Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Patrick T. Weiser"'
Autor:
Sihyung Yang, Reto Brun, Patrick T. Weiser, Richard R. Tidwell, Tanja Wenzler, Donald A. Patrick, Michael Zhuo Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2451-2465
2-(2-Benzamido)ethyl-4-phenylthiazole (1) was one of 1035 molecules (grouped into 115 distinct scaffolds) found to be inhibitory to Trypanosoma brucei, the pathogen causing human African trypanosomiasis, at concentrations below 3.6 μM and non-toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93545594ecb9bfebedcfa40cde4a2c3a
https://doi.org/10.1016/j.bmc.2016.04.006
https://doi.org/10.1016/j.bmc.2016.04.006
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:917-926
A series of unsymmetrically substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f5b02d331237cb56456a33b171b864
https://doi.org/10.1016/j.bmc.2013.10.051
https://doi.org/10.1016/j.bmc.2013.10.051
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6587-6590
A series of bipolar biphenyl compounds was synthesized as proteomimetic analogs of the LXXLL penta-peptide motif responsible for the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d7248ef52b5c2cea6124412d44e6ec
https://doi.org/10.1016/j.bmcl.2012.09.007
https://doi.org/10.1016/j.bmcl.2012.09.007
Autor:
Patrick T. Weiser, Anna B. Williams, Jillian R. Gunther, Robert N. Hanson, John A. Katzenellenbogen
Publikováno v:
Organic Letters. 11:5370-5373
A novel series of biphenyl proteomimetic compounds were designed as estrogen receptor-alpha (ER(alpha)) coactivator binding inhibitors. Synthesis was accomplished through a convergent approach, employing Suzuki coupling chemistry to ligate the indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ab3060b9ddbf86ad197430ab932c34
https://doi.org/10.1021/ol901999f
https://doi.org/10.1021/ol901999f
Autor:
Anna B. Williams, Patrick T. Weiser, Robert N. Hanson, Jillian R. Gunther, John A. Katzenellenbogen
Publikováno v:
Organic Letters; Dec2009, Vol. 11 Issue 23, p5370-5373, 4p