Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Patrick Stoy"'
Autor:
Lisa M. Shewchuk, Rachel D. Totoritis, Tina A. Desai, Liping Wang, Mui Cheung, Jaclyn R. Patterson, Dennis A. Holt, Patrick Stoy, Harvey E. Fries, Lara S. Kallander, Gatto Gregory J, Alan P. Graves
Publikováno v:
Journal of Medicinal Chemistry. 64:15651-15670
A series of diarylurea inhibitors of the cardiac-specific kinase TNNI3K were developed to elucidate the biological function of TNNI3K and evaluate TNNI3K as a therapeutic target for the treatment of cardiovascular diseases. Utilizing a structure-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa474202f9b9f70b991b8dc722edbff
https://doi.org/10.1021/acs.jmedchem.1c00700
https://doi.org/10.1021/acs.jmedchem.1c00700
Autor:
Eidam Hilary Schenck, Theresa J. Roethke, Linda S. Barton, Fox Ryan Michael, Steve Zhao, Kevin S. Thorneloe, David J. Behm, Guosen Ye, Patrick Stoy, Mui Cheung, Tram H. Hoang, Dennis A. Holt, Krista B. Goodman, Brian G. Lawhorn, Marlys Hammond, Mark A. Hilfiker, Carl Brooks, Jaclyn R. Patterson
Publikováno v:
ACS Med Chem Lett
[Image: see text] GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel for the treatment of pulmonary edema associated with congestive heart failure. We discuss the lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9fa0019b6d3c13ef62367e4364c46c
https://doi.org/10.1021/acsmedchemlett.9b00274
https://doi.org/10.1021/acsmedchemlett.9b00274
Autor:
Patrick Stoy, Joerg Holenz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:517-524
Lead Generation represents a critical drug discovery phase where chemical starting points and their respective mechanism of action, quality, and potential liabilities are largely predefined. Recent advances such as DNA-encoded libraries or fragment-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e701d8472362f1295893f3e177578b6
https://doi.org/10.1016/j.bmcl.2018.12.001
https://doi.org/10.1016/j.bmcl.2018.12.001
Publikováno v:
Chemical reviews. 121(3)
Chlorinated solvents were once, and in many places are still, ubiquitous in chemistry laboratories. This review explores the properties that led to such widespread use, why there is now an increasing drive to minimize usage, and what alternatives are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63b817781eb04d7b6f8ebe0a80f2087
https://pubmed.ncbi.nlm.nih.gov/33351588
https://pubmed.ncbi.nlm.nih.gov/33351588
Autor:
Guosen Ye, Arthur Shu, Dennis A. Holt, Patrick Stoy, Carla A. Donatelli, Larry J. Jolivette, Ralph A. Rivero, Mark Youngman, Lamont Roscoe Terrell, Jaclyn R. Patterson, Brian G. Lawhorn, Theresa J. Roethke
Publikováno v:
Journal of medicinal chemistry. 63(23)
Investigation of TRPV4 as a potential target for the treatment of pulmonary edema associated with heart failure generated a novel series of acyclic amine inhibitors displaying exceptional potency and PK properties. The series arose through a scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0c927080fe1de87583cbdaf88c1101
https://pubmed.ncbi.nlm.nih.gov/33201708
https://pubmed.ncbi.nlm.nih.gov/33201708
Autor:
Kevin S. Thorneloe, Theresa J. Roethke, Krista B. Goodman, Jaclyn R. Patterson, Dennis L. Sprecher, Navin Goyal, Melissa H. Costell, David J. Behm, Christian H. James, Patrick Stoy, Xiaoping Xu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 376(3)
Transient receptor potential vanilloid 4 (TRPV4) channels expressed on pulmonary endothelial cells are activated by elevated pulmonary vascular pressure, resulting in endothelial shape change, pulmonary barrier disruption, and edema. As such, TRPV4 b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50663aab15250e2bcb3f8a1a370e399c
https://pubmed.ncbi.nlm.nih.gov/33376150
https://pubmed.ncbi.nlm.nih.gov/33376150
Autor:
Arthur Shu, Carla A. Donatelli, Sanchez Robert, Melissa H. Costell, Carl Brooks, Yanan He, Jeff J. McAtee, David J. Behm, Guosen Ye, Dennis A. Holt, Theresa J. Roethke, Brian G. Lawhorn, Grazyna Graczyk-Millbrandt, Lamont Roscoe Terrell, Edward J. Brnardic, Patrick Stoy, Linda S. Barton, Karl F. Erhard
Publikováno v:
Journal of medicinal chemistry. 61(21)
A novel series of pyrrolidine sulfonamide transient receptor potential vanilloid-4 (TRPV4) antagonists was developed by modification of a previously reported TRPV4 inhibitor (1). Several core-structure modifications were identified that improved TRPV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188dc34bb0a3617511cb674a19186ee6
https://pubmed.ncbi.nlm.nih.gov/30335378
https://pubmed.ncbi.nlm.nih.gov/30335378
Autor:
Septimiu Dan Murgu, Sean Patrick Stoy
Publikováno v:
Interventions in Pulmonary Medicine ISBN: 9783319580357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6690e0d8171fd065bb0670da2e3fd1eb
https://doi.org/10.1007/978-3-319-58036-4_13
https://doi.org/10.1007/978-3-319-58036-4_13
Publikováno v:
The Journal of Organic Chemistry. 69:1919-1939
Nonstabilized azomethine ylides (i.e. those bearing only hydrogens or alkyl groups) can be generated from (2-azaallyl)stannanes and (2-azaallyl)silanes through an intramolecular N-alkylation/demetalation cascade. The resulting ylides undergo [3+2] cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d904c14104a108f02402a26265b6e9d
https://doi.org/10.1021/jo030334h
https://doi.org/10.1021/jo030334h
Publikováno v:
Synthetic Communications. 34:3481-3489
An efficient synthesis of 9,10‐dihydro‐9,10‐(methaniminomethano)anthracene and several N‐protected derivatives is described via the double reductive amination of cis‐9,10‐dihydro‐9,10‐dicarboxaldehyde.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05789d49ec34320a28af19c155a7a3ba
https://doi.org/10.1081/scc-200030972
https://doi.org/10.1081/scc-200030972