Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Patrick. J. Cimino"'
Autor:
Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, Cameron J. Herting, Ben Gabanic, José E. Velázquez Vega, Jennifer Shelton, Jeffrey M. Switchenko, James L. Ross, Leon F. McSwain, Jason T. Huse, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom, Naga Prathyusha Maturi, Patrick. J. Cimino, Eric C. Holland, Helmut Kettenmann, Cameron W. Brennan, Daniel J. Brat, Dolores Hambardzumyan
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subgroups to improve our understanding of pathogenetic mechanisms
Externí odkaz:
https://doaj.org/article/99915def14e347129ecc08b39b7bf014
Autor:
Zhichao Wu, Karen Dazelle, Zied Abdullaev, Hye-Jung Chung, Sonika Dahiya, Matthew Wood, Han Lee, Calixto-Hope G. Lucas, Qinwen Mao, Lorraina Robinson, Igor Fernandes, Matthew McCord, Peter Pytel, Kyle S. Conway, Rebecca Yoda, Jennifer M. Eschbacher, Ossama M. Maher, Martin Hasselblatt, Bret C. Mobley, Jack M. Raisanen, Kimmo J. Hatanpaa, Joshua Byers, Norman L. Lehman, Patrick J. Cimino, Drew Pratt, Martha Quezado, Kenneth Aldape
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-7 (2024)
Abstract Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and molecular characteristics. Experience is limited with respect to its molecular heterogeneity and clinical characterist
Externí odkaz:
https://doaj.org/article/ccb5b973f4b744df99cf76d1b717245c
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
Autor:
Sebastian Schmid, Zachary R. Russell, Alex Shimura Yamashita, Madeline E. West, Abigail G. Parrish, Julia Walker, Dmytro Rudoy, James Z. Yan, David C. Quist, Betemariyam N. Gessesse, Neriah Alvinez, Kimberly D. Hill, Larry W. Anderson, Patrick J. Cimino, Debra K. Kumasaka, Ralph E. Parchment, Eric C. Holland, Frank Szulzewsky
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114829- (2024)
Summary: Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosine
Externí odkaz:
https://doaj.org/article/4470af9805e444e2b122261c594c9aa1
Autor:
Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract In malignant glioma, cytotoxic drugs are often inhibited from accessing the tumor site due to the blood-tumor barrier (BTB). Ibrutinib, FDA-approved lymphoma agent, inhibits Bruton tyrosine kinase (BTK) and has previously been shown to indep
Externí odkaz:
https://doaj.org/article/e10420c2c7f8462fb3381665c144761c
Autor:
Felipe Andreiuolo, Christina K. Ferrone, Sharika Rajan, Arie Perry, Ekin Guney, Elaine Cham, Caterina Giannini, Angus Toland, Nicholas Willard, Andrea Silveira de Souza, Karen Dazelle, Hye-Jung Chung, Omkar Singh, Kyle Conway, Nicholas Coley, Christopher Dampier, Zied Abdullaev, Drew Pratt, Patrick J. Cimino, Martha Quezado, Kenneth Aldape
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Central nervous system (CNS) embryonal tumors are a heterogeneous group of high-grade malignancies, and the increasing clinical use of methylation profiling and next-generation sequencing has led to the identification of molecularly distinct
Externí odkaz:
https://doaj.org/article/4fff28e808b7469b8bce2849fa21e918
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to interpret any investigational study of diffuse gliomas in the modern era. While DNA sequencing is the gold standard for determining IDH mutational status, genome-wid
Externí odkaz:
https://doaj.org/article/7ae1cad55a3b4fa3835686acc7e09a84
Autor:
Siobhan S. Pattwell, Sonali Arora, Patrick J. Cimino, Tatsuya Ozawa, Frank Szulzewsky, Pia Hoellerbauer, Tobias Bonifert, Benjamin G. Hoffstrom, Norman E. Boiani, Hamid Bolouri, Colin E. Correnti, Barbara Oldrini, John R. Silber, Massimo Squatrito, Patrick J. Paddison, Eric C. Holland
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses a
Externí odkaz:
https://doaj.org/article/e76b737ec4c34d949cb32dc9395b4f44
Autor:
Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song, Wei Zhang, Dionne L. Davis, Nicole J. Briceno, Yang Zhang, Patrick J. Cimino, Kareem A. Zaghloul, Mark R. Gilbert, Terri S. Armstrong, Chunzhang Yang
Publikováno v:
Clinical Cancer Research. 29:1305-1316
Purpose: Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic mutations in human malignancies. Increasing evidence indicates that IDH mutations play critical roles in malignant transformation and progression. However, the therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa7df61b86c3808bfd25f0cb3f00985
https://doi.org/10.1158/1078-0432.ccr-22-3179
https://doi.org/10.1158/1078-0432.ccr-22-3179
Autor:
Rohan Kodgule, Jie Chen, Pooja Khonde, Joshua Robinson, Amy D’Albora, Lisa Cook, Catrina C. Fronick, Robert Fulton, Sridhar Nonavinkere Srivatsan, Patrick J. Cimino, Eric J. Duncavage
Publikováno v:
Blood Advances. 6:6051-6055
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c6b68138f8dc42cccbac328d03eb33
https://doi.org/10.1182/bloodadvances.2022006985
https://doi.org/10.1182/bloodadvances.2022006985
Autor:
Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino
Publikováno v:
Case Reports in Pathology, Vol 2020 (2020)
Pilocytic astrocytoma is a low-grade glial neoplasm of the central nervous system (CNS) that tends to occur in the pediatric population and less commonly presents in adults. Hereditary pilocytic astrocytoma is often associated with germline genetic a
Externí odkaz:
https://doaj.org/article/62c4dbf01dc149e0ae4df48e9d5b416b