Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Patrick van Eijk"'
Autor:
Felix M. Dobbs, Patrick van Eijk, Mick D. Fellows, Luisa Loiacono, Roberto Nitsch, Simon H. Reed
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Understanding how DNA double strand breaks (DSBs) form and are repaired in the genome depends on their accurate measurement. Here the authors describe INDUCE-seq; a DSB-detection method that simultaneously measures physiological and induced breaks th
Externí odkaz:
https://doaj.org/article/108e1aee16be4a13b26b44d7b4e2a047
Autor:
Pierre Murat, Consuelo Perez, Alastair Crisp, Patrick van Eijk, Simon H. Reed, Guillaume Guilbaud, Julian E. Sale
Publikováno v:
Science advances. 8(45)
The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a specific mutational footprint at thousands of early and efficient
Autor:
Roberto Nitsch, Felix Dobbs, Patrick van Eijk, Simon H. Reed, Mick D. Fellows, Luisa Loiacono
Publikováno v:
Nature Communications
Understanding how breaks form and are repaired in the genome depends on the accurate measurement of the frequency and position of DNA double strand breaks (DSBs). This is crucial for identification of a chemical’s DNA damage potential and for safe
Publikováno v:
CIRED 2021 - The 26th International Conference and Exhibition on Electricity Distribution.
Autor:
Patrick van Eijk, Yumin Teng, Simon H. Reed, Shuvro Prokash Nandi, Mark Bennett, Shirong Yu, Matthew Leadbitter
Publikováno v:
Genome research. 29(1)
Repair of UV-induced DNA damage requires chromatin remodeling. How repair is initiated in chromatin remains largely unknown. We recently demonstrated that global genome–nucleotide excision repair (GG-NER) in chromatin is organized into domains in r
Autor:
Matthew Leadbitter, Patrick van Eijk, Yumin Teng, Shirong Yu, Simon H. Reed, Mark Bennett, Shuvro Prokash Nandi
Repair of UV-induced DNA damage requires chromatin remodeling. How repair is initiated in chromatin remains largely unknown. We recently demonstrated that Global Genome Nucleotide Excision Repair (GG-NER) in chromatin is organized into domains around
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635a37dbd08768e666c4f667009b21be
https://doi.org/10.1101/283747
https://doi.org/10.1101/283747
Autor:
Patrick, van Eijk, Yumin, Teng, Mark R, Bennet, Katie E, Evans, James R, Powell, Richard M, Webster, Simon H, Reed
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1672
The genetic information contained within the DNA molecule is highly susceptible to chemical and physical insult, caused by both endogenous and exogenous sources that can generate in the order of thousands of lesions a day in each of our cells (Lindah
Autor:
Mark R. Bennet, Katie Ellen Evans, Simon H. Reed, Yumin Teng, Patrick van Eijk, Richard Webster, James Powell
Publikováno v:
Methods in Molecular Biology ISBN: 9781493973057
The genetic information contained within the DNA molecule is highly susceptible to chemical and physical insult, caused by both endogenous and exogenous sources that can generate in the order of thousands of lesions a day in each of our cells (Lindah
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7869054118f2809fbc5fc714a7345af
https://doi.org/10.1007/978-1-4939-7306-4_7
https://doi.org/10.1007/978-1-4939-7306-4_7
Autor:
Patrick van Eijk, Shirong Yu, Rolf Kraehenbuehl, Edgar Hartsuiker, Raymond Waters, Simon H. Reed, Neil Humphryes, Zheng Zhou
Publikováno v:
Nucleic Acids Research
Regulating gene expression programmes is a central facet of the DNA damage response. The Dun1 kinase protein controls expression of many DNA damage induced genes, including the ribonucleotide reductase genes, which regulate cellular dNTP pools. Using
Autor:
Simon H. Reed, Patrick van Eijk, Yumin Teng, Stephen P. Jackson, Mark Bennett, Matthew Leadbitter, Shirong Yu, Richard Webster, Raymond Waters, Katie Ellen Evans
The rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. To study this, we measured the distribution of nucleotide excision repair (NER) rates for UV-induced lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62358ca5fca5b1aa679f0c12c5bafc9a
https://doi.org/10.1101/050807
https://doi.org/10.1101/050807