Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Patrick Y. Shen"'
Autor:
Jagdeep Tuli, JungWoo Yang, Qiang Li, Qian Wang, Shiva Shafiei, Shaimaa Hussein, Wang Zheng, Xing-Zhen Chen, Patrick Y. Shen, Yuliang Wu, Jiancheng Tu, Xiao-Gai Li, Xiao-Qing Dai
Publikováno v:
Journal of Biological Chemistry. 287:6551-6561
Pkd2L1 (also called TRPP3) is a non-selective cation channel permeable to Ca(2+), Na(+), and K(+) and is activated by Ca(2+). It is also part of an acid-triggered off-response cation channel complex. We previously reported roles of the Pkd2L1 C-termi
Autor:
Xing-Zhen Chen, Wentong Long, Zahir Hussain, Shaohua Wang, Yuliang Wu, Carl X. Chen, Xiao-Qing Dai, Patrick Y. Shen, Qiang Li
Publikováno v:
Journal of Neurochemistry. 103:2391-2400
Transient receptor potential (TRP) polycystin 2 and 3 (TRPP2 and 3) are homologous members of the TRP superfamily of cation channels but have different physiological functions. TRPP2 is part of a flow sensor, and is defective in autosomal dominant po
Autor:
Xiao-Qing Dai, Chris I. Cheeseman, Xing-Zhen Chen, Nicolas Montalbetti, Patrick Y. Shen, Qiang Li, Edward Karpinski, Guanqing Wu, Horacio F. Cantiello
Publikováno v:
Human Molecular Genetics. 14:1587-1603
Polycystin-2 (PC2) is the product of the PKD2 gene, which is mutated in 10-15% patients of autosomal dominant polycystic kidney disease (ADPKD). PC2 is an integral transmembrane protein and acts as a calcium-permeable cation channel. The functional m
Autor:
Richard Sandford, Yan Liu, Lawrence B. Smillie, Xiao-Qing Dai, Xing-Zhen Chen, Qiang Li, Patrick Y. Shen, Shaohua Wang
Publikováno v:
Biochemistry. 42:7618-7625
Polycystin-L (PCL) is an isoform of polycystin-2, the product of the second gene associated with autosomal dominant polycystic kidney disease, and functions as a Ca(2+)-regulated nonselective cation channel. We recently demonstrated that polycystin-2
Autor:
Horacio F. Cantiello, Xiao-Qing Dai, Qiang Li, Edward Karpinski, Xing-Zhen Chen, Patrick Y. Shen
Publikováno v:
FEBS letters. 576(1-2)
The tandem affinity purification (TAP) procedure was initially developed as a tool for rapid purification of native protein complexes expressed at their natural levels in yeast cells. This purification procedure was also applied to study interactions
Publikováno v:
Biochemistry. 42(2)
Polycystin-2 (PC2), encoded by the PKD2 gene, is mutated in 10-15% of autosomal dominant polycystic kidney disease (ADPKD) patients. PC2 is a Ca(2+)-permeable nonselective cation channel and is present in kidney and many other organs. Likewise, PKD2-