longhi R.; Belotti D.; Mosher D.F.; Colombo G.; Taraboletti G./titolo:The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2)/doi:10.1007%2Fs10456-018-9644-3/rivista:Angiogenesis (Dordr., Online)/anno:2019/pagina_da:133/pagina_a:144/intervallo_pagine:133–144/volume:22
Thrombospondin (TSP)-1 and TSP-2 share similar structures and functions, including a remarkable antiangiogenic activity. We have previously demonstrated that a mechanism of the antiangiogenic activity of TSP-1 is the interaction of its type III repea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ca2338121360f320faba713901f669
http://www.cnr.it/prodotto/i/400593
http://www.cnr.it/prodotto/i/400593
Autor:
Giulia Taraboletti, Denise Pinessi, Laura Carminati, Raffaella Giavazzi, Lucia Minoli, Dorina Belotti, Maurizio D'Incalci, Patrizia Borsotti
Publikováno v:
Carcinogenesis. 40(2)
Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenviro
Autor:
Denise Pinessi, Andrea Resovi, Patrizia Borsotti, Francesca Bizzaro, Giulia Taraboletti, Giovanna Chiorino, Ezia Bello, Federica Guffanti, Maria Rosa Bani, Paola Ostano, Roberta Frapolli
Publikováno v:
Connective Tissue Research. 56:355-363
Thrombospondin-1 (TSP-1), a major regulator of cell interaction with the environment, is often deregulated in cancers, including ovarian carcinoma. Both the tumor and the host cells can release TSP-1 in the tumor microenvironment. The relative contri