Výsledky vyhledávání - "Patrick T Rudak"

Akademický článek

Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin.

Autor: Fatemeh Khadir, Christopher R Shaler, Ahmad Oryan, Patrick T Rudak, Delfina M Mazzuca, Tahereh Taheri, Jimmy D Dikeakos, S M Mansour Haeryfar, Sima Rafati

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006701 (2018)

Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in t

Externí odkaz: https://doaj.org/article/d7617d3c1b8a423690c9ad2aa72beeec

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Akademický článek

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression.

Autor: Christopher R Shaler, Joshua Choi, Patrick T Rudak, Arash Memarnejadian, Peter A Szabo, Mauro E Tun-Abraham, Jamie Rossjohn, Alexandra J Corbett, James McCluskey, John K McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, S M Mansour Haeryfar

Publikováno v: PLoS Biology, Vol 15, Iss 6, p e2001930 (2017)

Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically

Externí odkaz: https://doaj.org/article/4b24ea4518434fc0a5371e496f1d85b0

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Longitudinal analysis of mucosa‐associated invariant T cells in sepsis reveals their early numerical decline with prognostic implications and a progressive loss of antimicrobial functions

Autor: Joshua Choi, Crystal L Schmerk, Tina S Mele, Patrick T Rudak, Christine M Wardell, Gansen Deng, Farzan R Pavri, Kyoungok Kim, Gediminas Cepinskas, Wenqing He, SM Mansour Haeryfar

Publikováno v: Immunology & Cell Biology. 101:249-261

Sepsis-elicited immunosuppression elevates the risk of secondary infections. We used a clinically relevant mouse model and serial peripheral blood samples from patients to assess the antimicrobial activities of mucosa-associated invariant T (MAIT) ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211364bd8dca1eafbddbea2b1d94ce76
https://doi.org/10.1111/imcb.12619

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In Vivo Cytotoxicity by α-GalCer-transactivated NK Cells

Autor: Patrick T, Rudak, S M Mansour, Haeryfar

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2388

Invariant natural killer T (iNKT) cells are innate-like, lipid-reactive T lymphocytes known for their potent immunomodulatory properties. In addition to expressing and utilizing cytolytic effector molecules of their own against certain target cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfe75ae6c15ce58274080fa51d5d7813
https://pubmed.ncbi.nlm.nih.gov/34524671

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Stress-elicited glucocorticoid receptor signaling upregulates TIGIT in innate-like invariant T lymphocytes

Autor: Wataru Inoue, S. M. Mansour Haeryfar, Kelly L. Summers, Dwayne N. Jackson, Amer M. Burhan, Joshua Choi, Patrick T. Rudak, Rakshith Gangireddy

Publikováno v: Brain, Behavior, and Immunity. 80:793-804

Stress is known to impede certain host defense mechanisms, including those governed by conventional T lymphocytes. However, whether innate-like T lymphocytes, such as invariant natural killer T (iNKT) and mucosa-associated invariant T (MAIT) cells, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8c3483bd833fdd83c129db4783604e
https://doi.org/10.1016/j.bbi.2019.05.027

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Chronic stress physically spares but functionally impairs innate-like invariant T cells

Autor: K. L. Summers, Ken Leslie, Anton I. Skaro, S. M. Mansour Haeryfar, Wataru Inoue, Vijay K. Kuchroo, Paula J. Foster, Joshua Choi, Olivier Lantz, Patrick T. Rudak, Vivian C. McAlister, Katie M. Parkins, Dwayne N. Jackson

Publikováno v: Cell Reports, Vol 35, Iss 2, Pp 108979-(2021)
Cell reports

SUMMARY The deleterious effects of psychological stress on mainstream T lymphocytes are well documented. However, how stress impacts innate-like T cells is unclear. We report that long-term stress surprisingly abrogates both T helper 1 (TH1)- and TH2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb46886ed71fb2f27c1ac9e1b1a1143
http://www.sciencedirect.com/science/article/pii/S221112472100293X

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MAIT cells accumulate in ovarian cancer-elicited ascites where they retain their capacity to respond to MR1 ligands and cytokine cues

Autor: Tony, Yao, Patrick T, Rudak, Céline M, Laumont, Alex R, Michaud, Rasheduzzaman, Rashu, Natasha N, Knier, Paula J, Foster, Hamish E G, McWilliam, Jose A, Villadangos, Brad H, Nelson, Gabriel E, DiMattia, Trevor G, Shepherd, S M Mansour, Haeryfar

Publikováno v: Cancer immunology, immunotherapy : CII. 71(5)

The low mutational burden of epithelial ovarian cancer (EOC) is an impediment to immunotherapies that rely on conventional MHC-restricted, neoantigen-reactive T lymphocytes. Mucosa-associated invariant T (MAIT) cells are MR1-restricted T cells with r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::250c1addcfb8a8b59f8a393bb4c8972e
https://pubmed.ncbi.nlm.nih.gov/34854949

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In Vivo Cytotoxicity by α-GalCer-transactivated NK Cells

Autor: S. M. Mansour Haeryfar, Patrick T. Rudak

Publikováno v: Methods in Molecular Biology ISBN: 9781071617748

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12bf86c057114fa3e4f7cd3d8138eb3b
https://doi.org/10.1007/978-1-0716-1775-5_15

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Physical restraint mouse models to assess immune responses under stress with or without habituation

Autor: S. M. Mansour Haeryfar, Patrick T. Rudak, Jian Xiang Ding, Wataru Inoue

Publikováno v: STAR Protocols, Vol 2, Iss 4, Pp 100838-(2021)

Summary Physical confinement, or restraint, is a psychological stressor used in rodent studies. A single restraint episode elevates blood corticosterone levels, a hallmark of stress responses. Repeated restraint results in habituation (or desensitiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4897b92318472427057ab371a94ad2bf
https://doi.org/10.1016/j.xpro.2021.100838

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