Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Patrick Y. P. Kao"'
1
Pathway analysis of complex diseases for GWAS, extending to consider rare variants, multi-omics and interactions
Autor: Maurice Yap, Shea Ping Yip, Kim Hung Leung, Patrick Y. P. Kao, Lawrence W. C. Chan
Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:335-353
Background Genome-wide association studies (GWAS) is a major method for studying the genetics of complex diseases. Finding all sequence variants to explain fully the aetiology of a disease is difficult because of their small effect sizes. To better e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d218907b5699a7676def652be79f55e1
https://doi.org/10.1016/j.bbagen.2016.11.030
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2
Genetic Polymorphisms in Estrogen Metabolic Pathway Associated with Risks of Alzheimer's Disease: Evidence from a Southern Chinese Population
Autor: Lu Hua Chen, You-Qiang Song, Patrick Y. P. Kao, Yanhui Fan, Joyce Ha, Leung-Wing Chu, Deborah Tip Yin Ho
Publikováno v: Journal of the American Geriatrics Society. 65:332-339
Objectives To investigate whether genetic variations on the estrogen metabolic pathway would be associated with risk of Alzheimer's disease (AD). Design Cross-sectional study. Setting Individuals were recruited at the Memory Clinic, Queen Mary Hospit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f163829af43990f63bb56bbcbb5b5f
https://doi.org/10.1111/jgs.14537
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3
Genetic Association Study of KCNQ5 Polymorphisms with High Myopia
Autor: Maurice Yap, Kim Hung Leung, Long Qian Liu, Shea Ping Yip, Patrick Y. P. Kao, Xuan Liao
Publikováno v: BioMed Research International, Vol 2017 (2017)
BioMed Research International
Identification of genetic variations related to high myopia may advance our knowledge of the etiopathogenesis of refractive error. This study investigated the role of potassium channel gene (KCNQ5) polymorphisms in high myopia. We performed a case-co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a9fdef9132b1ff4bbcd337672e3718
https://doi.org/10.1155/2017/3024156
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4
Etiology of developmental spinal stenosis: A genome-wide association study
Autor: Patrick Y. P. Kao, Dino Samartzis, Pak C. Sham, Kathryn S.E. Cheah, Kenneth M.C. Cheung, Daniel W. Chan, Jason Pui Yin Cheung
Publikováno v: Journal of Orthopaedic Research.
Our study aimed to identify possible single nucleotide polymorphisms (SNPs) via a genome-wide association study (GWAS) approach and a candidate gene platform that were associated with lumbar developmental spinal stenosis (DSS). Southern Chinese popul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::307de3c84a5b015d4810901144c71170
https://doi.org/10.1002/jor.23746
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5
Etiology of developmental spinal stenosis: A genome-wide association study
Autor: Jason P Y, Cheung, Patrick Y P, Kao, Pak, Sham, Kathryn S E, Cheah, Danny, Chan, Kenneth M C, Cheung, Dino, Samartzis
Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 36(4)
Our study aimed to identify possible single nucleotide polymorphisms (SNPs) via a genome-wide association study (GWAS) approach and a candidate gene platform that were associated with lumbar developmental spinal stenosis (DSS). Southern Chinese popul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffd6a74a09d2d573c46b32b6f30c2e47
https://pubmed.ncbi.nlm.nih.gov/28983962
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6
Genetic susceptibility of lumbar degenerative disc disease in young Indian adults
Autor: Kenneth M.C. Cheung, Daniel W. Chan, Anita Yee, Veera Ranjani, Muthuraja Raveendran, Senthil Natesan, Rishi Mugesh Kanna, Patrick Y. P. Kao, S. Rajasekaran, Ajoy Prasad Shetty
Publikováno v: European Spine Journal. 24:1969-1975
Although the exact mechanisms that lead to degenerative disc disease (DDD) are not well understood, a significant genetic influence has been found. Focusing on DDD that occurs in young adults can be valuable in determining the exact role of genetic p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefd74e17d4255eb6d7ca8b8d68302cc
https://doi.org/10.1007/s00586-014-3687-y
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7
Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes
Autor: Senthil Natesan, Ajoy Prasad Shetty, Daniel W. Chan, Rajasekaran Shanmuganathan, Rishi Mugesh Kanna, Patrick Y. P. Kao, Raveendran Muthuraja, Anita Yee, Veera Ranjani Rajagopalan, Kenneth M.C. Cheung
Publikováno v: Asian Spine Journal
Asian Spine Journal, Vol 11, Iss 4, Pp 594-600 (2017)
Study DesignA prospective genetic association study.PurposeThe etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9998eb22c464dc73d96b58339fb76d96
https://pubmed.ncbi.nlm.nih.gov/28874978
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8
How Reliable Are the Reported Genetic Associations in Disc Degeneration?: The Influence of Phenotypes, Age, Population Size, and Inclusion Sequence in 809 Patients
Autor: S. Rajasekaran, Anita Yee, Ajoy Prasad Shetty, Patrick Y. P. Kao, Rishi Mugesh Kanna, Kenneth M.C. Cheung, Ranjani Raja Reddy, Muthuraja Raveendran, Daniel W. Chan, Senthil Natesan
Publikováno v: Spine. 41(21)
Study design Prospective genetic association study. Objective The aim of this study was to document the variations in the genetic associations, when different magnetic resonance imaging (MRI) phenotypes, age stratification, cohort size, and sequence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85113a7647b312861495f8b75b0a988
https://pubmed.ncbi.nlm.nih.gov/27513226
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10
(iii) Whole-genome association studies of complex diseases
Autor: Stacey S. Cherny, Kenneth M.C. Cheung, Patrick Y. P. Kao, Daniel W. Chan, Pak C. Sham, You-Qiang Song
Publikováno v: Current Orthopaedics. 22:251-258
Summary Understanding how the variable co-action and interaction of multiple genetic and environmental factors lead to disease occurrence may lead to novel prevention and intervention strategies. Whole-genome association (WGA) or genome-wide associat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a8ad4a74070ab8fb91f4ddb43186e7c
https://doi.org/10.1016/j.cuor.2008.05.006
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