Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Patrick W, Oakes"'
Autor:
Yueyang Wang, Lee D Troughton, Fan Xu, Aritra Chatterjee, Chang Ding, Han Zhao, Laura P Cifuentes, Ryan B Wagner, Tianqi Wang, Shelly Tan, Jingjuan Chen, Linlin Li, David Umulis, Shihuan Kuang, Daniel M Suter, Chongli Yuan, Deva Chan, Fang Huang, Patrick W Oakes, Qing Deng
Publikováno v:
eLife, Vol 12 (2023)
Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophil-like cells via suppressing Rac activation. Here, we show that in mo
Externí odkaz:
https://doaj.org/article/80d2f4bf1af140f981ecc2ce933a1e23
Autor:
Elizabeth L Wagner, Jun-Sub Im, Stefano Sala, Maura I Nakahata, Terence E Imbery, Sihan Li, Daniel Chen, Katherine Nimchuk, Yael Noy, David W Archer, Wenhao Xu, George Hashisaki, Karen B Avraham, Patrick W Oakes, Jung-Bum Shin
Publikováno v:
eLife, Vol 12 (2023)
Prolonged exposure to loud noise has been shown to affect inner ear sensory hair cells in a variety of deleterious manners, including damaging the stereocilia core. The damaged sites can be visualized as ‘gaps’ in phalloidin staining of F-actin,
Externí odkaz:
https://doaj.org/article/c58afd57aa30460798c8d8ef6686916d
Autor:
Stefania Marcotti, Deandra Belo de Freitas, Lee D Troughton, Fiona N Kenny, Tanya J Shaw, Brian M Stramer, Patrick W Oakes
Publikováno v:
Frontiers in Computer Science, Vol 3 (2021)
Measuring the organization of the cellular cytoskeleton and the surrounding extracellular matrix (ECM) is currently of wide interest as changes in both local and global alignment can highlight alterations in cellular functions and material properties
Externí odkaz:
https://doaj.org/article/7c9b8a37505347c8ba8e87de3b3459cb
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
Autor:
Sarah R. Barger, Nicholas S. Reilly, Maria S. Shutova, Qingsen Li, Paolo Maiuri, John M. Heddleston, Mark S. Mooseker, Richard A. Flavell, Tatyana Svitkina, Patrick W. Oakes, Mira Krendel, Nils C. Gauthier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and a
Externí odkaz:
https://doaj.org/article/42adf260ea6c448fbdbf17cfb3eda9f6
Autor:
Yeonsun Hong, Brandon L. Walling, Hye-Ran Kim, William S. Serratelli, John R. Lozada, Cooper J. Sailer, Andrea M. Amitrano, Kihong Lim, Raj Kumar Mongre, Kyun-Do Kim, Tara Capece, Elena B. Lomakina, Nicholas S. Reilly, Kevin Vo, Scott A. Gerber, Tan-Chi Fan, Alice Lin-Tsing Yu, Patrick W. Oakes, Richard E. Waugh, Chang-Duk Jun, Patrick M. Reagan, Minsoo Kim
Publikováno v:
Nature Immunology. 24:1007-1019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2f431d602be072e876f67e3a4c234f7
https://doi.org/10.1038/s41590-023-01498-x
https://doi.org/10.1038/s41590-023-01498-x
Autor:
Yeonsun Hong, Hye-Ran Kim, Brandon L. Walling, John Lozada, Andrea M. Amitrano, Cooper J. Sailer, Kihong Lim, Raj Kumar Mongre, Kyun-Do Kim, Tara Capece, Elena B. Lomakina, Nicholas S. Reilly, Richard E. Waugh, Patrick M. Reagan, Minsoo Kim, Patrick W. Oakes, Chang-Duk Jun
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 57-57 (2022)
OBJECTIVES/GOALS: #NAME? METHODS/STUDY POPULATION: Cell culture & protein identification: human T cells were purified from healthy blood, then activated & cultured for 5d. CAR-T cells were collected from infusion bags of cancer patients undergoing CA
Externí odkaz:
https://doaj.org/article/f605ef69391e4c20b5889316e4a19c02
Autor:
Ninoshka R. J. Fernandes, Nicholas S. Reilly, Dillon C. Schrock, Denise C. Hocking, Patrick W. Oakes, Deborah J. Fowell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The extracellular matrix (ECM) is extensively remodeled during inflammation providing essential guidance cues for immune cell migration and signals for cell activation and survival. There is increasing interest in the therapeutic targeting of ECM to
Externí odkaz:
https://doaj.org/article/aedf7f6e1a07411bb0d8fa6edb4a0eec
Autor:
Daniel S. Seara, Vikrant Yadav, Ian Linsmeier, A. Pasha Tabatabai, Patrick W. Oakes, S. M. Ali Tabei, Shiladitya Banerjee, Michael P. Murrell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Myosin motors drive the actin cytoskeleton out-of-equilibrium, but the role of myosin-driven active stresses in the accumulation and dissipation of mechanical work is unclear. Here, the authors synthesize an actomyosin material and find that the rate
Externí odkaz:
https://doaj.org/article/e3e9d17bb7974171ac8d4a2c7e5a28d3
Autor:
Stefano Sala, Patrick W. Oakes
Publikováno v:
Current Biology. 33:R339-R341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1e9549a5b805a6afa4e8444d9d95c17
https://doi.org/10.1016/j.cub.2023.03.030
https://doi.org/10.1016/j.cub.2023.03.030
Autor:
Patrick W. Oakes, Elizabeth Wagner, Christoph A. Brand, Dimitri Probst, Marco Linke, Ulrich S. Schwarz, Michael Glotzer, Margaret L. Gardel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow
Externí odkaz:
https://doaj.org/article/447431f6514b4d158ce8bc4408d48bfd