Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

Autor: Morikawa, H, Ohkura, N, Vandenbon, A, Itoh, M, Nagao Sato, S, Kawaji, H, Lassmann, T, Carninci, P, Hayashizaki, Y, Forrest, Ar, Standley, Dm, Date, H, Sakaguchi, S, FANTOM Consortium (Forrest AR, Rehli, M, Baillie, Jk, de Hoon MJ, Haberle, V, Kulakovskiy, Iv, Lizio, M, Andersson, R, Mungall, Cj, Meehan, Tf, Schmeier, S, Bertin, N, Jørgensen, M, Dimont, E, Arner, E, Schmidl, C, Schaefer, U, Medvedeva, Ya, Plessy, C, Vitezic, M, Severin, J, Semple, Ca, Ishizu, Y, Francescatto, M, Alam, I, Albanese, D, Altschuler, Gm, Archer, Ja, Arner, P, Babina, M, Baker, S, Balwierz, Pj, Beckhouse, Ag, Pradhan Bhatt, S, Blake, Ja, Blumenthal, A, Bodega, B, Bonetti, A, Briggs, J, Brombacher, F, Burroughs, Am, Califano, A, Cannistraci, Cv, Carbajo, D, Chen, Y, Chierici, M, Ciani, Y, Clevers, Hc, Dalla, E, Davis, Ca, Deplancke, B, Detmar, M, Diehl, Ad, Dohi, T, Drabløs, F, Edge, As, Edinger, M, Ekwall, K, Endoh, M, Enomoto, H, Fagiolini, M, Fairbairn, L, Fang, H, Farach Carson MC, Faulkner, Gj, Favorov, Av, Fisher, Me, Frith, Mc, Fujita, R, Fukuda, S, Furlanello, C, Furuno, M, Furusawa, J, Geijtenbeek, Tb, Gibson, A, Gingeras, T, Goldowitz, D, Gough, J, Guhl, S, Guler, R, Gustincich, Stefano, Ha, Tj, Hamaguchi, M, Hara, M, Harbers, M, Harshbarger, J, Hasegawa, A, Hasegawa, Y, Hashimoto, T, Herlyn, M, Hitchens, Kj, Ho Sui SJ, Hofmann, Om, Hoof, I, Hori, F, Huminiecki, L, Iida, K, Ikawa, T, Jankovic, Br, Jia, H, Joshi, A, Jurman, G, Kaczkowski, B, Kai, C, Kaida, K, Kaiho, A, Kajiyama, K, Kanamori Katayama, M, Kasianov, As, Kasukawa, T, Katayama, S, Kato, S, Kawaguchi, S, Kawamoto, H, Kawamura, Yi, Kawashima, T, Kempfle, Js, Kenna, Tj, Kere, J, Khachigian, Lm, Kitamura, T, Klinken, Sp, Knox, Aj, Kojima, M, Kojima, S, Kondo, N, Koseki, H, Koyasu, S, Krampitz, S, Kubosaki, A, Kwon, At, Laros, Jf, Lee, W, Lennartsson, A, Li, K, Lilje, B, Lipovich, L, Mackay Sim, A, Manabe, R, Mar, Jc, Marchand, B, Mathelier, A, Mejhert, N, Meynert, A, Mizuno, Y, Morais, Da, Morimoto, M, Moro, K, Motakis, E, Motohashi, H, Mummery, Cl, Murata, M, Nakachi, Y, Nakahara, F, Nakamura, T, Nakamura, Y, Nakazato, K, van Nimwegen, E, Ninomiya, N, Nishiyori, H, Noma, S, Nozaki, T, Ogishima, S, Ohmiya, H, Ohno, H, Ohshima, M, Okada Hatakeyama, M, Okazaki, Y, Orlando, V, Ovchinnikov, Da, Pain, A, Passier, R, Patrikakis, M, Persson, H, Piazza, S, Prendergast, Jg, Rackham, Oj, Ramilowski, Ja, Rashid, M, Ravasi, T, Rizzu, P, Roncador, M, Roy, S, Rye, Mb, Saijyo, E, Sajantila, A, Saka, A, Sakai, M, Sato, H, Satoh, H, Savvi, S, Saxena, A, Schneider, C, Schultes, Ea, Schulze Tanzil GG, Schwegmann, A, Sengstag, T, Sheng, G, Shimoji, H, Shimoni, Y, Shin, Jw, Simon, C, Sugiyama, D, Sugiyama, T, Suzuki, M, Swoboda, Rk, 't Hoen PA, Tagami, M, Takahashi, N, Takai, J, Tanaka, H, Tatsukawa, H, Tatum, Z, Thompson, M, Toyoda, H, Toyoda, T, Valen, E, van de Wetering, M, van den Berg LM, Verardo, R, Vijayan, D, Vorontsov, Ie, Wasserman, Ww, Watanabe, S, Wells, Ca, Winteringham, Ln, Wolvetang, E, Wood, Ej, Yamaguchi, Y, Yamamoto, M, Yoneda, M, Yonekura, Y, Yoshida, S, Zabierowski, Se, Zhang, Pg, Zhao, X, Zucchelli, S, Summers, Km, Suzuki, H, Daub, Co, Kawai, J, Heutink, P, Hide, W, Freeman, Tc, Lenhard, B, Bajic, Vb, Taylor, Ms, Makeev, Vj, Sandelin, A, Hume, Da, Hayashizaki, Y.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(14), 5289-5294. National Academy of Sciences
University of Western Australia
Proceedings of the National Academy of Sciences, 111(14), 5289-5294
Proceedings of the National Academy of Sciences of the United States of America, 111(14), 5289-94. National Academy of Sciences

Naturally occurring regulatory T (Treg) cells, which specifically express the transcription factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-tolerance and homeostasis. By transcriptional start site cluster analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36c21559e09eded6c21af9387e9344a
https://doi.org/10.1073/pnas.1312717110

FANTOM5 CAGE profiles of human and mouse samples.

