Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Patrick. Genissel"'
Autor:
Richard J. Weaver, Biswaranjan Mohanty, Michelle L. Halls, Patrick Genissel, Craig Steven Clements, Laurent Vuillard, Christopher J.H. Porter, Indu R. Chandrashekaran, Rahul Chandrakant Patil, Bradley C. Doak, Martin Williams, Stephen J. Headey, O.V. Ilyichova, Bonan Liu, Martin J. Scanlon
Peroxisome proliferator–activated receptor α (PPARα) is a transcriptional regulator of lipid metabolism. GW7647 is a potent PPARα agonist that must reach the nucleus to activate this receptor. In cells expressing human fatty acid–binding prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d0cd4ce2d9bfc97952bae843ac2ca7
https://europepmc.org/articles/PMC6416440/
https://europepmc.org/articles/PMC6416440/
Autor:
Georges Houin, Hamid Boudra, Patrick Genissel, Sylvie Saivin, Marie Malmary, Philippe Delagrange
Publikováno v:
Arzneimittel-Forschung
Arzneimittel-Forschung, Thieme Publishing, 1999, 49 (10), pp.849-852
Arzneimittel-Forschung, Thieme Publishing, 1999, 49 (10), pp.849-852
International audience; In this study, an original surgical implantation technique in the confluens sinuum via the superior sagittal vein was developed to quantify melatonin secretion by the pineal gland. Melatonin (CAS 73-31-4) was determined using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a1688449838f0cef23ba82dd6c0c54
https://doi.org/10.1055/s-0031-1300513
https://doi.org/10.1055/s-0031-1300513
Autor:
Alain Francillon, Gisèle Pickering, Chantal Belorgey, Michel Abiteboul, Bernard Bégaud, Jehan-Michel Behier, Bénédicte Chauvin, Antoine Cournot, Rémy Defrance, Jean-Paul Demarez, Élisabeth Devilliers, Vincent Diebolt, Bertrand Diquet, Yves Donazzolo, Muriel Echemann, Christian Funck-Brentano, Patrick Genissel, Nadine Houedé, Jean-Marc Husson, Philippe Lefevre, Isabelle Macquin-Mavier, Brigitte Marchenay, Christine Marey, Laurence Negres-Pages, Séverine Pitel, Valérie Plattner, Christine Roy, Michel Sibille, Nicolas Simon, Claire Thalamas, Dominique Tremblay, Tony Waegemans
Publikováno v:
Therapies. 64:155-159
The working group focused on defining exploratory trials on medicinal products and developing recommendations for their implementation in France (notably concerning non-clinical requirements, the pharmaceutical quality of the investigational medical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eca532dd8904943ef2144fa3201cb12
https://doi.org/10.2515/therapie/2009022
https://doi.org/10.2515/therapie/2009022
Publikováno v:
Drug Metabolism and Disposition. 33:1137-1143
The aim of our study was to determine the neuropharmacokinetics of S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], a new positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27343956c827d9962602d73c0b7d8f9
https://doi.org/10.1124/dmd.105.004424
https://doi.org/10.1124/dmd.105.004424
Autor:
Patrick Genissel, Anne Dekeyne, Adrian Newman-Tancredi, Bertrand Goument, Marc Bertrand, Millan Mark, Valérie Charlot, Jean-Louis Peglion, Christian Nisole, Hélène Giraud, Nicole Despaux
Publikováno v:
Journal of Medicinal Chemistry. 45:165-176
S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT(1A) receptors, respectively. It has proven to be active in several models predictive of anxiolytic, antidepressant, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90cce17930fabc2876ec44906a8bc3b9
https://doi.org/10.1021/jm010975+
https://doi.org/10.1021/jm010975+
Autor:
Sylvie Dupin, Anne Le Quellec, Bernard Marchand, Patrick Genissel, Georges Houin, Sylvie Saivin
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 33:11-16
Probe calibrations are required for accurate estimations of extracellular concentrations in microdialysis experiments. Several methods have been developed and validated for in vivo determination of dialysis membrane recovery such as the perfusion rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21da80d7651e6af009f947ee5618589
https://doi.org/10.1016/1056-8719(94)00049-a
https://doi.org/10.1016/1056-8719(94)00049-a
Publikováno v:
Pharmaceutical Research. 11:835-838
The aim of the present study was to compare the performance of conventional equilibrium dialysis method with a microdialysis method in studying drug protein binding. The two methods were assessed by comparing the measured mean unbound drug fraction i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc3ccf5ed054ce1570a132710d134892
https://doi.org/10.1023/a:1018973607051
https://doi.org/10.1023/a:1018973607051
Autor:
Jean-Louis, Peglion, Bertrand, Goument, Nicole, Despaux, Valérie, Charlot, Hélène, Giraud, Christian, Nisole, Adrian, Newman-Tancredi, Anne, Dekeyne, Marc, Bertrand, Patrick, Genissel, Mark J, Millan
Publikováno v:
Journal of medicinal chemistry. 45(1)
S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT(1A) receptors, respectively. It has proven to be active in several models predictive of anxiolytic, antidepressant, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c96f55d5b404e851b8bbf4c2193a3e9
https://pubmed.ncbi.nlm.nih.gov/11754589
https://pubmed.ncbi.nlm.nih.gov/11754589
Publikováno v:
Neurobiology of Aging. 25:S224
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b174d0ecd00f71ce1005c05979e82ebf
https://doi.org/10.1016/s0197-4580(04)80750-4
https://doi.org/10.1016/s0197-4580(04)80750-4
Autor:
Ernst Bayer, Manfred Spraul, Patrick. Genissel, Wolfgang. Bermel, Hendrik Jan. De Jong, Klaus Albert, Manuel Kunst
Publikováno v:
Analytical Chemistry. 61:772-775
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f14bf77d40f78b3fae3f73cee4cc1f3
https://doi.org/10.1021/ac00182a027
https://doi.org/10.1021/ac00182a027