Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Patrik, Holm"'
Autor:
Patrik Holm, Linda Beckman
Objectives The aim of this study was to investigate differences in academic achievement between two groups of students who were taught the same course online within the nursing program but through two different teaching strategies and to examine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3593ea3879932e9406068b56c77f60e
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-88683
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-88683
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Autor:
Victor J Nesatyy, Anton N. Kozhinov, Pasi Virta, Konstantin O. Nagornov, Natalia Gasilova, Yury O. Tsybin, Patrik Holm, Laure Menin
Publikováno v:
Analytical chemistry. 93(38)
The therapeutic efficacy and pharmacokinetics of antibody-drug conjugates (ADCs) in general, and antibody-oligonucleotide conjugates (AOCs) in particular, depend on the drug-to-antibody ratio (DAR) distribution and average value. The DAR is considere
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Autor:
Zsolt Némethy, Balázs Lendvai, Balázs Krámos, Katalin Dudás Molnár, Ottilia Balázs, Anita Horváth, Áron Szigetvári, György Lévay, János Kóti, János Éles, Istvan Vago, István Ledneczki, András Visegrády, Mónika Vastag, Marta Than, Pál Tapolcsányi, Diána Kostyalik, Sándor Mahó, Sándor Kolok, Patrik Holm, László Fodor, István Greiner, László Kiss
Publikováno v:
European Journal of Medicinal Chemistry. 222:113560
HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During the hit expansion, several derivatives, such as 4, 11, 17 demonstrated not only high in vi
Autor:
Balázs Lendvai, Anna E. Káncz, Pál Tapolcsányi, Zoltán Béni, János Kóti, Marta Than, Éva Bozó, János Éles, István Greiner, Judit Laszy, Zsolt Némethy, Sándor Mahó, András Visegrády, Márton Vass, Gyula Bugovits, György Lévay, István Ledneczki, Anikó Pocsai, Balázs Krámos, Ágota Szájli, Mónika Vastag, Patrik Holm, Sándor Kolok, Eszter Gábor, Ottilia Balázs, Anita Horváth, József Nagy
Publikováno v:
European Journal of Medicinal Chemistry. 214:113189
The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around the reference molecule (A-867744). First, substantial efforts were carried out to ass
Autor:
Olof Solin, Merja Haaparanta-Solin, Kjell Någren, Eliisa Löyttyniemi, Tove J. Grönroos, Patrik Holm, Jukka Sallinen, Semi Helin, Päivi Marjamäki, Mika Scheinin, Eveliina Arponen
Publikováno v:
Journal of Nuclear Medicine. 55:1171-1177
We report the development of a PET tracer for α2C adrenoceptor imaging and its preliminary preclinical evaluation. α2C adrenoceptors in the human brain may be involved in various neuropsychiatric disorders, such as depression, schizophrenia, and ne
Publikováno v:
Journal of Immunological Methods. 364:65-76
Single-chain variable fragments (scFvs) are small monovalent recombinant antibody fragments that retain the specificity of their parent immunoglobulins. ScFvs are excellent building blocks for new and improved immunodiagnostic and therapeutic protein
Publikováno v:
mAbs. 2:662-669
Recombinant antibodies may be engineered to obtain improved functional properties. Functional mapping of the residues in the binding surfaces is of importance for predicting alterations needed to yield the desired properties. In this investigation, 1
Publikováno v:
Molecular Immunology. 44:1075-1084
The anti-cytokeratin (CK) 8 monoclonal antibody (mab) TS1 has been shown to efficiently bind to CK8 expressed in carcinomas in vivo. The anti-idiotypic antibody of TS1, alphaTS1, can be used to regulate the tumor:non-tumor ratio of TS1 by clearing no