Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Patrick. L. Iversen"'
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-25 (2024)
Abstract Background Xenobiotic exposures can extensively influence the expression and alternative splicing of drug-metabolizing enzymes, including cytochromes P450 (CYPs), though their transcriptome-wide impact on splicing remains underexplored. This
Externí odkaz:
https://doaj.org/article/688452e273ea41e5b9ce02bbef330ca8
Autor:
Patrick L. Iversen, Nicholas Kipshidze, Nodar Kipshidze, George Dangas, Eduardo Ramacciotti, Zurab Kakabadze, Jawed Fareed
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
The burden of atherosclerotic cardiovascular disease contributes to a large proportion of morbidity and mortality, globally. Vaccination against atherosclerosis has been proposed for over 20 years targeting different mediators of atherothrombosis; ho
Externí odkaz:
https://doaj.org/article/35eb871ae7bc4b8baeffedcd9978a4ff
Autor:
Travis K. Warren, Christopher D. Kane, Jay Wells, Kelly S. Stuthman, Sean A. Van Tongeren, Nicole L. Garza, Ginger Donnelly, Jesse Steffens, Laura Gomba, Jessica M. Weidner, Sarah Norris, Xiankun Zeng, Roy Bannister, Tomas Cihlar, Sina Bavari, Danielle P. Porter, Patrick L. Iversen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory l
Externí odkaz:
https://doaj.org/article/8b24a8ac056941f5a1d728fbbaf1db9c
Autor:
Kevin A. Lidberg, Andrew J. Annalora, Marija Jozic, Daniel J. Elson, Lu Wang, Theo K. Bammler, Susanne Ramm, Maria Beatriz Monteiro, Jonathan Himmelfarb, Craig B. Marcus, Patrick L. Iversen, Edward J. Kelly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expressi
Externí odkaz:
https://doaj.org/article/a3c201a0a7084bb899171d4e7331ae73
Autor:
Janice A. Williams, Simon Y. Long, Xiankun Zeng, Kathleen Kuehl, April M. Babka, Neil M. Davis, Jun Liu, John C. Trefry, Sharon Daye, Paul R. Facemire, Patrick L. Iversen, Sina Bavari, Margaret L. Pitt, Farooq Nasar
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 5 (2022)
Eastern equine encephalitis virus (EEEV) is mosquito-borne virus that produces fatal encephalitis in humans. We recently conducted a first of its kind study to investigate EEEV clinical disease course following aerosol challenge in a cynomolgus macaq
Externí odkaz:
https://doaj.org/article/4f5acd08ce834e0ab487c8ee28a4c1e2
Autor:
Mark R. Hickman, David L. Saunders, Catherine A. Bigger, Christopher D. Kane, Patrick L. Iversen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 3 (2022)
The Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND) began development of a broad-spectrum antiviral countermeasure against deliberate use of high-consequence viral hemorrhagic fevers (VHFs) in 2
Externí odkaz:
https://doaj.org/article/8c1891eebe1141d1b67d230ea5ff0c1f
Autor:
Kevin A. Lidberg, Andrew J. Annalora, Marija Jozic, Daniel J. Elson, Lu Wang, Theo K. Bammler, Susanne Ramm, Maria Beatriz Monteiro, Jonathan Himmelfarb, Craig B. Marcus, Patrick L. Iversen, Edward J. Kelly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ffc507cf83ba4185b5e5704e026f577d
Autor:
Travis K Warren, Chris A Whitehouse, Jay Wells, Lisa Welch, Jay S Charleston, Alison Heald, Donald K Nichols, Marc E Mattix, Gustavo Palacios, Jeffrey R Kugleman, Patrick L Iversen, Sina Bavari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004456 (2016)
Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer
Externí odkaz:
https://doaj.org/article/c8b3af9a51de44cb95f7da37c00b05f2
Autor:
Shannon Martin, Mariano Sanchez-Lockhart, Amy C. Shurtleff, Jeffrey R. Kugelman, Elizabeth E. Zumbrun, David L. Saunders, Travis K. Warren, Brett P. Eaton, Gustavo Palacios, Xiankun Zeng, Jens H. Kuhn, Allen J. Duplantier, Christopher L. Cooper, Farooq Nasar, Rajini Mudhasani, Rekha G. Panchal, Margaret L. Pitt, J Matthew Meinig, Ian Crozier, Chih-Yuan Chiang, Christopher D. Kane, Sandra L. Bixler, Sheli R. Radoshitzky, Karen A. Martins, Patrick L. Iversen, Melek M. E. Sunay
Publikováno v:
The Lancet. Infectious Diseases
Summary The PALM trial in the Democratic Republic of the Congo identified a statistically significant survival benefit for two monoclonal antibody-based therapeutics in the treatment of acute Ebola virus disease; however, substantial gaps remain in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b72b43f9e4b77f081311c81aadaf6d7
https://doi.org/10.1016/s1473-3099(20)30282-6
https://doi.org/10.1016/s1473-3099(20)30282-6
Publikováno v:
Drug Metabolism and Disposition. 48:272-287
The human genome encodes 48 nuclear receptor (NR) genes, whose translated products transform chemical signals from endo-xenobiotics into pleotropic RNA transcriptional profiles that refine drug metabolism. This review describes the remarkable diversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc531caf9c37a536875794aca3882ee
https://doi.org/10.1124/dmd.119.089102
https://doi.org/10.1124/dmd.119.089102