Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Patrick T. Ronaldson"'
Autor:
Jeffrey J. Lochhead, Erica I. Williams, Elizabeth S. Reddell, Emma Dorn, Patrick T. Ronaldson, Thomas P. Davis
Publikováno v:
Cells, Vol 12, Iss 4, p 645 (2023)
The neurovascular unit (NVU) is an anatomical group of cells that establishes the blood–brain barrier (BBB) and coordinates cerebral blood flow in association with neuronal function. In cerebral gray matter, cellular constituents of the NVU include
Externí odkaz:
https://doaj.org/article/1f52541bf61b4460a59d90affe72ff93
Autor:
Patrick T. Ronaldson, Thomas P. Davis
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1501 (2022)
Ischemic stroke is a primary origin of morbidity and mortality in the United States and around the world. Indeed, several research projects have attempted to discover new drugs or repurpose existing therapeutics to advance stroke pharmacotherapy. Man
Externí odkaz:
https://doaj.org/article/80304e7a51b44c029502dcd91112b087
Autor:
Junzhi Yang, Robert D. Betterton, Erica I. Williams, Joshua A. Stanton, Elizabeth S. Reddell, Chidinma E. Ogbonnaya, Emma Dorn, Thomas P. Davis, Jeffrey J. Lochhead, Patrick T. Ronaldson
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 949 (2022)
The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood–brain barrier (BBB) integrity are unknown. BBB changes by APAP can have profound consequences for brain delivery of co-admi
Externí odkaz:
https://doaj.org/article/3bb6e64239064ecc9e872abbd242f14f
Autor:
Kelsy L. Nilles, Erica I. Williams, Robert D. Betterton, Thomas P. Davis, Patrick T. Ronaldson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1898 (2022)
Globally, stroke is a leading cause of death and long-term disability. Over the past decades, several efforts have attempted to discover new drugs or repurpose existing therapeutics to promote post-stroke neurological recovery. Preclinical stroke stu
Externí odkaz:
https://doaj.org/article/e1c5b26816644d24ad839ec0b210494c
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding neurotoxic substances from the peripheral circulation. In contrast to the highly permeable vasculat
Externí odkaz:
https://doaj.org/article/b3d0b7b39f5449b090db69dcf541df67
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Background Targeting endogenous blood–brain barrier (BBB) transporters such as organic anion transporting polypeptide 1a4 (Oatp1a4) can facilitate drug delivery for treatment of neurological diseases. Advancement of Oatp targeting for opti
Externí odkaz:
https://doaj.org/article/e4df7f3dc4124510b9e3c022feef4c4e
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 154 (2020)
Ischemic stroke is the 5th leading cause of death in the United States. Despite significant improvements in reperfusion therapies, stroke patients still suffer from debilitating neurocognitive deficits. This indicates an essential need to develop nov
Externí odkaz:
https://doaj.org/article/3aad241a073642c2bc870f754ae5b3f6
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 192 (2018)
Opioids are highly effective analgesics that have a serious potential for adverse drug reactions and for development of addiction and tolerance. Since the use of opioids has escalated in recent years, it is increasingly important to understand biolog
Externí odkaz:
https://doaj.org/article/a76588a0c29a46bca9dffa8d99653f9d
Publikováno v:
Drug Transporters. :283-317
Autor:
Erica I Williams, Robert Betterton, Joshua A Stanton, Jeffrey J Lochhead, Thomas P Davis, Patrick T Ronaldson
Publikováno v:
Stroke. 54
Clinical development of new drugs for ischemic stroke has been challenging. In contrast, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (i.e., statins) are routinely administered to stroke patients because they improve neurological outcom