Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy

Autor: Al-Hassan J. Dajani, Michael B. Liu, Michael A. Olaopa, Lucian Cao, Carla Valenzuela-Ripoll, Timothy J. Davis, Megan D. Poston, Elizabeth H. Smith, Jaime Contreras, Marissa Pennino, Christopher M. Waldmann, Donald B. Hoover, Jason T. Lee, Patrick Y. Jay, Ali Javaheri, Roger Slavik, Zhilin Qu, Olujimi A. Ajijola

Publikováno v: JCI Insight, Vol 8, Iss 22 (2023)

Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic innervation.

Externí odkaz: https://doaj.org/article/f4114ea52f29464d8884c3ab4fa28051

Repurposing Normal Chromosomal Microarray Data to Harbor Genetic Insights into Congenital Heart Disease

Autor: Nephi A. Walton, Hoang H. Nguyen, Sara S. Procknow, Darren Johnson, Alexander Anzelmi, Patrick Y. Jay

Publikováno v: Biology, Vol 12, Iss 10, p 1290 (2023)

About 15% of congenital heart disease (CHD) patients have a known pathogenic copy number variant. The majority of their chromosomal microarray (CMA) tests are deemed normal. Diagnostic interpretation typically ignores microdeletions smaller than 100

Externí odkaz: https://doaj.org/article/d551611b75e04d4a96ee22f50fb8b688

Author response: Tiered sympathetic control of cardiac function revealed by viral tracing and single cell transcriptome profiling

Autor: Russell Littman, Sachin Sharma, John D Tompkins, Douglas Arneson, Jaime Contreras, Al-Hassan Dajani, Kaitlyn Ang, Amit Tsanhani, Xin Sun, Patrick Y Jay, Herbert Herzog, Xia Yang, Olujimi A Ajijola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0241112f43480f9836e0aa6cfad96d20
https://doi.org/10.7554/elife.86295.sa2

137 PRIMARY RESULTS FROM APOLLO-B, A PHASE 3 STUDY OF PATISIRAN IN PATIENTS WITH TRANSTHYRETIN-MEDIATED AMYLOIDOSIS WITH CARDIOMYOPATHY

Autor: Simone Longhi(on Behalf Of), Mathew S Maurer, Marianna Fontana, John L Berk, Finn Gustafsson, Marcos Simões, Martha Grogan, Fábio Fernandes, Robert L Gottlieb, Milos Kubanek, Steen Poulsen, Thibaud Damy, Igor Diemberger, Nobuhiro Tahara, Wen-chuhg Yu, W H Wilson Tang, Laura Obici, Alejandra González-duarte, Yoshiki Sekijima, Matthew T White, Elena Yureneva, Patrick Y Jay, John Vest, Julian D Gillmore

Publikováno v: European Heart Journal Supplements. 24

Background Transthyretin-mediated (ATTR) amyloidosis is a rapidly progressive, debilitating, and fatal disease caused by misfolded TTR accumulating in multiple organs and tissues. Patients with hereditary (hATTR) amyloidosis (also known as ATTRv amyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1073432138072ace03b7d8ecbd22a8e3
https://doi.org/10.1093/eurheartjsupp/suac121.630

Gene Silencing Therapeutics in Cardiology: A Review Article

Autor: Laura Saltonstall, Lisa Duarte, Martin A. Maier, Ilia Antonino, Patrick Y. Jay, John Vest

Publikováno v: International Journal of Cardiovascular Sciences v.35 n.5 2022
International Journal of Cardiovascular Sciences
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
International Journal of Cardiovascular Sciences, Issue: ahead, Published: 26 JUL 2021
International Journal of Cardiovascular Sciences, Volume: 35, Issue: 5, Pages: 665-675, Published: 26 JUL 2021

Therapeutics that inhibit enzymes, receptors, ion channels, and cotransporters have long been the mainstay of cardiovascular medicine. Now, oligonucleotide therapeutics offer a modern variation on this paradigm of protein inhibition. Rather than targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4bf8ecb6d83d4b9c7fe122bccfbd42
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472022000500665