Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrick W. Bilder"'
Autor:
Susanne Burger, Suman Laal, Eric Leibert, Patrick W. Bilder, Steven C. Almo, Elisabeth Jenny-Avital, Jacqueline M. Achkar, Arturo Casadevall, Xian Yu
Publikováno v:
Clinical and Vaccine Immunology. 17:384-392
The immunodominance of Mycobacterium tuberculosis proteins malate synthase (MS) and MPT51 has been demonstrated in case-control studies with patients from countries in which tuberculosis (TB) is endemic. The value of these antigens for the serodiagno
Autor:
John Lawrence Andreassi, Thomas S. Leyh, Matthew W. Vetting, Patrick W. Bilder, Steven L. Roderick
Publikováno v:
Biochemistry. 48:6461-6468
The isoprenoid family of compounds contains roughly 25,000 distinct natural products (1, 2), and the classes within the family are often chemically sufficiently diverse to provide the extensive functional overlap often seen in robust metabolic system
Autor:
Thomas S. Leyh, Patrick W. Bilder, Steven L. Roderick, John Lawrence Andreassi, Matthew W. Vetting
Publikováno v:
Protein Science. 16:983-989
Streptococcus pneumoniae, a ubiquitous gram-positive pathogen with an alarming, steadily evolving resistance to frontline antimicrobials, poses a severe global health threat both in the community and in the clinic. The recent discovery that diphospho
Publikováno v:
Biochemistry. 43:133-139
IscA belongs to an ancient family of proteins responsible for iron-sulfur cluster assembly in essential metabolic pathways preserved throughout evolution. We report here the 2.3 A resolution crystal structure of Escherichia coli IscA, a novel fold in
Autor:
Guofeng Zhu, Melvin So, Patrick W. Bilder, Joshua E. Drumm, Steve C. Almo, John D. Chan, Ian M. Orme, Kaixia Mi, Angelo Izzo, Meihao Sun, Randall J. Basaraba, Helle Bielefeldt-Ohmann, Jihyeon Lim, Thomas S. Leyh, JoAnn M. Tufariello
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9 (2009)
PLoS Pathogens
PLoS Pathogens
Autor:
Grover L. Waldrop, Marcia E. Newcomer, Loola Al-Kassim, Graeme Bainbridge, Jeffrey F. Ohren, Cindy Spessard, Susan Holley, Sandra Lightle, Patrick W. Bilder, Barry C. Finzel, Michael Melnick, Fang Sun
Publikováno v:
Biochemistry. 45(6)
Acetyl-coA carboxylase (ACC) is a central metabolic enzyme that catalyzes the committed step in fatty acid biosynthesis: biotin-dependent conversion of acetyl-coA to malonyl-coA. The bacterial carboxyltransferase (CT) subunit of ACC is a target for t
Autor:
Kaixia Mi, Guofeng Zhu, Ian M. Orme, Jo Ann M. Tufariello, Randall J. Basaraba, Angelo Izzo, Joshua E. Drumm, Patrick W. Bilder, Jihyeon Lim, Helle Bielefeldt-Ohmann, Steve C. Almo, Meihao Sun, Thomas S. Leyh, John Chan, Melvin So
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 5, Iss 5, p e1000460 (2009)
PLoS Pathogens, Vol 5, Iss 5, p e1000460 (2009)
Tuberculous latency and reactivation play a significant role in the pathogenesis of tuberculosis, yet the mechanisms that regulate these processes remain unclear. The Mycobacterium tuberculosis universal stress protein (USP) homolog, rv2623, is among