High rate of durable responses with undetectable minimal residual disease with front-line venetoclax and rituximab in young, fit patients with chronic lymphocytic leukemia and an adverse biological profile: results of the GIMEMA phase II LLC1518 - VERITAS study.

Autor: Mauro FR; Hematology, Department of Translational and Precision Medicine, Sapienza University. mauro@bce.uniroma1.it., Starza ID; Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome; GIMEMA Foundation., Messina M; GIMEMA Foundation., Reda G; Hematology Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan., Trentin L; Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua., Coscia M; Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino., Sportoletti P; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato Oncologica (CREO), University of Perugia, Perugia., Orsucci L; Department of Hematology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino., Arena V; GIMEMA Foundation., Casaluci GM; Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale and AOU Maggiore della Carità, Novara., Marasca R; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia., Murru R; Hematology and Stem Cell Transplantation Unit, Ospedale A. Businco, ARNAS 'G. Brotzu', Cagliari., Laurenti L; Fondazione Policlinico Universitario A Gemelli, IRCCS., Ilariucci F; Division of Hematology, Hematology, Arcispedale Santa Maria Nuova, Reggio Emilia., Stelitano C; Department of Hematology, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria., Mannina D; Division of Hematology, Azienda Ospedaliera Papardo, Messina., Massaia M; Division of Hematology, Santa Croce e Carle Hospital, Via Michele Coppino 26, 12100 Cuneo., Rigolin GM; Hematology Section, St. Anna University Hospital, Ferrara., Scarfò L; Strategic Research Program on CLL, IRCCS Ospedale San Raffaele and Università Vita- Salute San Raffaele, Milan., Marchetti M; Hematology and Transplant Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, University of Eastern Pedemont, Alessandria., Levato L; Department of Hematology, Pugliese Ciaccio Hospital, Catanzaro., Tani M; Division of Hematology, Santa Maria delle Croci Hospital, Ravenna., Arcari A; Division of Hematology, Guglielmo da Saliceto Hospital, Piacenza., Musuraca G; Istituto Scientifico Romagnoli per lo Studio e la Cura dei Tumori-IRST, Meldola., Deodato M; ASST Grande Ospedale Metropolitano Niguarda, Milan., Galieni P; Hematology, Mazzoni Hospital, Ascoli Piceno., Patrizi VB; Hematology Department, Umberto I Hospital, Nocera Inferiore (Salerno)., Gottardi D; A.O. Ordine Mauriziano di Torino., Liberati AM; Università degli Studi di Perugia, Azienda Ospedaliera Santa Maria di Terni, Terni., Giordano A; University of Bari 'Aldo Moro,' Hematology and Stem Cell Transplantation Unit, Department of Emergency and Organ Transplantation, Bari., Molinari MC; Hematology, Department of Translational and Precision Medicine, Sapienza University., Pietrasanta D; Hematology and Transplant Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, University of Eastern Pedemont, Alessandria., Mattiello V; Hematology Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan., Visentin A; Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua., Vitale C; Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino., Albano F; University of Bari 'Aldo Moro,' Hematology and Stem Cell Transplantation Unit, Department of Emergency and Organ Transplantation, Bari., Neri A; Hematology Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan., De Novi LA; Hematology, Department of Translational and Precision Medicine, Sapienza University., De Propris MS; Hematology, Department of Translational and Precision Medicine, Sapienza University., Nanni M; Hematology, Department of Translational and Precision Medicine, Sapienza University., Del Giudice I; Hematology, Department of Translational and Precision Medicine, Sapienza University., Guarini A; Hematology, Department of Translational and Precision Medicine, Sapienza University., Fazi P; GIMEMA Foundation., Vignetti M; GIMEMA Foundation., Piciocchi A; GIMEMA Foundation., Cuneo A; Hematology Section, St. Anna University Hospital, Ferrara., Foà R; Hematology, Department of Translational and Precision Medicine, Sapienza University.

Publikováno v: Haematologica [Haematologica] 2023 Aug 01; Vol. 108 (8), pp. 2091-2100. Date of Electronic Publication: 2023 Aug 01.