Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Patrick Younan"'
Autor:
Elizabeth Gray, Kelly Hensley, Sean Allred, Robert Thurman, Katie Snead, Michelle Ulrich, Dannah Miller, Serena Wo, Angela Epp, Disha Sahetya, Julie Hahn, Chris Frantz, Natalya Nazarenko, Kellie Spahr, Patrick Younan, Li-Ya Huang, Kristen Gahnberg, Piper M Treuting, Esther S Trueblood, John J Gosink, Evgenia Jane Haass, Mary Padilla, Alyson J Smith, Jason P Schrum, Shyra J Gardai
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background SGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic payload monomethyl auristatin E (MMAE) via a protease-cleavable maleimidocaproyl
Externí odkaz:
https://doaj.org/article/f885976e5e104e04a8016c6dbb713fb4
Autor:
Patrick Younan, Rodrigo I Santos, Palaniappan Ramanathan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Tatiana Ammosova, Michelle Meyer, Michael G Katze, Vsevolod L Popov, Sergei Nekhai, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008068 (2019)
Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly correlative with fatalities. However, the mechanisms leading to T-cell depletion remain largely unknown. Here, we demonstrate that both viral mRNAs and antigen
Externí odkaz:
https://doaj.org/article/7ea5b7073c814c918c0555489bf6afc1
Autor:
Philipp A Ilinykh, Rodrigo I Santos, Bronwyn M Gunn, Natalia A Kuzmina, Xiaoli Shen, Kai Huang, Pavlo Gilchuk, Andrew I Flyak, Patrick Younan, Galit Alter, James E Crowe, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007204 (2018)
Recent studies suggest that some monoclonal antibodies (mAbs) specific for ebolavirus glycoprotein (GP) can protect experimental animals against infections. Most mAbs isolated from ebolavirus survivors appeared to target the glycan cap or the stalk r
Externí odkaz:
https://doaj.org/article/6de2ab5e5e0a45ebb57a5f8e1d9681ec
Autor:
Natalia A. Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo I. Santos, Andrew I. Flyak, Philipp A. Ilinykh, Kai Huang, Ndongala M. Lubaki, Palaniappan Ramanathan, James E. Crowe, Jr., Alexander Bukreyev
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1802-1815.e5 (2018)
Summary: Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can protect against infection. It is currently unknown whether natural infection also induces some antibodies with the capacity for antibody-dependent enhance
Externí odkaz:
https://doaj.org/article/7731be7a37cd40b998e7c2e9e58cefde
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006932 (2018)
Externí odkaz:
https://doaj.org/article/f0dd069d206d49b984975192199db425
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific
Externí odkaz:
https://doaj.org/article/48b879ffa3974e9c88d3f79502e915e8
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT The 2013-2016 outbreak of Ebola virus (EBOV) in West Africa, which has seen intermittent reemergence since it was officially declared over in February of 2016, has demonstrated the need for the rapid development of therapeutic intervention s
Externí odkaz:
https://doaj.org/article/d26e844dbac74e27a0de1abebea9d581
Autor:
Mathieu Iampietro, Patrick Younan, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Rodrigo I Santos, Richard A Koup, Michael G Katze, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006397 (2017)
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a 'sepsis-like' syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however, th
Externí odkaz:
https://doaj.org/article/aa49fa55904441469156986efb7c5c23
Autor:
Ndongala Michel Lubaki, Patrick Younan, Rodrigo I Santos, Michelle Meyer, Mathieu Iampietro, Richard A Koup, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006031 (2016)
Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblock
Externí odkaz:
https://doaj.org/article/d4c27c0bf52446c099d7d3213b484f09
Publikováno v:
Viruses, Vol 5, Iss 12, Pp 2946-2962 (2013)
The combination of genetic modification and hematopoietic stem cell (HSC) transplantation may provide the necessary means to develop an alternative treatment option to conventional antiretroviral therapy. As HSCs give rise to all hematopoietic cell t
Externí odkaz:
https://doaj.org/article/1751de6fc77942ac97e2987990d8b7f8