Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Patrick W. B. Derksen"'
Autor:
Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin Brisken, Patrick W. B. Derksen, Thijs Koorman, Daan Visser, Colinda L. G. J. Scheele, Daniela S. Thommen, Sigrid Hatse, Sarah-Maria Fendt, Evy Vanderheyden, Thomas Van Brussel, Rogier Schepers, Bram Boeckx, Diether Lambrechts, Giuseppe Marano, Elia Biganzoli, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, François Richard, Giuseppe Floris, Christine Desmedt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8
Externí odkaz:
https://doaj.org/article/64acb1b4e34a40a5a3f7576042fa573b
Autor:
Karen Van Baelen, Josephine Van Cauwenberge, Marion Maetens, Gabriela Beck, Ann Camden, Megan-Claire Chase, Valerie Fraser, Siobhan Freeney, Laurie Hutcheson, Julia K. Levine, Tone Lien, Rian Terveer, Claire Turner, Elzbieta Senkus, Rachel C. Jankowitz, Vincent Vandecaveye, Giuseppe Floris, Patrick Neven, Hans Wildiers, Elinor Sawyer, Anne Vincent-Salomon, Patrick W. B. Derksen, Christine Desmedt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract Invasive lobular breast cancer (ILC) differs from invasive breast cancer of no special type in many ways. Evidence on treatment efficacy for ILC is, however, lacking. We studied the degree of documentation and representation of ILC in phase
Externí odkaz:
https://doaj.org/article/df5baec4f9804827a424183db7190118
Autor:
George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V. Lee, Jos Jonkers, Valerie G. Brunton, Matthias Christgen, Clare Isacke, Patrick W. B. Derksen, Cathrin Brisken
Publikováno v:
Cancers, Vol 13, Iss 21, p 5396 (2021)
Invasive lobular carcinoma (ILC) accounts for up to 15% of all breast cancer (BC) cases and responds well to endocrine treatment when estrogen receptor α-positive (ER+) yet differs in many biological aspects from other ER+ BC subtypes. Up to 30% of
Externí odkaz:
https://doaj.org/article/e9a688d788384c04ad1a7eade81bf161
Autor:
Matthias Christgen, Gábor Cserni, Giuseppe Floris, Caterina Marchio, Lounes Djerroudi, Hans Kreipe, Patrick W. B. Derksen, Anne Vincent-Salomon
Publikováno v:
Cancers, Vol 13, Iss 15, p 3695 (2021)
Invasive lobular breast cancer (ILC) is the most common special histological type of breast cancer (BC). This review recapitulates developments in the histomorphologic assessment of ILC from its beginnings with the seminal work of Foote and Stewart,
Externí odkaz:
https://doaj.org/article/6c5f33a1918942bfb2d54d292b7bd11e
Autor:
Robert A. H. van de Ven, Milou Tenhagen, Wouter Meuleman, Jeske J. G. van Riel, Ron C. J. Schackmann, Patrick W. B. Derksen
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 4, Pp 373-384 (2015)
E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism dri
Externí odkaz:
https://doaj.org/article/b7bbaceb3afd41468abf0fd1753b7c88
Autor:
Patrick W. B. Derksen, Tanya M. Braumuller, Eline van der Burg, Marten Hornsveld, Elly Mesman, Jelle Wesseling, Paul Krimpenfort, Jos Jonkers
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 3, Pp 347-358 (2011)
SUMMARY Breast cancer is the most common malignancy in women of the Western world. Even though a large percentage of breast cancer patients show pathological complete remission after standard treatment regimes, approximately 30–40% are non-responsi
Externí odkaz:
https://doaj.org/article/8512f67f5a4f43cdbd394077728fdf09
Autor:
Robert A. H. van de Ven, Jolien S. de Groot, Danielle Park, Robert van Domselaar, Danielle de Jong, Karoly Szuhai, Elsken van der Wall, Oscar M. Rueda, H. Raza Ali, Carlos Caldas, Paul J. van Diest, Martin W. Hetzer, Erik Sahai, Patrick W. B. Derksen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7: Article number: 13874 (2016); Published 22 December 2016; Updated 6 September 2017 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included the National Institutes of Health
Externí odkaz:
https://doaj.org/article/146b7d7566bb4d11a0d25bc73322993b
Autor:
Lilian M. Sluimer, Esme Bullock, Max A. K. Rätze, Lotte Enserink, Celine Overbeeke, Marten Hornsveld, Valerie G. Brunton, Patrick W. B. Derksen, Sandra Tavares
Publikováno v:
Sluimer, L, Bullock, E, Ratze, M, Enserink, L, Overbeeke, C, Hornsveld, M, Brunton, V G, Derksen, P W B & Tavares, S 2023, ' SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells ', Journal of Cell Science, vol. 136, no. 3, jcs260243 . https://doi.org/10.1242/jcs.260243
High expression of the tyrosine kinase FER is an independent prognostic factor that correlates with poor survival in breast cancer patients. To investigate whether the kinase activity is essential for FER oncogenic properties, we developed an ATP ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a50db47529209457c83fae573feae8
https://www.pure.ed.ac.uk/ws/files/320926987/SKOR1_mediates_FER_kinase_dependent_invasive_growth_of_breast_cancer_cells_AAM.pdf
https://www.pure.ed.ac.uk/ws/files/320926987/SKOR1_mediates_FER_kinase_dependent_invasive_growth_of_breast_cancer_cells_AAM.pdf
Autor:
Lina M. Gallego-Paez, William J.S. Edwards, Yanyu Guo, Manasa Chanduri, Thijs Koorman, Chieh-Yu Lee, Nina Grexa, Patrick W. B. Derksen, Jie Yan, Martin A. Schwartz, Jan Mauer, Benjamin T. Goult
Talin 1 is the core mechanosensitive adapter protein linking integrins to the cytoskeleton. The TLN1 gene is comprised of 57 exons that encode the 2541 amino acid TLN1 protein. TLN1 was previously considered to be expressed as a single isoform. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5760f0a706abc619396f43b4c906889
https://doi.org/10.1101/2022.09.06.506802
https://doi.org/10.1101/2022.09.06.506802
Autor:
Max A. K. Rätze, Thijs Koorman, Thijmen Sijnesael, Blessing Bassey-Archibong, Robert van de Ven, Lotte Enserink, Daan Visser, Sridevi Jaksani, Ignacio Viciano, Elvira R. M. Bakker, François Richard, Andrew Tutt, Lynda O’Leary, Amanda Fitzpatrick, Pere Roca-Cusachs, Paul J. van Diest, Christine Desmedt, Juliet M. Daniel, Clare M. Isacke, Patrick W. B. Derksen
Publikováno v:
Oncogene. 41:3507-3509