Autor: Noguchi S; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan., Arakawa T; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Fukuda S; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Furuno M; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Hasegawa A; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Hori F; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Ishikawa-Kato S; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Kaida K; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Kaiho A; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Kanamori-Katayama M; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Kawashima T; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Kojima M; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Kubosaki A; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Manabe RI; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Murata M; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Nagao-Sato S; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Nakazato K; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Ninomiya N; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Nishiyori-Sueki H; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Noma S; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Saijyo E; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Saka A; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Sakai M; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Simon C; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Suzuki N; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Tagami M; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Watanabe S; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Yoshida S; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Arner P; Department of Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.; Karolinska University Hospital, Center for Metabolism and Endocrinology, 141 86, Stockholm, Sweden., Axton RA; Scottish Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK., Babina M; Department of Dermatology and Allergy, Charite University Medicine Berlin, Charitéplatz 1, 10117 Berlin, German., Baillie JK; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK., Barnett TC; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia., Beckhouse AG; Bio-Rad Laboratories Pty Ltd, Hercules, California 94547, USA., Blumenthal A; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102 Australia., Bodega B; IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy., Bonetti A; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Briggs J; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia., Brombacher F; Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Anzio Road, Observatory 7925, Cape Town, South Africa., Carlisle AJ; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK., Clevers HC; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.; University Medical Centre Utrecht, Postbus 85500, 3508 GA Utrecht, The Netherlands., Davis CA; Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11797, USA., Detmar M; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich, Switzerland., Dohi T; Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan., Edge ASB; Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA., Edinger M; Department of Internal Medicine III, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany.; RCI Regensburg Centre for Interventional Immunology, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany., Ehrlund A; Department of Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.; Karolinska University Hospital, Center for Metabolism and Endocrinology, 141 86, Stockholm, Sweden., Ekwall K; Department of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7-9, SE-141 83 Huddinge, Sweden., Endoh M; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Enomoto H; Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Chuou-ku, Kobe 650-0047, Japan., Eslami A; Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan., Fagiolini M; F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Fairbairn L; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK., Farach-Carson MC; The University of Texas Health Science Center at Houston, Houston, TX 77251-1892, USA., Faulkner GJ; Cancer Biology Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia., Ferrai C; Berlin Institute for Medical Systems Biology, Max Delbrueck Center, Robert Roessle Str.10, 13125 Berlin, Germany., Fisher ME; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK., Forrester LM; Scottish Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK., Fujita R; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan., Furusawa JI; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Geijtenbeek TB; Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Gingeras T; Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11797, USA., Goldowitz D; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Guhl S; Department of Dermatology and Allergy, Charite University Medicine Berlin, Charitéplatz 1, 10117 Berlin, German., Guler R; Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Anzio Road, Observatory 7925, Cape Town, South Africa., Gustincich S; Neuroscience, SISSA, Via Bonomea 265, 34136 Trieste, Italy.; Department of Neuroscience and Brian Technologies, Italian Istitute of Technology, Via Morego 30, Genova, Italy., Ha TJ; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Hamaguchi M; Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Hara M; RIKEN Center for Life Science Technologies, Wako, Saitama 351-0198, Japan., Hasegawa Y; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Herlyn M; Melanoma Research Center, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA., Heutink P; German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Otfried Müller Straße 23, 72076 Tübingen, Germany., Hitchens KJ; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia., Hume DA; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK., Ikawa T; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Ishizu Y; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Kai C; Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.; International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., Kawamoto H; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Kawamura YI; Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan., Kempfle JS; Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA., Kenna TJ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia., Kere J; Department of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7-9, SE-141 83 Huddinge, Sweden.; Department of Genetics and Molecular Medicine, King's College London, Guy's St Thomas Street, London, UK., Khachigian