Zobrazeno 1 - 10
of 6 685
pro vyhledávání: '"Patrick Y"'
Autor:
Pauline Latzer, Henning Zelba, Florian Battke, Annekathrin Reinhardt, Borong Shao, Oliver Bartsch, Armin Rabsteyn, Johannes Harter, Martin Schulze, Thomas Okech, Alexander Golf, Christina Kyzirakos-Feger, Simone Kayser, Natalia Pieper, Magdalena Feldhahn, Julian Wünsche, Christian Seitz, Dirk Hadaschik, Claus Garbe, Till-Karsten Hauser, Christian la Fougère, Dirk Biskup, Dawn Brooke, David Parker, Uwe M. Martens, Gerald Illerhaus, Deborah T. Blumenthal, Ryan Merrell, Luisa Sánchez Lorenzo, Máté Hidvégi, Paula de Robles, Sied Kebir, William W. Li, Vincent W. Li, Matthew Williams, Alexandra M. Miller, Santosh Kesari, Michael Castro, Annick Desjardins, David M. Ashley, Henry S. Friedman, Patrick Y. Wen, Elisabeth C. Neil, Fabio M. Iwamoto, Bence Sipos, Karsten Geletneky, Lars Zender, Martin Glas, David A. Reardon, Saskia Biskup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal with limited survival. Tumors from 173 GBM patients are analysed for somatic mutations to generate a personalized
Externí odkaz:
https://doaj.org/article/98a07e6f1b4647369483ebef527a8f94
Autor:
Jian Jenny Chen, Melanie Y. Vincent, Dale Shepard, David Peereboom, Devalingam Mahalingam, James Battiste, Manish R. Patel, Dejan Juric, Patrick Y. Wen, Andrea Bullock, Jennifer Eva Selfridge, Shubham Pant, Joyce Liu, Wendy Li, Susanne Fyfe, Suming Wang, Victor Zota, James Mahoney, Randolph S. Watnick, Michael Cieslewicz, Jing Watnick
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-15 (2024)
Abstract Background Preclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of thrombospondin-1 (TSP-1) and reprograms the tumor microenvironment. We recently reported data from the
Externí odkaz:
https://doaj.org/article/57a3efddeea846a6bc779e0ffb283b62
Autor:
Patrick Y. A. Reinke, Robin Schubert, Dominik Oberthür, Marina Galchenkova, Aida Rahmani Mashhour, Sebastian Günther, Anaïs Chretien, Adam Round, Brandon Charles Seychell, Brenna Norton-Baker, Chan Kim, Christina Schmidt, Faisal H. M. Koua, Alexandra Tolstikova, Wiebke Ewert, Gisel Esperanza Peña Murillo, Grant Mills, Henry Kirkwood, Hévila Brognaro, Huijong Han, Jayanath Koliyadu, Joachim Schulz, Johan Bielecki, Julia Lieske, Julia Maracke, Juraj Knoska, Kristina Lorenzen, Lea Brings, Marcin Sikorski, Marco Kloos, Mohammad Vakili, Patrik Vagovic, Philipp Middendorf, Raphael de Wijn, Richard Bean, Romain Letrun, Seonghyun Han, Sven Falke, Tian Geng, Tokushi Sato, Vasundara Srinivasan, Yoonhee Kim, Oleksandr M. Yefanov, Luca Gelisio, Tobias Beck, Andrew S. Doré, Adrian P. Mancuso, Christian Betzel, Saša Bajt, Lars Redecke, Henry N. Chapman, Alke Meents, Dušan Turk, Winfried Hinrichs, Thomas J. Lane
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The main protease (Mpro) of SARS-CoV-2 is critical for viral function and a key drug target. Mpro is only active when reduced; turnover ceases upon oxidation but is restored by re-reduction. This suggests the system has evolved to survive pe
Externí odkaz:
https://doaj.org/article/7a737b71ae764265a7f11a3df650ea0b
Publikováno v:
Metabolic Engineering Communications, Vol 19, Iss , Pp e00246- (2024)
Incorporation of irreversible steps in pathway design enhances the overall thermodynamic favorability and often leads to better bioconversion yield given functional enzymes. Using this concept, here we constructed the first non-natural itaconate bios
Externí odkaz:
https://doaj.org/article/84a39d7ca46b41df917fb29864741a06
Publikováno v:
Chemical Engineering Transactions, Vol 110 (2024)
