Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Patrick T F Kennedy"'
Autor:
Upkar S Gill, Patrick T F Kennedy, Andrew Hall, Rageshri Dhairyawan, Alberto Quaglia, James M Harris, Colin Nixon, Fadi Issa, Amy Cross, Edward Arbe-Barnes, Jane A McKeating, Dimitra Peppa
Publikováno v:
eGastroenterology, Vol 2, Iss 3 (2024)
Background and aims The intrahepatic processes associated with chronic hepatitis B (CHB), especially in the context of hepatitis delta virus (HDV) and HIV co-infection, require a better understanding. Spatial transcriptomics can provide new insights
Externí odkaz:
https://doaj.org/article/fc1ee0e355574540accc5e4589a7d9e0
Autor:
Upkar S Gill, Dimitra Peppa, Lorenzo Micco, Harsimran D Singh, Ivana Carey, Graham R Foster, Mala K Maini, Patrick T F Kennedy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005788 (2016)
NK cells are important antiviral effectors, highly enriched in the liver, with the potential to regulate immunopathogenesis in persistent viral infections. Here we examined whether changes in the NK pool are induced when patients with eAg-positive CH
Externí odkaz:
https://doaj.org/article/9aebe2de77234f2391741401188b7e4c
Autor:
Dimitra Peppa, Lorenzo Micco, Alia Javaid, Patrick T F Kennedy, Anna Schurich, Claire Dunn, Celeste Pallant, Gidon Ellis, Pooja Khanna, Geoffrey Dusheiko, Richard J Gilson, Mala K Maini
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001227 (2010)
NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death ligand TRAIL in patients with chronic hepatitis B virus infection (CHB), allowing them to kill
Externí odkaz:
https://doaj.org/article/ffd688712266402aa9a1b4de8190e233
Autor:
Romina Salpini, Stefano D’Anna, Livia Benedetti, Lorenzo Piermatteo, Upkar Gill, Valentina Svicher, Patrick T. F. Kennedy
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Chronic infection with Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality worldwide. HBV-DNA integration into the human genome is recognized as a frequent event occurring during the early phases of HBV infection and cha
Externí odkaz:
https://doaj.org/article/92bb7c3f0a074acfb9c5fa08946552cc
Autor:
Young-Suk Lim, W. Ray Kim, Douglas Dieterich, Jia-Horng Kao, John F. Flaherty, Leland J. Yee, Lewis R. Roberts, Homie Razavi, Patrick T. F. Kennedy
Publikováno v:
Viruses, Vol 15, Iss 4, p 997 (2023)
Chronic hepatitis B (CHB) is the most common cause of hepatocellular carcinoma (HCC) worldwide. Antiviral treatment reduces the risk of HCC and mortality; nonetheless, globally in 2019, only 2.2% of CHB patients received treatment. Current internatio
Externí odkaz:
https://doaj.org/article/b0f820d04b534e6eae9f1231aec2919b
Publikováno v:
Viruses, Vol 14, Iss 5, p 900 (2022)
Chronic hepatitis B (CHB) is associated with significant morbidity and mortality, due to the adverse sequelae of cirrhosis and hepatocellular carcinoma (HCC). To date, antiviral therapy has been reserved for patients with ostensibly active liver dise
Externí odkaz:
https://doaj.org/article/c501602f7d17494c8e76d0a526786b72
Autor:
Laura J. Pallett, Leo Swadling, Mariana Diniz, Alexander A. Maini, Marius Schwabenland, Adrià Dalmau Gasull, Jessica Davies, Stephanie Kucykowicz, Jessica K. Skelton, Niclas Thomas, Nathalie M. Schmidt, Oliver E. Amin, Upkar S. Gill, Kerstin A. Stegmann, Alice R. Burton, Emily Stephenson, Gary Reynolds, Matt Whelan, Jenifer Sanchez, Roel de Maeyer, Clare Thakker, Kornelija Suveizdyte, Imran Uddin, Ana M. Ortega-Prieto, Charlotte Grant, Farid Froghi, Giuseppe Fusai, Sabela Lens, Sofia Pérez-del-Pulgar, Walid Al-Akkad, Giuseppe Mazza, Mahdad Noursadeghi, Arne Akbar, Patrick T. F. Kennedy, Brian R. Davidson, Marco Prinz, Benjamin M. Chain, Muzlifah Haniffa, Derek W. Gilroy, Marcus Dorner, Bertram Bengsch, Anna Schurich, Mala K. Maini
Publikováno v:
Nature. 614:334-342
Publikováno v:
Journal of Viral Hepatitis. 30:12-21
Hepatitis D virus (HDV) causes one of the most severe forms of hepatitis in people with chronic hepatitis B (CHB) infection. Timely and accurate assessment of hepatitis delta virus (HDV) and disease stratification is mandatory for thorough pre-therap
Autor:
Lorenzo Piermatteo, Mohammad Alkhatib, Stefano D’Anna, Vincenzo Malagnino, Ada Bertoli, Eleonora Andreassi, Elisa Basile, Alessandra Iuvara, Maria De Cristofaro, Giuseppina Cappiello, Carlotta Cerva, Carmine Minichini, Mariantonietta Pisaturo, Mario Starace, Nicola Coppola, Carla Fontana, Sandro Grelli, Francesca Ceccherini-Silberstein, Massimo Andreoni, Upkar S. Gill, Patrick T. F. Kennedy, Loredana Sarmati, Romina Salpini, Valentina Svicher
Publikováno v:
Biomedicines, Vol 9, Iss 10, p 1352 (2021)
HBeAg is a marker of HBV-activity, and HBeAg-loss predicts a favorable clinical outcome. Here, we characterize HBeAg-levels across different phases of HBV infection, their correlation with virological/biochemical markers and the virological response
Externí odkaz:
https://doaj.org/article/fc62f2e8dcdf48d9a45d80e5744a1f28
Autor:
Arzoo M Patel, Zania Stamataki, Patrick T F Kennedy, Benjamin G. Wiggins, Xiaoyan Li, Yuxin S. Liu, Scott P Davies, Laura J. Pallett, Upkar S. Gill, Amir Gander, Gideon M. Hirschfield, Brian R. Davidson, Konstantinos Aliazis, Tu Vinh Luong, Yuehua Huang, Oliver E. Amin, Mala K. Maini, Stephanie Kucykowicz, Gary M. Reynolds
Publikováno v:
Gut. 71:1399-1411
ObjectiveTissue-resident memory T cells (TRM) are vital immune sentinels that provide protective immunity. While hepatic CD8+ TRM have been well described, little is known about the location, phenotype and function of CD4+ TRM.DesignWe used multipara