Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Patrick T. Flaherty"'
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 5, Pp 485-489 (2022)
The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal). The geometry of 1 is similar to its closely related analogues, chlorpropamide and tolbutamide
Externí odkaz:
https://doaj.org/article/275c0a7004734184b07f0e20ec05403e
Crystal structure of tert-butyl 4-[4-(4-fluorophenyl)-2-methylbut-3-yn-2-yl]piperazine-1-carboxylate
Autor:
Ashwini Gumireddy, Kevin DeBoyace, Alexander Rupprecht, Mohit Gupta, Saloni Patel, Patrick T. Flaherty, Peter L. D. Wildfong
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 4, Pp 360-365 (2021)
The title sterically congested piperazine derivative, C20H27FN2O2, was prepared using a modified Bruylants approach. A search of the Cambridge Structural Database identified 51 compounds possessing an N-tert-butyl piperazine substructure. Of these on
Externí odkaz:
https://doaj.org/article/f6a62e9d6de648d9ac40a4ad19ea1acb
Autor:
Akshita B. Bhatt, Thomas D. Wright, Van Barnes, Suravi Chakrabarty, Margarite D. Matossian, Erin Lexner, Deniz A. Ucar, Lucio Miele, Patrick T. Flaherty, Matthew E. Burow, Jane E. Cavanaugh
Publikováno v:
Translational Oncology, Vol 14, Iss 6, Pp 101046- (2021)
The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1). The EMT i
Externí odkaz:
https://doaj.org/article/741a151b8f16497b82667f09411e6156
Autor:
Khoa Nguyen, Minh N. Tran, Andrew Rivera, Thomas Cheng, Gabrielle O. Windsor, Abraham B. Chabot, Jane E. Cavanaugh, Bridgette M. Collins-Burow, Sean B. Lee, David H. Drewry, Patrick T. Flaherty, Matthew E. Burow
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 5, p 167 (2022)
The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we
Externí odkaz:
https://doaj.org/article/ae4f71ffb677486896b12ea1d2ecc0c0
Autor:
Van T. Hoang, Margarite D. Matossian, Deniz A. Ucar, Steven Elliott, Jacqueline La, Maryl K. Wright, Hope E. Burks, Aaron Perles, Fokhrul Hossain, Connor T. King, Valentino E. Browning, Jacob Bursavich, Fang Fang, Luis Del Valle, Akshita B. Bhatt, Jane E. Cavanaugh, Patrick T. Flaherty, Muralidharan Anbalagan, Brian G. Rowan, Melyssa R. Bratton, Kenneth P. Nephew, Lucio Miele, Bridgette M. Collins-Burow, Elizabeth C. Martin, Matthew E. Burow
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Conventional mitogen-activated protein kinase (MAPK) family members regulate diverse cellular processes involved in tumor initiation and progression, yet the role of ERK5 in cancer biology is not fully understood. Triple-negative breast cancer (TNBC)
Externí odkaz:
https://doaj.org/article/200b22265dbe421ba0329786d0153f68
Autor:
Akshita B. Bhatt, Mohit Gupta, Van T. Hoang, Suravi Chakrabarty, Thomas D. Wright, Steven Elliot, Ishveen K. Chopra, Darlene Monlish, Katie Anna, Matthew E. Burow, Jane E. Cavanaugh, Patrick T. Flaherty
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Epithelial to mesenchymal transition (EMT) is a cellular program that converts non-motile epithelial cells into invasive mesenchymal cells. EMT is implicated in cancer metastasis, chemo-resistance, cancer progression, and generation of cancer stem ce
Externí odkaz:
https://doaj.org/article/df10d63f800f4b54b1e02ff11056280c
Autor:
Akshita B. Bhatt, Saloni Patel, Margarite D. Matossian, Deniz A. Ucar, Lucio Miele, Matthew E. Burow, Patrick T. Flaherty, Jane E. Cavanaugh
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 183 (2021)
Extracellular signal-regulated kinase (ERK5) is an essential regulator of cancer progression, tumor relapse, and poor patient survival. Epithelial to mesenchymal transition (EMT) is a complex oncogenic process, which drives cell invasion, stemness, a
Externí odkaz:
https://doaj.org/article/8af4ad0094544d1bbf201b484f248a49
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 7, Pp o1336-o1337 (2008)
There are two independent molecules in the asymmetric unit of the title compound, C11H13N3O3. The interplanar angles for the two rings of the benzimidazole ring system is 2.21 (12)° in one molecule and 0.72 (12)° in the other. The nitro group is tw
Externí odkaz:
https://doaj.org/article/e71307cbdef34686b5fbcee1cb598c05
Autor:
Aaron Buechlein, Hope E. Burks, Van T. Hoang, Courtney K. Brock, Jane E. Cavanaugh, Jacqueline La, Steven Elliott, Patrick T. Flaherty, Matthew E. Burow, Margarite D. Matossian, Douglas B. Rusch, Kenneth P. Nephew, Bridgette M. Collins-Burow, Akshita B. Bhatt
Publikováno v:
Oncoscience
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited targeted therapeutic options. A defining feature of TNBC is the propensity to metastasize and acquire resistance to cytotoxic agents. Mitogen activated protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd24d23e6138d0cbd98efcb16596d0e1
https://doi.org/10.18632/oncoscience.535
https://doi.org/10.18632/oncoscience.535
Autor:
Van T. Hoang, Jacqueline La, Brian G. Rowan, Saloni Patel, Aaron Buechlein, Matthew E. Burow, Bridgette M. Collins-Burow, Margarite D. Matossian, Lucio Miele, Douglas B. Rusch, Akshita B. Bhatt, Murali Anbalagan, Douglas B. Chrisey, Thomas D. Wright, Jane E. Cavanaugh, Kristine Hoang, Steven Elliott, Patrick T. Flaherty, Kenneth P. Nephew, Deniz A. Ucar, Theresa B. Phamduy, Hope E. Burks
Publikováno v:
Journal of Cellular Biochemistry. 122:835-850
Triple-negative breast cancer (TNBC) presents a clinical challenge due to the aggressive nature of the disease and a lack of targeted therapies. Constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a2097f8e83f57573f0be34b12fd266
https://doi.org/10.1002/jcb.29916
https://doi.org/10.1002/jcb.29916