This study delves into the mechanistic modelling of literature results for the adsorption of aqueous Pb(II) by metabolically inhibited bacterial cultures from the industrial sector. Employing a multi-compartmented mathematical model based on Langmuir
Externí odkaz:
https://doaj.org/article/e6bc9f29a83a4d8db92070108887336e
Autor:
Daouda M. Gueye, Alioune Badara Ly, Babacar Gueye, Papa Ibrahima Ndour, Nancy Fullman, Patrick Y. Liu, Khadim Mbaye, Aliou Diallo, Ibrahima Diatta, Saly Amos Diatta, Mouhamadou Moustapha Mane, Gloria Ikilezi, Moussa Sarr
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-11 (2024)
Abstract Having a geolocated list of all facilities in a country – a “master facility list” (MFL) – can provide critical inputs for health program planning and implementation. To the best of our knowledge, Senegal has never had a centralized
Externí odkaz:
https://doaj.org/article/7af9f029bc61459bbaf3eb259cf9e388
Autor:
Patrick Y. A. Reinke, Edmarcia Elisa de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karničar, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Viviane Fongaro Botosso, Gláucia Maria Machado Santelli, Josana Kapronezai, Marcelo Valdemir de Araújo, Taiana Tainá Silva-Pereira, Antônio Francisco de Souza Filho, Mariana Silva Tavares, Lizdany Flórez-Álvarez, Danielle Bruna Leal de Oliveira, Edison Luiz Durigon, Paula Roberta Giaretta, Marcos Bryan Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry N. Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa L. Latham, Ana Marcia de Sá Guimarães, Dusan Turk, Carsten Wrenger, Alke Meents
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we s
Externí odkaz:
https://doaj.org/article/959ee7d783844cc0965882267049dc4f
Autor:
Branly Kilola Mbunga, Patrick Y. Liu, Freddy Bangelesa, Eric Mafuta, Nkamba Mukadi Dalau, Landry Egbende, Nicole A. Hoff, Jean Bosco Kasonga, Aimée Lulebo, Deogratias Manirakiza, Adèle Mudipanu, Nono Mvuama, Paul Ouma, Kerry Wong, Paul Lusamba, Roy Burstein
Publikováno v:
Vaccines, Vol 12, Iss 6, p 617 (2024)
Despite efforts to increase childhood vaccination coverage in the Democratic Republic of the Congo (DRC), approximately 20% of infants have not started their routine immunization schedule (zero-dose). The present study aims to evaluate the relative i
Externí odkaz:
https://doaj.org/article/725e6d99cd3a46c8b8d0b0c4ade607b1
Autor:
David Cella, Patrick Y. Wen, Claire Ervin, Susan Vallow, Isabelle Gilloteau, Carla DeMuro, Margaret Mordin, Andrea Chassot Agostinho, Jennifer Dine
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13637-13648 (2023)
Abstract Background Despite the high prevalence of brain metastases (BM) secondary to non–small‐cell lung cancer (NSCLC) (NSCLC/BM), patients' experiences (symptoms and impacts) are not fully understood. This study sought to understand the patien
Externí odkaz:
https://doaj.org/article/9cf438b01c8a48748a812c57f47a36b8
Autor:
Sebastian M. Christ, Gilbert Youssef, Shyam K. Tanguturi, Daniel Cagney, Diana Shi, J. Ricardo McFaline-Figueroa, Ugonma Chukwueke, Eudocia Q. Lee, Caroline Hertler, Nicolaus Andratschke, Michael Weller, David A. Reardon, Daphne Haas-Kogan, Matthias Guckenberger, Patrick Y. Wen, Rifaquat Rahman
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 44, Iss , Pp 100697- (2024)
Introduction and background: While recurrent glioblastoma patients are often treated with re-irradiation, there is limited data on the use of re-irradiation in the setting of bevacizumab (BEV), temozolomide (TMZ) re-challenge, or immune checkpoint in
Externí odkaz:
https://doaj.org/article/25491ed7bda84b609fc4d99318463fa8