Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Patrik Engström"'
Autor:
Gina M. Borgo, Thomas P. Burke, Cuong J. Tran, Nicholas T. N. Lo, Patrik Engström, Matthew D. Welch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Pathogenic Rickettsia species are arthropod-borne, obligate intracellular bacteria that invade host cells, replicate in the cell cytosol, and spread from cell to cell. Here, Borgo et al. identify a Rickettsia phospholipase enzyme that is important fo
Externí odkaz:
https://doaj.org/article/76fc7169ff2a4a5fa9121ffd75dec244
Autor:
Thomas P Burke, Patrik Engström, Cuong J Tran, Ingeborg M Langohr, Dustin R Glasner, Diego A Espinosa, Eva Harris, Matthew D Welch
Publikováno v:
eLife, Vol 10 (2021)
Arthropod-borne rickettsial pathogens cause mild and severe human disease worldwide. The tick-borne pathogen Rickettsia parkeri elicits skin lesions (eschars) and disseminated disease in humans; however, inbred mice are generally resistant to infecti
Externí odkaz:
https://doaj.org/article/07eddd4f03e24d1f84e96e5ba2c2bb6f
Autor:
Patrik Engström, K. Syam Krishnan, Bidong D. Ngyuen, Erik Chorell, Johan Normark, Jim Silver, Robert J. Bastidas, Matthew D. Welch, Scott J. Hultgren, Hans Wolf-Watz, Raphael H. Valdivia, Fredrik Almqvist, Sven Bergström
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed to be associated with the
Externí odkaz:
https://doaj.org/article/00303facf7d845949d710878fb025781
Autor:
Johan Normark, Maria Nelson, Patrik Engström, Marie Andersson, Rafael Björk, Thomas Moritz, Anna Fahlgren, Sven Bergström
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103295 (2014)
In the Plasmodium infected host, a balance between pro- and anti-inflammatory responses is required to clear the parasites without inducing major host pathology. Clinical reports suggest that bacterial infection in conjunction with malaria aggravates
Externí odkaz:
https://doaj.org/article/fe2008a786bc46c2a789d460baf54c65
Autor:
Matthew D. Welch, Dustin R. Glasner, Diego A. Espinosa, Cuong J. Tran, Ingeborg M. Langohr, Eva Harris, Thomas P. Burke, Patrik Engström
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Arthropod-borne rickettsial pathogens cause mild and severe human disease worldwide. The tick-borne pathogen Rickettsia parkeri elicits skin lesions (eschars) and disseminated disease in humans; however, inbred mice are generally resistant to infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9024e19f21fd6374ade7ef3b69233e0f
https://escholarship.org/uc/item/8sw4738b
https://escholarship.org/uc/item/8sw4738b
Publikováno v:
Science advances, vol 7, iss 26
Science Advances
Science Advances
Lysine methylation camouflages a bacterial pathogen from the host ubiquitin attack.
Many intracellular pathogens avoid detection by their host cells. However, it remains unknown how they avoid being tagged by ubiquitin, an initial step leading t
Many intracellular pathogens avoid detection by their host cells. However, it remains unknown how they avoid being tagged by ubiquitin, an initial step leading t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe800a80c360996448fd1f25fd68ebea
https://doi.org/10.1126/sciadv.abg2517
https://doi.org/10.1126/sciadv.abg2517
Autor:
Matthew D. Welch, Patrik Engström, Michael Rape, Kevin G. Mark, Nadia Ingabire, Anthony T. Iavarone, Guillaume Golovkine, Gabriel Mitchell, Thomas P. Burke, Jeffery S. Cox
Publikováno v:
Nature microbiology
Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step of polyubiquitin-coat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009ca3088ba4e8da15f9d7c9a1656690
https://doi.org/10.1038/s41564-019-0583-6
https://doi.org/10.1038/s41564-019-0583-6
Autor:
Thomas P. Burke, Dustin R. Glasner, Eva Harris, Matthew D. Welch, Diego A. Espinosa, Ingeborg M. Langohr, Cuong J. Tran, Patrik Engström
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eed256b6748147592683d745ff5fe32
https://doi.org/10.7554/elife.67029.sa2
https://doi.org/10.7554/elife.67029.sa2
Many intracellular pathogens avoid detection by their host cells. However, it remains unknown how they avoid being tagged by ubiquitin, an initial step leading to anti-microbial autophagy. Here, we show that the intracellular bacterial pathogen Ricke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0dd65b049be2ad55572688849f9ea1
https://doi.org/10.1101/2020.11.20.392290
https://doi.org/10.1101/2020.11.20.392290