Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Patrick Sorn"'
Autor:
Thomas Bukur, Pablo Riesgo-Ferreiro, Patrick Sorn, Ranganath Gudimella, Johannes Hausmann, Thomas Rösler, Martin Löwer, Barbara Schrörs, Ugur Sahin
Publikováno v:
Viruses, Vol 15, Iss 6, p 1391 (2023)
Background: The outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulted in the global COVID-19 pandemic. The urgency for an effective SARS-CoV-2 vaccine has led to the development of the first series of vaccines at unpre
Externí odkaz:
https://doaj.org/article/a052a53a25a84b7aaa9a0b2eac1e543d
Autor:
Bernd Schöpf, Hansi Weissensteiner, Georg Schäfer, Federica Fazzini, Pornpimol Charoentong, Andreas Naschberger, Bernhard Rupp, Liane Fendt, Valesca Bukur, Irina Giese, Patrick Sorn, Ana Carolina Sant’Anna-Silva, Javier Iglesias-Gonzalez, Ugur Sahin, Florian Kronenberg, Erich Gnaiger, Helmut Klocker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels
Externí odkaz:
https://doaj.org/article/5f0501c636064d6cb8123ea16319c072
Autor:
Barbara Schrörs, Pablo Riesgo-Ferreiro, Patrick Sorn, Ranganath Gudimella, Thomas Bukur, Thomas Rösler, Martin Löwer, Ugur Sahin
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0249254 (2021)
Due to the widespread of the COVID-19 pandemic, the SARS-CoV-2 genome is evolving in diverse human populations. Several studies already reported different strains and an increase in the mutation rate. Particularly, mutations in SARS-CoV-2 spike-glyco
Externí odkaz:
https://doaj.org/article/37f08c2151554ad79d9100c6ddc74c9a
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background The presentation of HLA peptide complexes to T cells is a highly regulated and tissue specific process involving multiple transcriptionally controlled cellular components. The extensive polymorphism of HLA genes and the complex co
Externí odkaz:
https://doaj.org/article/0e31c173a1ef4fa595c68594e1cb9c3d
Autor:
Sahin, Thomas Bukur, Pablo Riesgo-Ferreiro, Patrick Sorn, Ranganath Gudimella, Johannes Hausmann, Thomas Rösler, Martin Löwer, Barbara Schrörs, Ugur
Publikováno v:
Viruses; Volume 15; Issue 6; Pages: 1391
Background: The outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulted in the global COVID-19 pandemic. The urgency for an effective SARS-CoV-2 vaccine has led to the development of the first series of vaccines at unpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::9e12f0051d15b39ff3a45c97fcf3298a
Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens
Autor:
David Weber, Jonas Ibn-Salem, Patrick Sorn, Martin Suchan, Christoph Holtsträter, Urs Lahrmann, Isabel Vogler, Kathrin Schmoldt, Franziska Lang, Barbara Schrörs, Martin Löwer, Ugur Sahin
Publikováno v:
Nature Biotechnology
Nat Biotechnol
Nat Biotechnol
Cancer associated gene fusions (GF) are a potential source for highly immunogenic neo-antigens, but the lack of computational tools for accurate, sensitive identification of personal GFs has limited their targeting in personalized cancer immunotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f451bc3a74374e4f8f9989754534e6f6
https://doi.org/10.1038/s41587-022-01247-9
https://doi.org/10.1038/s41587-022-01247-9
Autor:
Pablo Riesgo-Ferreiro, Ranganath Gudimella, Thomas Bukur, Patrick Sorn, Thomas Rösler, Barbara Schrörs, Martin Löwer
IntroductionThe B.1.1.529 (Omicron) SARS-CoV-2 variant has raised global concerns due to its high number of mutations and its rapid spread. It is of major importance to understand the impact of this variant on the acquired and induced immunity. Sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71269e0d23222ac5586f5016a83e93d0
https://doi.org/10.1101/2022.01.31.478157
https://doi.org/10.1101/2022.01.31.478157
Publikováno v:
Bioinformatics. 36:373-379
Motivation Gene fusions are an important class of transcriptional variants that can influence cancer development and can be predicted from RNA sequencing (RNA-seq) data by multiple existing tools. However, the real-world performance of these tools is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2bb9cd90740ed9b6a27d841d280756
https://doi.org/10.1093/bioinformatics/btz613
https://doi.org/10.1093/bioinformatics/btz613
Autor:
Jochen Utikal, Isabel Vogler, Özlem Türeci, Tana Omokoko, Christoph Höller, Matthias Miller, Björn-Philipp Kloke, Inga Ortseifer, Sebastian Attig, Goran Martic, Barbara Schrörs, Andrea Breitkreuz, Christoph Huber, Janina Buck, Valesca Bukur, Alexander Hohberger, Andreas Kuhn, Anna Paruzynski, Martina Zillgen, Meike Witt, Sandra Heesch, Jan Diekmann, Stefanie Bolte, Evelyna Derhovanessian, Christoffer Gebhardt, Ulrich Luxemburger, Alexandra-Kemmer Brück, Petra Simon, Arbel D. Tadmor, Patrick Sorn, Stephan Grabbe, Felicitas Müller, Sebastian Kreiter, Martin Suchan, David Langer, Mathias Vormehr, Christian Albrecht, Mustafa Diken, Eva Godehardt, Claudia Tolliver, Romina Nemecek, Martin Löwer, Katharina H Schreeb, Barbara Kasemann, Richard Rae, Carmen Loquai, Olga Waksmann, Andrée Rothermel, Ugur Sahin, Janko Ciesla
Publikováno v:
Nature. 547:222-226
T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of individualized mutanome vaccines and implemented an RNA-based poly-neo-epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb4ccb9b5ff2d67566919b8a33f73443
https://doi.org/10.1038/nature23003
https://doi.org/10.1038/nature23003
Autor:
Patrick Sorn, Valesca Boisguerin, John C. Castle, Jasmin Rößler, Ugur Sahin, Jos de Graaf, Jelle Scholtalbers
Publikováno v:
Bioinformatics (Oxford, England). 29(9)
Summary: We have developed a laboratory information management system (LIMS) for a next-generation sequencing (NGS) laboratory within the existing Galaxy platform. The system provides lab technicians standard and customizable sample information forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecab7bdcbac09c0dc035c27e91df991
https://pubmed.ncbi.nlm.nih.gov/23479349
https://pubmed.ncbi.nlm.nih.gov/23479349