Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Patrick W P Ng"'
Autor:
Peng Zhang, William J. Smith, Diana Caridha, Steven L. Zeichner, Peter K. Chiang, Richard A Leach, Mark J. Novak, Patrick W P Ng, Ludmila V. Asher
Publikováno v:
British Journal of Pharmacology. 137:245-252
2 Akt (PKB), a pivotal protein kinase which can block apoptosis and promotes cell survival, was identified to be chiefly down-regulated in a dose-dependent manner following CEES treatment. Functional analysis showed that the attendant Akt activity wa
Publikováno v:
Journal of Biological Chemistry. 273:15540-15545
Although the commonly activated death protease caspase-3 appears not to be essential for apoptosis during development except in the brain, it was not shown whether substrates known to be cleaved by caspase-3 are still proteolyzed in its absence. We h
Publikováno v:
BioEssays. 19:501-507
Interleukin 1 beta-converting enzyme (ICE)-like proteases (caspases) play an important role in programmed cell death (apoptosis), and elucidating the consequences of their proteolytic activity is central to our understanding of the molecular mechanis
Autor:
P. A. Walker, Shyh-Han Tan, David Murphy, L. E.-C. Leong, Sarah Waller, Alan G. Porter, Patrick W. P. Ng
Publikováno v:
Nature Biotechnology. 12:601-605
In the affinity purification of recombinant fusion proteins, the rate-limiting step is usually the efficient proteolytic cleavage and removal of the affinity tail and the protease from the purified recombinant protein. We have developed a rapid, conv
Autor:
Yi Chen, Patrick W P Ng, Yoichi Iwanaga, Jeffrey M. Trent, Steven L. Zeichner, Michael L. Bittner, Gerald C. Gooden, Paul S. Meltzer, Hidekatsu Iha, Yuan Jiang, Kuan-Teh Jeang
Publikováno v:
Oncogene. 20(33)
The Tax protein of human T-lymphotropic virus type 1 (HTLV-1), an oncoprotein that transactivates viral and cellular genes, plays a key role in HTLV-1 replication and pathogenesis. We used cDNA microarrays to examine Tax-mediated transcriptional chan
Publikováno v:
The Journal of biological chemistry. 274(15)
Caspase-10/a (Mch4) and caspase-10/b (FLICE2) are related death effector domain-containing cysteine aspartases presumed to be at or near the apex of apoptotic signaling pathways. We report the cloning and characterization of two novel proteins that a
Publikováno v:
Biochemical and biophysical research communications. 244(3)
We demonstrate that a 41 amino acid region (amino acids 379 to 419) in the cytoplasmic domain of tumor necrosis factor receptor 2 (TNFR2) is phosphorylated by unidentified kinase(s) both in vitro and in vivo. This domain (denoted x1c) corresponds alm
Autor:
Yee-Joo Tan, Seng Gee Lim, Phuay-Yee Goh, Y. H. Tan, Wanjin Hong, Patrick W. P. Ng, Siew-Pheng Lim
Publikováno v:
Virology. (2):250-269
Although CD81 has been shown to bind HCV E2 protein, its role as a receptor for HCV remains controversial. In this study, we constructed two CD81 chimeras by linking the cytoplasmic domains of recycling surface receptors, low-density lipoprotein rece
Autor:
Fullwood, Melissa J., Tan, Jack J. S., Ng, Patrick W. P., Chiu, Kuo Ping, Liu, Jun, Wei, Chia Lin, Ruan, Yijun
Publikováno v:
Nucleic Acids Research; 2008, Vol. 36 Issue 5, pe32-1, 1p