Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Patrizia Benzoni"'
1
Akademický článek
PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes
Autor: Patrizia Benzoni, Lorenzo Da Dalt, Noemi Elia, Vera Popolizio, Alessandro Cospito, Federica Giannetti, Patrizia Dell’Era, Morten S. Olesen, Annalisa Bucchi, Mirko Baruscotti, Giuseppe Danilo Norata, Andrea Barbuti
Publikováno v: Frontiers in Physiology, Vol 14 (2023)
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide; however, the underlying causes of AF initiation are still poorly understood, particularly because currently available models do not allow in distinguishing the initial causes f
Externí odkaz: https://doaj.org/article/eb6bd6e9abc74426a70134e06381e27b
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2
Akademický článek
Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes
Autor: Marzia De Bortoli, Viviana Meraviglia, Katarina Mackova, Laura S. Frommelt, Eva König, Johannes Rainer, Chiara Volani, Patrizia Benzoni, Maja Schlittler, Giada Cattelan, Benedetta M. Motta, Claudia Volpato, Werner Rauhe, Andrea Barbuti, Serena Zacchigna, Peter P. Pramstaller, Alessandra Rossini
Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1759-1773 (2023)
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are commonly used to model arrhythmogenic cardiomyopathy (ACM), a heritable cardiac disease characterized by severe ventricular arrhythmias, fibrofatty myocardial replacement and
Externí odkaz: https://doaj.org/article/2220b6b3a2c54765af91e30f1c2ec426
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3
Akademický článek
Generation of human induced pluripotent stem cells (EURACi001-A, EURACi002-A, EURACi003-A) from peripheral blood mononuclear cells of three patients carrying mutations in the CAV3 gene
Autor: Viviana Meraviglia, Patrizia Benzoni, Sara Landi, Carmen Murano, Marianna Langione, Benedetta M. Motta, Serena Baratto, Rosamaria Silipigni, Marina Di Segni, Peter P. Pramstaller, Dario DiFrancesco, Elisabetta Gazzerro, Andrea Barbuti, Alessandra Rossini
Publikováno v: Stem Cell Research, Vol 27, Iss , Pp 25-29 (2018)
Caveolinopathies are a heterogeneous family of genetic pathologies arising from alterations of the caveolin-3 gene (CAV3), encoding for the isoform specifically constituting muscle caveolae. Here, by reprogramming peripheral blood mononuclear cells,
Externí odkaz: https://doaj.org/article/6e812861cadc46bfa75010c1bf6d5fc8
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4
Akademický článek
Generation of the induced human pluripotent stem cell lines CSSi009-A from a patient with a GNB5 pathogenic variant, and CSSi010-A from a CRISPR/Cas9 engineered GNB5 knock-out human cell line
Autor: Natascia Malerba, Patrizia Benzoni, Gabriella Maria Squeo, Raffaella Milanesi, Federica Giannetti, Lynette G. Sadleir, Gemma Poke, Bartolomeo Augello, Anna Irma Croce, Andrea Barbuti, Giuseppe Merla
Publikováno v: Stem Cell Research, Vol 40, Iss , Pp - (2019)
GNB5 loss-of-function pathogenic variants cause IDDCA, a rare autosomal recessive human genetic disease characterized by infantile onset of intellectual disability, sinus bradycardia, hypotonia, visual abnormalities, and epilepsy. We generated human
Externí odkaz: https://doaj.org/article/7e6ca3fb95ff4982867323666b32b676
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7
Data from Antiangiogenic Activity of a Neutralizing Human Single-Chain Antibody Fragment against Fibroblast Growth Factor Receptor 1
Autor: Patrizia Dell'Era, Marco Presta, Stefano Calza, Daniela Coltrini, Patrizia Alessi, Michela Corsini, Mirella Belleri, Chiara Urbinati, Daria Leali, Patrizia Benzoni, Roberto Ronca
Fibroblast growth factor receptor-1 (FGFR-1) transduces proangiogenic and proliferative signals in human cancers. Thus, FGFR-1 may represent a target for the development of antiangiogenic/antineoplastic therapies. We screened a human single-chain fra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148043a51389b9be7583a2a7b6f5214b
https://doi.org/10.1158/1535-7163.c.6531530
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9
A detailed characterization of the hyperpolarization-activated 'funny' current (If) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity
Autor: Alessandra Rossini, Raffaella Milanesi, Patrizia Dell'Era, Andrea Barbuti, Mirko Baruscotti, Patrizia Benzoni, Annalisa Bucchi, Federica Giannetti, Giulia Campostrini
Publikováno v: Pflügers Archiv - European Journal of Physiology. 473:1009-1021
Properties of the funny current (If) have been studied in several animal and cellular models, but so far little is known concerning its properties in human pacemaker cells. This work provides a detailed characterization of If in human-induced pluripo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633299c285ba05862fce0c60c79b62ab
https://doi.org/10.1007/s00424-021-02571-w
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10
When multiple caveolins make the difference: Cav1 partly compensates Cav3 alterations and rescues ion channels expression
Autor: A Rossini, Federica Giannetti, Annalisa Bucchi, A Cospito, Patrizia Benzoni, Mirko Baruscotti, Andrea Barbuti
Publikováno v: EP Europace. 23
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Fondazione Cariplo Caveolae are small-membrane invagination that contribute both to buffering excessive contraction-dependent membrane strain and to initiation of m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e19910ec7b570f70eb97912e2ab150c5
https://doi.org/10.1093/europace/euab116.535
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