Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Patrik Wolle"'
Autor:
Patrik Wolle, Josef M. Penninger, Daniel Rauh, Shane J. F. Cronin, Jonas Lategahn, Matthias Baumann, Julia Hardick, Julian Engel
Publikováno v:
Journal of Medicinal Chemistry. 62:2843-2848
The protein kinase MKK7 is linked to neuronal development and the onset of cancer. The field, however, lacks high-quality functional probes that would allow for the dissection of its detailed functions. Against this background, we describe an effecti
Publikováno v:
ACS Chemical Biology. 15:296-297
Autor:
Patrik Wolle, Julian Engel, Steven Smith, Lisa Goebel, Elisabeth Hennes, Jonas Lategahn, Daniel Rauh
Publikováno v:
Journal of medicinal chemistry. 62(11)
Pyrazolopyrimidines are well-established as covalent inhibitors of protein kinases such as the epidermal growth factor receptor or Bruton's tyrosine kinase, and we recently described their potential in targeting mitogen-activated protein kinase kinas
Publikováno v:
ChemMedChem. 13(19)
The identification of compounds for dissecting biological functions and the development of novel drug molecules are central tasks that often require screening campaigns. However, the required architecture is cost- and time-intensive. Herein we descri
Publikováno v:
ACS chemical biology. 13(3)
The examination of three-dimensional structural models in scientific publications allows the reader to validate or invalidate conclusions drawn by the authors. However, either due to a (temporary) lack of access to proper visualization software or a
Autor:
Dennis Plenker, Trang Thi Phuong Phan, Jeffrey R. Simard, Daniel Rauh, Hoang Duc Nguyen, Stefan Baumeister, Zhizhou Fang, Patrik Wolle
Publikováno v:
ACS Chemical Biology. 10:279-288
In addition to the catalytically active kinase domain, most kinases feature regulatory domains that govern their activity. Modulating and interfering with these interdomain interactions presents a major opportunity for understanding biological system