A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)

Autor: Sólrún Melkorka Maggadóttir, Gunnar Kvalheim, Patrik Wernhoff, Stein Sæbøe-Larssen, Mona-Elisabeth Revheim, Dag Josefsen, Sébastien Wälchli, Åslaug Helland, Else Marit Inderberg

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundAdoptive cellular therapy (ACT) with genetically modified T cells aims to redirect T cells against resistant cancers through introduction of a T cell receptor (TCR). The Radium-4 TCR was isolated from a responding patient in a cancer vaccin

Externí odkaz: https://doaj.org/article/60e4d16bba4146cda688a9bb43b7ba8b

Soluble AXL as a marker of disease progression and survival in melanoma.

Autor: Karine Flem-Karlsen, Marta Nyakas, Inger Nina Farstad, Erin McFadden, Patrik Wernhoff, Kari Dolven Jacobsen, Vivi Ann Flørenes, Gunhild Mari Mælandsmo

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0227187 (2020)

Receptor tyrosine kinase AXL is a one-pass transmembrane protein upregulated in cancers and associated with lower survival and therapy resistance. AXL can be cleaved by the A Disintegrin and Metalloproteinases (ADAM)10 and ADAM17, yielding a soluble

Externí odkaz: https://doaj.org/article/6d25b75e3c324aac915021869a7e4931

Genetic Characterization in High-Risk Individuals from a Low-Resource City of Peru

Autor: Elizabeth Zavaleta, Nelly Solis, Maria Isabel Palacios, Liz Elva Zevallos-Escobar, Edison Vasquez Corales, Juan Carlos Bazo-Alvarez, Constantino Dominguez-Barrera, Anthony Campos, Patrik Wernhoff, Per Olaf Ekstrøm, Pål Møller, Tina Visnovska, Eivind Hovig, Janina Balazar-Palacios, Karin Alvarez-Valenzuela, Sigve Nakken, Mev Dominguez-Valentin

Publikováno v: Cancers; Volume 14; Issue 22; Pages: 5603

Background: Genetic testing for hereditary cancers is inconsistently applied within the healthcare systems in Latin America. In Peru, the prevalence and spectrum of cancer-predisposing germline variants is thus poorly characterized. Purpose: To deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7371b3ed7d16a83a334edcb1ed7bec22
https://pubmed.ncbi.nlm.nih.gov/36428697

From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America

Autor: Maria Nirvana Formiga, Joseph A. Pinto, Caroline U. Sa, Celia Aparecida Marques Pimenta, Julio Sanchez del Monte, Carlos A. Vaccaro, Mabel Bohorquez, Patricia Esperon, Florencia Spirandelli, Patricia Ashton-Prolla, Carmelo Caballero, Gutiérrez Angulo Melva, Maria del Carmen Castro-Mujica, Edite P. Oliveira, Norma Teresa Rossi, Sergio Chialina, Ivana Nascimento, Claudia Barletta-Carrillo, Larissa Souza Mario Bueno, Geth, Yesilda Balavarca, Jorge Padron, Edenir Inêz Palmero, Francisco López-Köstner, Sabrina Daniela da Silva, Nora Manoukian Forones, Juan Carlos Bazo-Alvarez, Florencia Neffa, Alcides Recalde Cañete, Mariela Torres Loarte, Pål Møller, Constantino Dominguez-Barrera, Mev Dominguez-Valentin, Pablo Kalfayan, John-Paul Plazzer, Jose Buleje, Kiyoko Abe-Sandes, Florencia C. Cardoso, Dirce Maria Carraro, Eivind Hovig, Patrik Wernhoff, Rodrigo Santa Cruz Guindalini, María Laura Gonzalez, Paola Montenegro Beltran, Marina Antelo, Angela R. Solano, Henrique de Campos Reis Galvão, Sonia Tereza dos Santos Nogueira, Samuel Aguiar Junior, Carlos Sarroca, Alberto Ignacio Herrando, Leonardo S. Lino-Silva, Carlos Mario Muñetón Peña, Tamara Alejandra Piñero, Erika Maria Monteiro Santos, Benedito Mauro Rossi, Mariano Golubicki, Yasser Sullcahuaman, Enrique Spirandelli, Geiner Jimenez, Karin Alvarez, Giovana Tardin Torrezan, Daniel Cisterna, Yenni Rodriguez, Richard Quispe, Ricardo Fujita, Claudia Martin, Della Valle Adriana, Renata Gondim Meira Velame de Azevedo, Lina Nuñez

Publikováno v: Repositorio Académico USMP
Universidad San Martín de Porres-USMP
USMP-Institucional
Universidad de San Martín de Porres
instacron:USMP
International Journal of Cancer
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and Argentina. We provide a global snapshot of the CRC patterns, how screening is performed, and compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877aeca091c95233becfe121cbeb957b
https://doi.org/10.1002/ijc.31920

MX2 is a novel regulator of cell cycle in melanoma cells

Autor: Joanna Pozniak, Marina Juraleviciute, Juliette Randerson-Moor, Meenhard Herlyn, Jérémie Nsengimana, Geir Frode Øy, D T Bishop, Julia Newton-Bishop, Mark Harland, Vivi Ann Flørenes, Ana Slipicevic, Assia Bassarova, Patrik Wernhoff, Gunhild Trøen

Publikováno v: Pigment Cell Melanoma Res
Pigment Cell & Melanoma Research

MX2 protein is a dynamin-like GTPase2 that has recently been identified as an interferon-induced restriction factor of HIV-1 and other primate lentiviruses. A single nucleotide polymorphism (SNP), rs45430, in an intron of the MX2 gene, was previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcbec8bc70cba2a17b7fde7fbbe0c96
https://europepmc.org/articles/PMC7180100/