Výsledky vyhledávání - "Patrick Wellington"

Akademický článek

Diallyl Disulfide Induces Chemosensitization to Sorafenib, Autophagy, and Cell Cycle Arrest and Inhibits Invasion in Hepatocellular Carcinoma

Autor: Ana Rita Thomazela Machado, Katiuska Tuttis, Patrick Wellington da Silva Santos, Alexandre Ferro Aissa, Lusânia Maria Greggi Antunes

Publikováno v: Pharmaceutics, Vol 14, Iss 12, p 2582 (2022)

Hepatocellular carcinoma is the seventh most common type of cancer in the world, with limited treatment options. A promising strategy to treat cancer is to associate chemotherapeutics and plant bioactive compounds. Here, we examined whether diallyl d

Externí odkaz: https://doaj.org/article/bf113671e3364b42ab81f8fd7e2327a4

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Akademický článek

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Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells

Autor: Antunes, Katiuska Tuttis, Ana Rita Thomazela Machado, Patrick Wellington da Silva Santos, Lusânia Maria Greggi

Publikováno v: Nutrients; Volume 15; Issue 12; Pages: 2742

Prostate cancer ranks second in incidence worldwide. To date, there are no available therapies to effectively treat advanced and metastatic prostate cancer. Sulforaphane and vitamin D alone are promising anticancer agents in vitro and in vivo, but th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::9ace19d03a0585b355eb32862dfd1ced

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Akademický článek

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Akademický článek

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p-synephrine induces transcriptional changes via the cAMP/PKA pathway but not cytotoxicity or mutagenicity in human gastrointestinal cells

Autor: Alexandre Ferro Aissa, Patrick Wellington da Silva dos Santos, Carla Botelho Machado, Gustavo Rafael Mazzaron Barcelos, Diego Luis Ribeiro, Ana Rita Thomazela Machado, Lusânia Maria Greggi Antunes

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

p-Synephrine (SN) is an alkaloid added to thermogenic formulations for weight loss that is predominantly absorbed in the human gastrointestinal tract (GI). As the adverse effects of SN on GI cells ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dfabb3e6e33421cfe1e607f97c9b83
https://doi.org/10.1080/15287394.2020.1855490

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Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets

Autor: Alexandre Ferro Aissa, Volodymyr P. Tryndyak, Aline de Conti, Ana Rita Thomazela Machado, Katiuska Tuttis, Carla da Silva Machado, Lívia Cristina Hernandes, Patrick Wellington da Silva Santos, Juliana Mara Serpeloni, Igor P Pogribny, Lusânia Maria Greggi Antunes

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 163

A diet deficient in donors of methyl group, such as methionine, affects DNA methylation and hepatic lipid metabolism. Methionine also affects other epigenetic mechanisms, such as microRNAs. We investigated the effects of methionine-supplemented or me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54b9e81dae6c511ca0ebf68cdab5e51
https://pubmed.ncbi.nlm.nih.gov/35314295

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Analysis of the cytotoxic, genotoxic, mutagenic, and pro-oxidant effect of synephrine, a component of thermogenic supplements, in human hepatic cells in vitro

Autor: Carla da Silva Machado, Ana Rita Thomazela Machado, Diego Luis Ribeiro, Patrick Wellington da Silva dos Santos, Gustavo Rafael Mazzaron Barcelos, Lusânia Maria Greggi Antunes, Alexandre Ferro Aissa

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Thermogenic supplements containing synephrine (SN) are widely used to weight loss. SN is a proto-alkaloid naturally found in the bark of immature fruits of Citrus aurantium (bitter orange) that has been added to thermogenic supplements due to its che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457de9c49fec98ebbf8db9236dd92ef3
https://doi.org/10.1016/j.tox.2019.04.010

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