Výsledky vyhledávání - "Patrick W. Gray"

Akademický článek

Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Emerging cancers are sculpted by neo-Darwinian selection for superior growth and survival but minimal immunogenicity; consequently, metastatic cancers often evolve common genetic and epigenetic signatures to elude immune surveillance. Immune subversi

Externí odkaz: https://doaj.org/article/9ef704380f1b4fca8eab24f38e67eb02

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Akademický článek

Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network.

Autor: Munehisa Yabuki, W Jason Cummings, John B Leppard, Robert M Immormino, Christi L Wood, Daniel S Allison, Patrick W Gray, Larry W Tjoelker, Nancy Maizels

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e36032 (2012)

Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming, with no guarantee of success. We

Externí odkaz: https://doaj.org/article/a23b053ae13444a0a46f729efdb2b925

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Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats

Autor: Yuti Chernajovsky, Alex N. F. Brown, Marc Feldmann, K Barrett, Margaretha Gadnell, Martin R Turner, Anna-Maija Kissonerghis, Patrick W. Gray, Anne E. Corcoran

Two soluble tumour-necrosis-factor-alpha(TNF)-binding proteins are derived from the extracellular domains of the p55 and p75 TNF receptors. They are considered to play a pivotal regulatory role in TNF-mediated inflammatory processes, including diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1159d2591c558cab42636b83ab8d1930
https://ora.ox.ac.uk/objects/uuid:da416ef3-edef-4cbe-98d2-a748ab8754d0

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Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis

Autor: Takashi Nakayama, Takao Fujisawa, David Chantry, Patrick W. Gray, Atsushi Morita, Yoshiko Kato, K. Iguchi, Osamu Yoshie, H. Kamiya, Ryuji Suzuki, Ryuichi Fujisawa, Hisashi Nishimori, Hajime Katsumata

Publikováno v: Journal of Allergy and Clinical Immunology. 110:139-146

T(H)2 cells and eosinophils selectively express CC chemokine receptor 4 and CCR3, respectively, and their chemokine ligands are likely to play important roles in the pathogenesis of atopic dermatitis (AD).The purpose of this study was to demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208c568d9d553125edbf6d8af356fdfe
https://doi.org/10.1067/mai.2002.126079

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Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands

Autor: Sam Hibbitts, Patrick W. Gray, Jacqueline D. Reeves, Johnny T. Stine, Paul R. Clapham, Graham Simmons, Amanda E. I. Proudfoot

Publikováno v: Immunological Reviews. 177:112-126

Human and simian immunodeficiency viruses (HIV and SIV) require a seven transmembrane chemokine (7TM) receptor in addition to CD4 for efficient entry into cells. CCR5 and CXCR4 act as major co-receptors for non-syncytium-inducing and syncytium-induci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::455e67e6499b4b532044cba113e08e08
https://doi.org/10.1034/j.1600-065x.2000.17719.x

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Macrophage-derived chemokine production by activated human T cellsin vitro andin vivo: preferential association with the production of type 2 cytokines

Autor: Sergio Romagnani, Enrico Maggi, David Chantry, Elena Lazzeri, Roberto Manetti, Grazia Galli, Patrick W. Gray, Paola Romagnani, Lorenzo Cosmi, Francesco Annunziato

Publikováno v: European Journal of Immunology. 30:204-210

Macrophage-derived chemokine (MDC), a potent chemoattractant for chronically activated Th2 lymphocytes, is constitutively expressed by dendritic cells, B cells, macrophages, and thymic medullary epithelial cells, whereas monocytes, NK cells, and T ly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::361434c586504618523dc7f94a49f6b2
https://doi.org/10.1002/1521-4141(200001)30:1<204::aid-immu204>3.0.co

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Macrophage-Derived Chemokine Is Localized to Thymic Medullary Epithelial Cells and Is a Chemoattractant for CD3+, CD4+, CD8low Thymocytes

Autor: Christi L. Wood, David Chantry, Patrick W. Gray, Carol J. Raport, Sergio Romagnani, Angela Epp, Paola Romagnani

Publikováno v: Blood. 94:1890-1898

Macrophage-derived chemokine (MDC) is a recently identified CC chemokine that is a potent chemoattractant for dendritic cells, natural killer (NK) cells, and the Th2 subset of peripheral blood T cells. In normal tissues, MDC mRNA is expressed princip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc1d4fe050551b99bc0a0f5e0876b9d2
https://doi.org/10.1182/blood.v94.6.1890

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Macrophage-Derived Chemokine Is Localized to Thymic Medullary Epithelial Cells and Is a Chemoattractant for CD3+, CD4+, CD8low Thymocytes

Autor: David Chantry, Paola Romagnani, Carol J. Raport, Christi L. Wood, Angela Epp, Sergio Romagnani, Patrick W. Gray

Publikováno v: Blood. 94:1890-1898

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f5c6c6d427ae32d10c75b3eab40453e
https://doi.org/10.1182/blood.v94.6.1890.418k07_1890_1898

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Molecular Basis of the Interaction between Plasma Platelet-activating Factor Acetylhydrolase and Low Density Lipoprotein

Autor: Stephen M. Prescott, Sally P.A. McCormick, Stephen G. Young, Thomas M. McIntyre, Darius Vaitkus, Patrick W. Gray, Larry W. Tjoelker, Diana M. Stafforini

Publikováno v: Journal of Biological Chemistry. 274:7018-7024

The platelet-activating factor acetylhydrolases are enzymes that were initially characterized by their ability to hydrolyze platelet-activating factor (PAF). In human plasma, PAF acetylhydrolase (EC 3.1.1.47) circulates in a complex with low density

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2989c08b7145ec959679436d5bca0ca1
https://doi.org/10.1074/jbc.274.11.7018

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Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

Autor: Kouji Matsushima, Mayumi Kakizaki, Patrick W. Gray, Toshio Imai, Shin Takagi, Jian-bin Wang, Osamu Yoshie, Miyuki Nishimura, Morio Nagira

Publikováno v: International Immunology. 11:81-88

Helper T cells are classified into Th1 and Th2 subsets based on their profiles of cytokine production. Th1 cells are involved in cell-mediated immunity, whereas Th2 cells induce humoral responses. Selective recruitment of these two subsets depends on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e03d0d78dc49f81194f70f95e49450
https://doi.org/10.1093/intimm/11.1.81

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