Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Patrizia Agostinis"'
Autor:
Paloma García Casas, Michela Rossini, Linnea Påvénius, Mezida Saeed, Nikita Arnst, Sonia Sonda, Tânia Fernandes, Irene D’Arsiè, Matteo Bruzzone, Valeria Berno, Andrea Raimondi, Maria Livia Sassano, Luana Naia, Elisa Barbieri, Sara Sigismund, Patrizia Agostinis, Mattia Sturlese, Barbara A. Niemeyer, Hjalmar Brismar, Maria Ankarcrona, Arnaud Gautier, Paola Pizzo, Riccardo Filadi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites and their small size hinder analysis by current imaging techniques. To overcome these limitations, we h
Externí odkaz:
https://doaj.org/article/0b6b5bb0acb9468497829472faf67a2f
Autor:
Jelle Verhoeven, Kathryn A Jacobs, Francesca Rizzollo, Francesca Lodi, Yichao Hua, Joanna Poźniak, Adhithya Narayanan Srinivasan, Diede Houbaert, Gautam Shankar, Sanket More, Marco B Schaaf, Nikolina Dubroja Lakic, Maarten Ganne, Jochen Lamote, Johan Van Weyenbergh, Louis Boon, Oliver Bechter, Francesca Bosisio, Yasuo Uchiyama, Mathieu JM Bertrand, Jean Christophe Marine, Diether Lambrechts, Gabriele Bergers, Madhur Agrawal, Patrizia Agostinis
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-25 (2023)
Abstract Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune‐excluded tumor phenotype. However, the molecular mechanisms that sustain TEC‐mediated immunosuppression remain largely elusive. Here, we show t
Externí odkaz:
https://doaj.org/article/bbcea8700d3946d0a54b3724c68d12c4
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAberrant reactive oxygen species (ROS) production is one of the hallmarks of cancer. During their growth and dissemination, cancer cells control redox signaling to support protumorigenic pathways. As a consequence, cancer cells become rel
Externí odkaz:
https://doaj.org/article/51648ebd66524c48826526b1a807c73d
Autor:
Diede Houbaert, Apostolos Panagiotis Nikolakopoulos, Kathryn A. Jacobs, Odeta Meçe, Jana Roels, Gautam Shankar, Madhur Agrawal, Sanket More, Maarten Ganne, Kristine Rillaerts, Louis Boon, Magdalena Swoboda, Max Nobis, Larissa Mourao, Francesca Bosisio, Niels Vandamme, Gabriele Bergers, Colinda L.G.J. Scheele, Patrizia Agostinis
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114020- (2024)
Summary: Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to immunotherapy largely rely on peripheral T cell recruitment in tumors. Yet, a systemat
Externí odkaz:
https://doaj.org/article/dca7f3404ac04b61a443f7d540320e6d
Autor:
Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Mélanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O’Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V. Swinnen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Background One of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance. Taking BRAF-mutant melanoma as paradigm, we previously identified the lipogenic regulator SREBP-1 as a central mediator of resistanc
Externí odkaz:
https://doaj.org/article/8829970c22234a53b950a2b7f4311f51
Autor:
Maria Vedunova, Victoria Turubanova, Olga Vershinina, Maria Savyuk, Iuliia Efimova, Tatiana Mishchenko, Robrecht Raedt, Anne Vral, Christian Vanhove, Daria Korsakova, Claus Bachert, Frauke Coppieters, Patrizia Agostinis, Abhishek D. Garg, Mikhail Ivanchenko, Olga Krysko, Dmitri V. Krysko
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-19 (2022)
Abstract Gliomas, the most frequent type of primary tumor of the central nervous system in adults, results in significant morbidity and mortality. Despite the development of novel, complex, multidisciplinary, and targeted therapies, glioma therapy ha
Externí odkaz:
https://doaj.org/article/229b8aa3d4d949289dbd38fbfc39ad30
Autor:
Odeta Meçe, Diede Houbaert, Maria-Livia Sassano, Tania Durré, Hannelore Maes, Marco Schaaf, Sanket More, Maarten Ganne, Melissa García-Caballero, Mila Borri, Jelle Verhoeven, Madhur Agrawal, Kathryn Jacobs, Gabriele Bergers, Silvia Blacher, Bart Ghesquière, Mieke Dewerchin, Johan V. Swinnen, Stefan Vinckier, María S. Soengas, Peter Carmeliet, Agnès Noël, Patrizia Agostinis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Autophagy is essential to endothelial cell homeostasis. Here the authors show that lipophagy in LEC supports fatty acid oxidation to sustain a mitochondrial-Prox1 gene expression circuit and promote response of LEC to lymphangiogenic mediators.
Externí odkaz:
https://doaj.org/article/6f053768112c4a3e957fc921d9943221
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Membrane contact sites (MCS) between organelles of eukaryotic cells provide structural integrity and promote organelle homeostasis by facilitating intracellular signaling, exchange of ions, metabolites and lipids and membrane dynamics. Cataloguing MC
Externí odkaz:
https://doaj.org/article/f47c993be6464007b05356d9987b794c
Autor:
Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johannes V. Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas this may initiate disease in familial cases, onset in sporadic diseases may originate from a gradually disrupted organellar homeostasis. Herein, endolysosomal abnor
Externí odkaz:
https://doaj.org/article/71b18339eb854ed494b75e0a5a5c3764
Publikováno v:
Contact, Vol 4 (2021)
We recently reported that the ER stress kinase PERK regulates ER-mitochondria appositions and ER– plasma membrane (ER-PM) contact sites, independent of its canonical role in the unfolded protein response. PERK regulation of ER-PM contacts was revea
Externí odkaz:
https://doaj.org/article/4b8cb40e914a445b8dafa682523ff4db