Výsledky vyhledávání - "Patrick W. P. Ng"

Localization of Receptor Binding Sites and Functional Domains in Human Lymphotoxin (TNF-�)

Autor: Cynthia R. Goh, Chong Seng Loh, Patrick W. P. Ng, Roger H. Pain, Alan G. Porter, Roman Hlodan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f609ee2febe76feed980c46df8bd0616
https://doi.org/10.1159/000422173

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Gene expressions in Jurkat cells poisoned by a sulphur mustard vesicant and the induction of apoptosis

Autor: Peng Zhang, William J. Smith, Diana Caridha, Steven L. Zeichner, Peter K. Chiang, Richard A Leach, Mark J. Novak, Patrick W P Ng, Ludmila V. Asher

Publikováno v: British Journal of Pharmacology. 137:245-252

2 Akt (PKB), a pivotal protein kinase which can block apoptosis and promotes cell survival, was identified to be chiefly down-regulated in a dose-dependent manner following CEES treatment. Functional analysis showed that the attendant Akt activity wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb454082df49924cb5844358457078a6
https://doi.org/10.1038/sj.bjp.0704856

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Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

Autor: Reiner U. Jänicke, Alan G. Porter, Michael L. Sprengart, Patrick W. P. Ng

Publikováno v: Journal of Biological Chemistry. 273:15540-15545

Although the commonly activated death protease caspase-3 appears not to be essential for apoptosis during development except in the brain, it was not shown whether substrates known to be cleaved by caspase-3 are still proteolyzed in its absence. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b8ee9dcc5ee249cff6af9cdee2c4dd
https://doi.org/10.1074/jbc.273.25.15540

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Death substrates come alive

Autor: Alan G. Porter, Patrick W. P. Ng, Reiner U. Jänicke

Publikováno v: BioEssays. 19:501-507

Interleukin 1 beta-converting enzyme (ICE)-like proteases (caspases) play an important role in programmed cell death (apoptosis), and elucidating the consequences of their proteolytic activity is central to our understanding of the molecular mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b0cfeddbf78b0c323c96fe0bbf6ef08
https://doi.org/10.1002/bies.950190609

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Efficient and Rapid Affinity Purification of Proteins Using Recombinant Fusion Proteases

Autor: P. A. Walker, Shyh-Han Tan, David Murphy, L. E.-C. Leong, Sarah Waller, Alan G. Porter, Patrick W. P. Ng

Publikováno v: Nature Biotechnology. 12:601-605

In the affinity purification of recombinant fusion proteins, the rate-limiting step is usually the efficient proteolytic cleavage and removal of the affinity tail and the protease from the purified recombinant protein. We have developed a rapid, conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3e49583489ac6fe588f83e40f9e6bd
https://doi.org/10.1038/nbt0694-601

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Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation

Autor: Yi Chen, Patrick W P Ng, Yoichi Iwanaga, Jeffrey M. Trent, Steven L. Zeichner, Michael L. Bittner, Gerald C. Gooden, Paul S. Meltzer, Hidekatsu Iha, Yuan Jiang, Kuan-Teh Jeang

Publikováno v: Oncogene. 20(33)

The Tax protein of human T-lymphotropic virus type 1 (HTLV-1), an oncoprotein that transactivates viral and cellular genes, plays a key role in HTLV-1 replication and pathogenesis. We used cDNA microarrays to examine Tax-mediated transcriptional chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2deacda5a287469b199d88a4f434382e
https://pubmed.ncbi.nlm.nih.gov/11494144

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Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10

Autor: Patrick W. P. Ng, Reiner U. Jänicke, Alan G. Porter

Publikováno v: The Journal of biological chemistry. 274(15)

Caspase-10/a (Mch4) and caspase-10/b (FLICE2) are related death effector domain-containing cysteine aspartases presumed to be at or near the apex of apoptotic signaling pathways. We report the cloning and characterization of two novel proteins that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161abe10b9d52a78e864d789db3c8972
https://pubmed.ncbi.nlm.nih.gov/10187817

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Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-kappa B activation

Autor: Patrick W. P. Ng, Alan G. Porter, Reiner U. Jänicke

Publikováno v: Biochemical and biophysical research communications. 244(3)

We demonstrate that a 41 amino acid region (amino acids 379 to 419) in the cytoplasmic domain of tumor necrosis factor receptor 2 (TNFR2) is phosphorylated by unidentified kinase(s) both in vitro and in vivo. This domain (denoted x1c) corresponds alm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f01f304940c908129d4be162d437499
https://pubmed.ncbi.nlm.nih.gov/9535738

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CD81 engineered with endocytotic signals mediates HCV cell entry: implications for receptor usage by HCV in vivo

Autor: Yee-Joo Tan, Seng Gee Lim, Phuay-Yee Goh, Y. H. Tan, Wanjin Hong, Patrick W. P. Ng, Siew-Pheng Lim

Publikováno v: Virology. (2):250-269

Although CD81 has been shown to bind HCV E2 protein, its role as a receptor for HCV remains controversial. In this study, we constructed two CD81 chimeras by linking the cytoplasmic domains of recycling surface receptors, low-density lipoprotein rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5124e272416476481a634086b7beae5

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