Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Patrick T, McGann"'
Autor:
Thomas A. Russo, Ulrike Carlino-MacDonald, Zachary J. Drayer, Connor J. Davies, Cassandra L. Alvarado, Alan Hutson, Ting L. Luo, Melissa J. Martin, Patrick T. McGann, Francois Lebreton
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105302- (2024)
Summary: Background: Quantitating the contribution of phenotype-responsible elements in hypervirulent Klebsiella pneumoniae is needed. Methods: Isogenic mutants of four hypervirulent clinical isolates that produced K1 (ST23), K2 (ST86), K20 (ST1544),
Externí odkaz:
https://doaj.org/article/c0046d7aaaad4f5bad88645c49551b50
Autor:
Thomas A. Russo, Cassandra L. Alvarado, Connor J. Davies, Zachary J. Drayer, Ulrike Carlino-MacDonald, Alan Hutson, Ting L. Luo, Melissa J. Martin, Brendan W. Corey, Kara A. Moser, J. Kamile Rasheed, Alison L. Halpin, Patrick T. McGann, Francois Lebreton
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Distinguishing hypervirulent (hvKp) from classical Klebsiella pneumoniae (cKp) strains is important for clinical care, surveillance, and research. Some combinations of iucA, iroB, peg-344, rmpA, and rmpA2 are most commonly used, but it is un
Externí odkaz:
https://doaj.org/article/9cb901119ec540dfbd9d0dc62e7d8198
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Enhanced levels of resistance to antibiotics arising from amplification of an antibiotic resistance gene that impact therapeutic options are increasingly observed. Amplification can also disclose novel phenotypes leading to treatment failure
Externí odkaz:
https://doaj.org/article/a9d660f9818046d799659642b28686ab
Autor:
Leon Tshilolo, Baba Inusa, Kwaku Ohene-Frempong, Jonathan Spector, Julie Makani, Siana Nkya, Natalie Henrich, Natasha M Archer, Venee N Tubman, Patrick T McGann, Emmanuela Eusebio Ambrose
Publikováno v:
BMJ Open, Vol 12, Iss 3 (2022)
Objectives Given the fundamental role of newborn bloodspot screening (NBS) to enable prompt diagnosis and optimal clinical management of individuals with sickle cell disease (SCD), we sought to systematically assess enablers and barriers to implement
Externí odkaz:
https://doaj.org/article/b2f0d8b1d15f4f8fb4f2c5133533fcdc
Autor:
Emily R. Meier, Susan E. Creary, Matthew M. Heeney, Min Dong, Abena O. Appiah-Kubi, Stephen C. Nelson, Omar Niss, Connie Piccone, Maa-Ohui Quarmyne, Charles T. Quinn, Kay L. Saving, John P. Scott, Ravi Talati, Teresa S. Latham, Amanda Pfeiffer, Lisa M. Shook, Alexander A. Vinks, Adam Lane, Patrick T. McGann
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Sickle cell disease (SCD) is a severe and devastating hematological disorder that affects over 100,000 persons in the USA and millions worldwide. Hydroxyurea is the primary disease-modifying therapy for the SCD, with proven benefi
Externí odkaz:
https://doaj.org/article/f4848c1e5cb84d1ca9d6331a034404f0
Autor:
Marina S. Perez-Plazola, Erika A. Tyburski, Luke R. Smart, Thad A. Howard, Amanda Pfeiffer, Russell E. Ware, Wilbur A. Lam, Patrick T. McGann
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background Severe anemia is common and frequently fatal for hospitalized patients in limited-resource settings. Lack of access to low-cost, accurate, and rapid diagnosis of anemia impedes the delivery of life-saving care and appropriate use
Externí odkaz:
https://doaj.org/article/0a5773500b6642c381c0a66bc48e41f1
Autor:
Ann T. Farrell, Julie Panepinto, Ankit A. Desai, Adetola A. Kassim, Jeffrey Lebensburger, Mark C. Walters, Daniel E. Bauer, Rae M. Blaylark, Donna M. DiMichele, Mark T. Gladwin, Nancy S. Green, Kathryn Hassell, Gregory J. Kato, Elizabeth S. Klings, Donald B. Kohn, Lakshmanan Krishnamurti, Jane Little, Julie Makani, Punam Malik, Patrick T. McGann, Caterina Minniti, Claudia R. Morris, Isaac Odame, Patricia Ann Oneal, Rosanna Setse, Poornima Sharma, Shalini Shenoy
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 4002-4020 (2019)
Abstract: To address the global burden of sickle cell disease and the need for novel therapies, the American Society of Hematology partnered with the US Food and Drug Administration to engage the work of 7 panels of clinicians, investigators, and pat
Externí odkaz:
https://doaj.org/article/06caa969e3bd4e5b84bcc4cdd2e86f79
Autor:
Andrey A. Filippov, Wanwen Su, Kirill V. Sergueev, Richard T. Kevorkian, Erik C. Snesrud, Apichai Srijan, Yunxiu He, Derrick E. Fouts, Woradee Lurchachaiwong, Patrick T. McGann, Damon W. Ellison, Brett E. Swierczewski, Mikeljon P. Nikolich
Publikováno v:
Antibiotics, Vol 11, Iss 11, p 1659 (2022)
Shigellosis is a leading global cause of diarrheal disease and travelers’ diarrhea now being complicated by the dissemination of antibiotic resistance, necessitating the development of alternative antibacterials such as therapeutic bacteriophages (
Externí odkaz:
https://doaj.org/article/271f48e9383240e28dc902883835d77e
Autor:
Honghui Wang, Yong Chen, Jeffrey R. Strich, Steven K. Drake, Jung-Ho Youn, Avi Z. Rosenberg, Marjan Gucek, Patrick T. McGann, Anthony F. Suffredini, John P. Dekker
Publikováno v:
Clinical Proteomics, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Colistin (polymyxin E) and polymixin B are important bactericidal antibiotics used in the treatment of serious infections caused by multi-drug resistant Gram-negative organisms. Transferrable plasmid-mediated colistin resistance,
Externí odkaz:
https://doaj.org/article/4331f9a41a214da3b0c2055a8a84357e
Autor:
Daniel Dexter, Patrick T. McGann
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 43:430-441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18c1e9738fa25f1cdbf1649b51ea090
https://doi.org/10.1002/phar.2792
https://doi.org/10.1002/phar.2792