Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patrik Onnerfjord"'
Autor:
Rocío Paz-González, Aleksandra Turkiewicz, Neserin Ali, Cristina Ruiz-Romero, Francisco J. Blanco, Martin Englund, Patrik Önnerfjord
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 4, Pp 100417- (2023)
Objective: To gain new insight into the molecular changes of the meniscus by comparing the proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis (OA). Method: We obtained tissue plugs from lateral and medial menisc
Externí odkaz:
https://doaj.org/article/d2dbd4769bac418ca4969291b2e620a6
Autor:
Lloyd Tanner, Jesper Bergwik, Ravi K. V. Bhongir, Manoj Puthia, Pernilla Lång, Mohamad N. Ali, Charlotte Welinder, Patrik Önnerfjord, Jonas S. Erjefält, Lena Palmberg, Göran Andersson, Arne Egesten
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionDuring airway infection, upregulation of proinflammatory cytokines and subsequent immune cell recruitment is essential to mitigate bacterial infection. Conversely, during prolonged and non-resolving airway inflammation, neutrophils contri
Externí odkaz:
https://doaj.org/article/2ee8d6efa52445b69b6dfca1ea9deb16
Autor:
Solveig Skovlund Groen, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Christian S. Thudium, Morten A. Karsdal, Simon Francis Thomsen, Sven Lindemann, Daniela Werkmann, Joseph Blair, Line Mærsk Staunstrup, Patrik Önnerfjord, Lars Arendt-Nielsen, Signe Holm Nielsen
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100207- (2021)
Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and robust assay measuring type II collagen degradation (T2CM) and dis
Externí odkaz:
https://doaj.org/article/dbead7b88abd48ba819c5601d42f0785
Autor:
Rebecca Mae Black, Yang Wang, André Struglics, Pilar Lorenzo, Susan Chubinskaya, Alan J. Grodzinsky, Patrik Önnerfjord
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100191- (2021)
Objectives: In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) to distinguish clusters of proteins based on their kinetics of release from cartilage and examined the
Externí odkaz:
https://doaj.org/article/093224d3d1db4fb5b53c424d4fb42dd0
Autor:
Heide Boeth, Peter C. Raffalt, Aoife MacMahon, A. Robin Poole, Felix Eckstein, Wolfgang Wirth, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N. Duda
Publikováno v:
Journal of Experimental Orthopaedics, Vol 6, Iss 1, Pp 1-10 (2019)
Abstract Background An early detection of Osteoarthritis is urgently needed and still not possible until today. The aim of the study was to assess whether molecular biomarkers of cartilage turnover are associated with longitudinal change in knee cart
Externí odkaz:
https://doaj.org/article/d9a185abdbeb43b897822c222321da6e
Autor:
Anna Cronström, May Arna Risberg, Martin Englund, Carl Johan Tiderius, Patrik Önnerfjord, André Struglics, Jonas Svensson, Pernilla Peterson, Sven Månsson, Eva Ageberg
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100102- (2020)
Summary: Introduction: Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be
Externí odkaz:
https://doaj.org/article/c185a94a60644679b4235e56ec82a23a
Autor:
Rebecca Mae Black, Yang Wang, André Struglics, Pilar Lorenzo, Viveka Tillgren, Martin Rydén, Alan J. Grodzinsky, Patrik Önnerfjord
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100099- (2020)
Summary: Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocortic
Externí odkaz:
https://doaj.org/article/15cb81ecb47d4e6cbfdb7673cf7b5853
Autor:
Maojia Xu, Eva-Lena Stattin, Georgina Shaw, Dick Heinegård, Gareth Sullivan, Ian Wilmut, Alan Colman, Patrik Önnerfjord, Areej Khabut, Anders Aspberg, Peter Dockery, Timothy Hardingham, Mary Murphy, Frank Barry
Publikováno v:
Stem Cells Translational Medicine, Vol 5, Iss 9, Pp 1171-1181 (2016)
Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is associated with a heterozygous mu
Externí odkaz:
https://doaj.org/article/f921e2842d114179b88d89856f7577c0
Autor:
Lovisa Hessle, Gunhild A Stordalen, Christina Wenglén, Christiane Petzold, Elizabeth K Tanner, Sverre-Henning Brorson, Espen S Baekkevold, Patrik Önnerfjord, Finn P Reinholt, Dick Heinegård
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63080 (2014)
Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their α2β1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell. Ad
Externí odkaz:
https://doaj.org/article/b9105d4a8e204ba0b64b08144ae7442c
Autor:
Lotta Gustafsson, Sonja Aits, Patrik Onnerfjord, Maria Trulsson, Petter Storm, Catharina Svanborg
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5229 (2009)
Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome res
Externí odkaz:
https://doaj.org/article/b30703d030d24abe9068ad95d991ec2b