Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Patrik, Schadzek"'
Publikováno v:
FEBS Open Bio, Vol 9, Iss 5, Pp 840-850 (2019)
Connexins (Cx) are proteins that form cell‐to‐cell gap junction channels. A mutation at position 188 in the second extracellular loop (E2) domain of hCx46 has been linked to an autosomal dominant zonular pulverulent cataract. As it is dominantly
Externí odkaz:
https://doaj.org/article/1ee0e2e53bac440599e41cc4f4c1ba70
Autor:
Anne Dierks, Corinne Vanucci-Bacqué, Anne-Marie Schäfer, Tina Lehrich, Frederike Ruhe, Patrik Schadzek, Florence Bedos-Belval, Anaclet Ngezahayo
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1173 (2022)
Inflammation mediators enhance the activity of connexin (Cx) hemichannels, especially in the epithelial and endothelial tissues. As potential release routes for injury signals, such as (oligo)nucleotides, Cx hemichannels may contribute to long-lastin
Externí odkaz:
https://doaj.org/article/49d3bfd2ecb743cfb588b1152c28c6b8
Autor:
Patrik Schadzek, Barbara Schlingmann, Frank Schaarschmidt, Julia Lindner, Michael Koval, Alexander Heisterkamp, Anaclet Ngezahayo, Matthias Preller
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 93-99 (2016)
The structure of hCx26 derived from the X-ray analysis was used to generate a homology model for hCx46. Interacting connexin molecules were used as starting model for the molecular dynamics (MD) simulation using NAMD and allowed us to predict the dyn
Externí odkaz:
https://doaj.org/article/66edeba9df764ebe915acb7fc322b467
Autor:
Tatjana P Harting, Mandy Stubbendorff, Susanne C Hammer, Patrik Schadzek, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178744 (2017)
Targeting mitochondrial energy metabolism is a novel approach in cancer research and can be traced back to the description of the Warburg effect. Dichloroacetate, a controversially discussed subject of many studies in cancer research, is a pyruvate d
Externí odkaz:
https://doaj.org/article/d2758f3f002e47aeb53103d9643afc90
Autor:
Sabrina Zippel, Nadine Dilger, Chandralekha Chatterjee, Annamarija Raic, Gerald Brenner-Weiß, Patrik Schadzek, Bastian E Rapp, Cornelia Lee-Thedieck
Publikováno v:
Biofabrication, 14 (3), Art.Nr. 035011
Leukemia patients undergo chemotherapy to combat the leukemic cells (LCs) in the bone marrow. During therapy not only the LCs, but also the blood-producing hematopoietic stem and progenitor cells (HSPCs) may be destroyed. Chemotherapeutics targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b421ee12436800ce24ff3763c8fd2dd
https://publikationen.bibliothek.kit.edu/1000148794/149034463
https://publikationen.bibliothek.kit.edu/1000148794/149034463
Autor:
Sabrina, Zippel, Nadine, Dilger, Chandralekha, Chatterjee, Annamarija, Raic, Gerald, Brenner-Weiß, Patrik, Schadzek, Bastian E, Rapp, Cornelia, Lee-Thedieck
Publikováno v:
Biofabrication. 14(3)
Leukemia patients undergo chemotherapy to combat the leukemic cells (LCs) in the bone marrow. During therapy not only the LCs, but also the blood-producing hematopoietic stem and progenitor cells (HSPCs) may be destroyed. Chemotherapeutics targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae60c148186f9afa39ae8b75f4a24ef4
https://pubmed.ncbi.nlm.nih.gov/35472717
https://pubmed.ncbi.nlm.nih.gov/35472717
Autor:
Laura Burmeister, Virginia Seiffart, Sandra Laggies, Beatrice Oelze, Anika Hamm, Andrea Hoffmann, Kirsten Elger, Patrik Schadzek, Gerhard Gross
Publikováno v:
Molecular and Cellular Biochemistry
As a response to pro-inflammatory signals mesenchymal stem cells (MSCs) secrete agents and factors leading to lymphocyte recruitment, counteracting inflammation, and stimulating immunosuppression. On a molecular level, the signalling mediator TGF-β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fcf910dee1df01860ec9ee8b6e1913
https://pubmed.ncbi.nlm.nih.gov/34052945
https://pubmed.ncbi.nlm.nih.gov/34052945
Autor:
Siegfried Wagner, Patrik Schadzek, Saskia Willenbrock, Hugo Murua Escobar, Tatjana P. Harting, Anaclet Ngezahayo, Ingo Nolte, Mandy Stubbendorff
Publikováno v:
International Journal of Oncology. 49:2341-2350
The Warburg effect describes the ability of cancer cells to produce energy via aerobic glycolysis instead of oxidative phosphorylation of pyruvate. This deviation in mitochondrial metabolism inhibits apoptosis, allowing increased proliferation under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c68103b06970a24665fb20ee416cc3a
https://doi.org/10.3892/ijo.2016.3720
https://doi.org/10.3892/ijo.2016.3720
Autor:
Julia Lindner, Michael Koval, Frank Schaarschmidt, Alexander Heisterkamp, Patrik Schadzek, Matthias Preller, Anaclet Ngezahayo, Barbara Schlingmann
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:57-66
The mutation N188T in human connexin46 (hCx46) correlates with a congenital nuclear pulverulent cataract. This mutation is in the second extracellular loop, a domain involved in docking of gap junction hemichannels. To analyze the functional conseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdf05c408cc66e47d3c13c8ee32971f
https://doi.org/10.1016/j.bbamem.2015.10.001
https://doi.org/10.1016/j.bbamem.2015.10.001
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5177, p 5177 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Musculoskeletal dysfunctions are highly prevalent due to increasing life expectancy. Consequently, novel solutions to optimize treatment of patients are required. The current major research focus is to develop innovative concepts for single tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561f249b8103ae9734e16c0d82da8d73
https://doi.org/10.3390/ijms21155177
https://doi.org/10.3390/ijms21155177