LM; Centre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia.; Vascular Biology and Translational Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia., Kitamura T; Division of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., Klein S; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich, Switzerland., Klinken SP; Harry Perkins Institute of Medical Research, Perth, WA 6009, Australia., Knox AJ; Respiratory Medicine, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK., Kojima S; RIKEN Center for Life Science Technologies, Wako, Saitama 351-0198, Japan., Koseki H; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Koyasu S; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Lee W; Dermatology, School of Medicine Kyungpook National University, Jung-gu, Daegu 41944, Korea., Lennartsson A; Department of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7-9, SE-141 83 Huddinge, Sweden., Mackay-Sim A; Griffith University, Brisbane, Queensland 4111, Australia., Mejhert N; Department of Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.; Karolinska University Hospital, Center for Metabolism and Endocrinology, 141 86, Stockholm, Sweden., Mizuno Y; Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan., Morikawa H; Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Morimoto M; Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Chuou-ku, Kobe 650-0047, Japan., Moro K; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Morris KJ; Berlin Institute for Medical Systems Biology, Max Delbrueck Center, Robert Roessle Str.10, 13125 Berlin, Germany., Motohashi H; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan., Mummery CL; Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden, The Netherlands., Nakachi Y; Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.; Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan., Nakahara F; Division of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., Nakamura T; Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., Nakamura Y; Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan., Nozaki T; Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan., Ogishima S; Department of Bioclinical Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi 980-8573, Japan., Ohkura N; Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Ohno H; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Ohshima M; Department of Biochemistry, Ohu University School of Pharmaceutical Sciences, Koriyama, Fukushima 963-8611 Japan., Okada-Hatakeyama M; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Insitute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan., Okazaki Y; Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.; Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan., Orlando V; IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy.; Environmental Epigenetics Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia., Ovchinnikov DA; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia., Passier R; Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden, The Netherlands., Patrikakis M; Centre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia., Pombo A; Berlin Institute for Medical Systems Biology, Max Delbrueck Center, Robert Roessle Str.10, 13125 Berlin, Germany., Pradhan-Bhatt S; University of Delaware, Newark, DE 19716 USA., Qin XY; RIKEN Center for Life Science Technologies, Wako, Saitama 351-0198, Japan., Rehli M; Department of Internal Medicine III, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany.; RCI Regensburg Centre for Interventional Immunology, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany., Rizzu P; German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Otfried Müller Straße 23, 72076 Tübingen, Germany., Roy S; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Sajantila A; Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Kytosuontie 11, 003000 Helsinki, Finland., Sakaguchi S; Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Sato H; Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., Satoh H; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan., Savvi S; Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Anzio Road, Observatory 7925, Cape Town, South Africa., Saxena A; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Schmidl C; Department of Internal Medicine III, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany., Schneider C; Laboratorio Nazionale CIB, Padriciano, 99 34149, Trieste, Italy., Schulze-Tanzil GG; Department of Orthopedic, Trauma and Reconstructive Surgery, Charite Universitatsmedizin Berlin, Charitéplatz 1, 10117 Berlin, German., Schwegmann A; Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Anzio Road, Observatory 7925, Cape Town, South Africa., Sheng G; International Research Center for Medical Sciences (IRCMS), Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan., Shin JW; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Sugiyama D; Department of Clinical Study, Center for Advanced Medical Innovation, Kyushu University, Higashi-Ku, Fukuoka 812-8582, Japan., Sugiyama T; Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., Summers KM; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK., Takahashi N; RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan., Takai J; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan., Tanaka H; Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan., Tatsukawa H; Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan., Tomoiu A; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK., Toyoda H; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan., van de Wetering M; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands., van den Berg LM; Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Verardo R; Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie (LNCIB), Padriciano 99, 34149 Trieste, Italy., Vijayan D; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Wells CA; Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, MDHS, University of Melbourne, Melbourne, VIC 3010, Australia., Winteringham LN; Harry Perkins Institute of Medical Research, Perth, WA 6009, Australia., Wolvetang E; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia., Yamaguchi Y; Department of Biochemistry, Nihon University School of Dentistry, Chiyoda-ku, Tokyo 101-8310, Japan., Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan., Yanagi-Mizuochi C; Center for Clinical and Translational Reseach, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan., Yoneda M; Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., Yonekura Y; Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Chuou-ku, Kobe 650-0047, Japan., Zhang PG; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Zucchelli S; 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